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Trichosanthes kirilowii (Gua Lou): Cure for HIV, Herpes Simplex, Hepatitis B, Cancer, Diabetes, COVID, and More...

Posted By Jennifer Shipp | Oct 21, 2020

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Trichosanthes kirilowii / Gua Lou is one of the most valuable herbal treatments in Traditional Chinese Medicine for a reason.

Trichosanthes kirilowii: Herbal Remedy for Herpes, HIV, Hepatitis B, Cancer, Diabetes, COVID, and More...

A person who reads our research about herpes, HIV, diabetes, and cancer (among other things) in a cover-to-cover way might begin to notice patterns in the data. Herbs, for example, tend to have a lot to teach us in terms of how to cure disease. Trichosanthes kirilowii is no exception to this rule.

Trichosanthes kirilowii is a flowering plant that grows in China. It’s also known as “Chinese cucumber” or “Chinese snakegourd”. It is used by practitioners of Traditional Chinese Medicine to cure some of the most serious diseases of our time:

  • HIV
  • Herpes
  • Hepatitis
  • Cancer
  • COVID
  • Diabetes

But how is this possible? How can one herb do so many different things? As a knee-jerk reflex, most of us naturally assume that a medicine should adhere to the rule “one pill for one disease”. This is, after all, the propaganda that we’ve all been fed by Big Pharma. Whether you know it or not, you’ve been indoctrinated into this “ideal”. And whenever you go to a doctor of conventional medicine, you hope that he or she will give you a pill that was created especially for your disease. It’s a very rare thing these days for doctors to have a pill like that for any disease, even for very basic illnesses like a sinus infection or the common cold, but still, this is what motivates patients to go to the doctor.

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Nature isn’t quite so neat and tidy as the “one pill for one disease” model that we’ve all been taught. This is definitely a blessing because, while a sinus infection may seem to be an isolated event that’s happening in a fairly small area of your body, most of the time, health issues are a sign that there’s a weakness in multiple areas of the body. Sinus infections, for example, tend to originate in the gut. But, let’s not lose sight of the original discussion about herpes, HIV, cancer, hepatitis, and diabetes.

Herbs especially are not made to fit just one disease. Indeed, if we take a step back from the indoctrination of Big Pharma for just a moment and imagine choosing just one medicinal plant in the world that we know about and that we’ve worked with before. It might be a lemon (with honey) for a sore throat, for example. We all use plants medicinally, but we don’t always think about it consciously. But if we go back through history to hear the story of how humans have used said plant for centuries – we end up with more than just information about the plant itself. We actually end up with a profile of how certain diseases work and how to cure them.

That lemon, for example, contains vitamin C that acts to heal inflamed and damaged tissues and that also, in high doses, can kill pathogens via the production of reactive oxygen species. Indeed, the citric acid in lemon juice is a powerful cure for flesh-eating bacteria disease / gangrene, a fact that’s practically unknown to all but a few people in the world. Nonetheless, citric acid works better to cure gangrene than all of the expensive antibiotics available for treatment. The magic of lemon juice and the chemistry of this medicine changes depending on whether you ingest it orally or administer it to an area of the body that’s exposed to oxygen. In any case, lemons have something to teach us about healing damaged and infected tissues. And if we pay attention to it, it isn’t so hard to believe that the same plant that treats a sore, red, and infected throat might also work to treat a sore, red, and infected wound.

Click here to read more about how to cure gangrene using citric acid.

Trichosanthes kirilowii is a great example of what I’m talking about, too, in regard to herbs and their ability to teach us how diseases work in the body. If I imagine that T. kirilowii is not a plant, but rather a person – and not just any person, but a doctor – I can see that she’s definitely not a general practitioner. She has a specialty. She doesn’t try to treat gangrene, for example, or sore throats. T. kirilowii is more interested in treating diseases that are really common today and that often co-exist.

And then, if I imagine that T. kirilowii works with a specific type of patient who fits a particular profile – kind of like having a specialty in a field of conventional medicine – I begin to see what this plant has to say about curing disease. T. kirilowii knows that liver problems, herpes, HIV, cancer, and diabetes all have the same root cause in her patients. She’s able to treat all of these diseases because they’re all caused by the same basic problem. So she digs in to help people root out the core of the disease at the level of the liver specifically. 

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She knows that the liver can play host to colonies of pathogens like herpes, HIV, and COVID. She also knows that the liver is often the organ that gets toxic last among the organs of detoxification (which includes the kidneys, intestines, skin, and liver). If the other organs of the body have become too toxic to be able to remove more toxins than what the body is being exposed to each day, the liver tries to keep pace. If the liver has a buildup of toxins like heavy metals, organophosphates, bromide, fluoride, and more, and it can’t release the toxins fast enough though, the liver becomes prime real estate for pathogens like herpes, HIV, COVID, and hepatitis B. The liver, after all, is the organ that’s responsible for breaking down antibiotics and antiviral medications that the doctor prescribes. As such, the antibiotic and antiviral effects of these medications never reach the deepest, darkest areas of the liver. So in order to do her healing work with major diseases, T. kirilowii has specialized in detoxifying the liver and killing pathogens using the medicine that it contains known as “trichosanthin”. 

Trichosanthes kirilowii, for example, clearly works to heal the liver (this herb's ability to cure hepatitis B clues us into this fact), but also the gallbladder and the pancreas to which the liver is connected directly (via the common bile duct). If we think of the liver-gallbladder-pancreas as one unit and one organ rather than as three separate organs, it simplifies the idea that if one of these organs is sick, they’re all going to suffer. In some systems of medicine, such as endobiogeny, the liver is actually viewed as two separate “organ-units” (the liver-gallbladder and the liver-pancreas) but for the sake of simplicity, in this discussion, we’re going to view the liver-gallbladder-pancreas together as just one organ-unit.

So moving on, if we allow the thought of these three organs, that all sit just under the boney bottom ridge of the rib cage, to meld into one organ-unit, we might start to appreciate how a colony of herpes viruses (or any pathogen) that live in the liver might cause a disease. If the liver tissues have been weakened in some way by a toxin like heavy metals, for example, there are likely areas inside the liver that are completely hidden from the immune system. Pathogens and also toxins could easily pass from the liver to the gallbladder or from the liver to the pancreas through the common bile duct that connects them. There are some pretty sexy fluids (like pancreatic enzymes and bile) that are constantly flowing through the common bile duct from these organs. And you can imagine how these different fluids – bile and pancreatic enzymes, for example – might backup or co-mingle accidentally such that a pathogen located in the liver might also cause infection in the gallbladder or the pancreas. 

To understand how cancer and diabetes fit into this puzzle, we have to know that cancer and diabetes are both rooted in the pancreas. When pancreatic enzymes are deficient (which might happen as a result of infection in the pancreas or due to a diet high in animal products), there is nothing in the bloodstream to patrol the body and eat away at the sheath that covers and protects cancer cells from the immune system. Dr. John Beard, an embryologist, developed the Trophoblast Theory of Cancer based on his observation that cancer cells are identical to the trophoblast cells that develop in the earliest stages of embryonic development. In embryology, trophoblast cells eventually go on to develop into the placenta. Cancer cells, in contrast, develop into false placentas that create their own blood supply (just like a placenta). Cancer cells also produce human Chorionic Gonadotropin (hCG), the same hormone being tested for in pregnancy tests. You could use a pregnancy test for cancer rather than a PET scan, MRI, or biopsy, because all cancer cells produce hCG. The only caveat is that you have to be 100% certain that you’re not pregnant in order to know whether the results of your test are accurate or not for cancer. But Dr. Beard’s Trophoblast Theory of Cancer was valuable not just because he demonstrated how easy it is to test for cancer at home, but also because he was able to cure cancer with nothing but orally administered pancreatic enzymes for his patients. As a stand-alone medicine, pancreatic enzyme therapy had a cure rate that was over 4 times higher than that of chemotherapy as a stand-alone medication. Click here to read more about Dr. John’s Beard’s Trophoblast Theory of Cancer and how to use this theory to test for cancer at home and also overcome cancer using pancreatic enzyme therapy.

Diabetes is another disease that originates in the pancreas. In conventional medicine diabetes is divided into type 1 diabetes and type 2 diabetes, but the fact is, most people have some combination of both types. Type 1 diabetes is said to occur because the body’s immune system is attacking the insulin-producing cells of the pancreas. But what if type 1 diabetes is NOT caused by autoimmunity, but rather by a pathogen that lives in the liver or in the gallbladder and that occasionally attacks the insulin-producing beta cells of the pancreas? In fact, studies have shown that a previous infection with hepatitis B virus and cytomegalovirus (a type of herpes virus) are correlated strongly with the subsequent development of diabetes. Indeed, there are other viruses that scientists have identified as possible causative agents in the destruction of insulin-producing beta cells. For more information about pathogens that cause diabetes, click here.

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Type 2 diabetes is said to involve cells that are insulin resistant / insulin insensitive. But actually, most people who have type 2 diabetes are also a bit low on insulin-producing beta cells in the pancreas too. Most people with both type 1 or type 2 diabetes have a combination of low-insulin production combined with poor insulin sensitivity at the cellular level. But we might think about diabetes type 2 as one manifestation of the Cell Danger Response. The Cell Danger Response happens when cells go into a state of dormancy, usually as a result of some trauma, either biological or psychological. The Cell Danger Response and cellular dormancy can happen as a result of toxic overload from exposure to organophosphates, bromide, heavy metals, and other chemicals or toxins, but it can also happen as a result of being inundated with disease-causing pathogens. In any case, cells that are exposed to biological traumas like this go into a state of dormancy in an effort to survive.

Psychological trauma can also cause the Cell Danger Response to occur. That’s right, emotional trauma can cause cells to go dormant. Click here to learn more about trauma: what it is and how it feels.

In Traditional Chinese Medicine, the pancreas is the organ that holds onto trauma. It’s the organ that deals with trust and distrust as well as the feeling that the world is either generally safe or generally dangerous. As you can see, the pancreas, as the insulin-producing organ, is the main structure in the body involved in diabetes, but it also happens to be true that people who develop cancer have experienced some form of emotional or biological trauma. German New Medicine is a different model of medicine that treats trauma as the core issue that causes cancer. But for our purposes here, in this article, the focus is mostly just on the idea that the pancreas is the core organ involved in diabetes and cancer.

Of course, the pancreas and the liver are connected directly via the common bile duct within which their fluids co-mingle daily. And what we’re trying to establish here is the idea that these two diseases, cancer and diabetes, develop as a result of toxic buildup of chemicals, heavy metals, pathogens, or even emotional trauma. This toxic buildup happens mostly in the liver, but it impacts the pancreas and the gallbladder too. When toxins build up, the liver gets weak and the herpes virus can make a home inside this organ more easily as a result.

Colonies of pathogens like herpes, hepatitis B viruses, HIV, and others that might be living in the liver have been heavily correlated with autoimmune diseases and “paraneoplastic diseases” that involve a dual diagnosis of cancer and autoimmune disease. Click here to read more about pathogens that cause autoimmune disease. But while most humans today believe that autoimmunity develops out of thin air despite scientific evidence to the contrary, Trichosanthes kirilowii already knew that that wasn’t true. Her explanation for such nonsense is that these diseases – cancer, diabetes, and other autoimmune diseases – are all connected via the liver, gallbladder, and pancreas – an organ-unit that is often host to colonizing pathogens that infect the body for long periods of time.

As a cure for hepatitis B, herpes, the COVID virus, and HIV after all, Trichosanthes kirilowii has liver-protective effects. It knows how to kill viruses, but also protect healthy human liver cells from becoming host to infection again. 

The plant that has the most to teach us about the cancer-diabetes connection is probably Ayahuasca, a sacred medicine that can literally talk to those who ingest her. (Click here to read more about Ayahuasca for cancer and diabetes.), but Trichosanthes kirilowii also knows how to heal the liver, the gallbladder, and the pancreas so as to overcome diabetes and cancer at the same time. Often, she overcomes these diseases by targeting low-level infectious pathogens that are hiding in the organs just underneath the rib cage. Trichosanthes kirilowii is an herbal remedy for herpes (and other diseases) that works by healing the core issue underlying the disease.

That being said, in the modern day, it’s vital that you work with more than one natural remedy for herpes, HIV, etc. at a time. For example, if you want to get rid of herpes permanently, you’ll need to work with an herb like T. kirilowii for a while, perhaps 6 months to a year. You’ll need to be consistent in dosing yourself with this herb, but you’ll also need to adhere to a healthy diet that supports the liver-gallbladder-pancreas organ-unit. The China Study Diet is a good choice because it isn’t too extreme and it has been well developed in terms of recipes.

In addition to a healthy diet, it’s also vital that patients address the emotional trauma that might be taxing the liver (which holds anger) and the pancreas (which deals with feelings of trust vs. distrust). While Trichosanthes kirilowii doesn’t release emotional trauma, as you heal your liver and your pancreas (as organs that hold and process our emotions), it will become easier to release emotional trauma using trauma-informed therapies like Eye Movement Desensitization and Reprocessing / EMDR, the DreamLight.app, or sacred medicines. You may need to work with a sacred medicine like Ayahuasca to cure herpes, cancer, diabetes, HIV, hepatitis B, or other types of disease to cross the finish line with serious health issues like these, but Trichosanthes kirilowii is a friendly herb to work with in the meantime. Ayahuasca is a medicine that often requires travel, some learning, and a bit of courage while T. kirilowii can be administered safely at home without any kind of training.

Click here to read about Ayahuasca as a cure for cancer.

Click here to read more about how Ayahuasca for herpes.

Click here to read more about how to use Ayahuasca for diabetes.

Click here to do a free trial of EMDR online.



How to Cure Herpes, HIV, Hepatitis B, Cancer, Long COVID, COVID-19, and More Using Trichosanthes kirilowii (Gua Lou)

Trichosanthes kirilowii (also known as Gua Lou) is one of the most important herbs used in Traditional Chinese Medicine (TCM). It grows in various regions in China, Eastern Mongolia, and Vietnam. Colloquially, it is often called “Chinese cucumber” or “Chinese snake gourd” but the Chinese name of the plant is gua lóu (which is used to designate the fruits of both Trichosanthes kirilowii and Trichosanthes rosthornii). The cucumber or tuber part of the plant is known as tian hua fen in Chinese. 

Extracts of T. kirilowii have the ability to damage the protein coat on the RNA of the HIV / AIDs virus. Trichosanthin is a peptide made up of 247 amino acids. Studies have shown that when the substance Trichosanthin is removed and purified from the fresh tubers of the Trichosanthes kirilowii plant, it is able to inhibit HIV replication and it is toxic to MT-4 cells at doses higher than 0.25 microgram/mL.

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In animal studies using Trichosanthes kirilowii as an herbal remedy for HSV-1 encephalitis, T. kirilowii and the substance trichosanthin was able to inactivate ribosomes. Scientists demonstrated that this anti-herpes herb was able to protect the brain against injury and encephalitis caused by HSV-1.

Trichosanthes kirilowii is an herbal remedy for Long COVID as well as an herb that can protect against COVID infection. It is also an herbal remedy for herpes and hepatitis B infection. It works as an herbal cure for Long COVID, herpes, and hepatitis B through the same mechanism of action that makes it work as an herbal cure for HIV. It has the ability to break down the protein coat that protects the RNA inside viruses that are able to colonize remote areas of the body. This herb also has the ability to detoxify the liver where colonizing viruses that cause Long COVID, herpes, and hepatitis B live.

Click here to buy Trichosanthus kirilowii / Gua Lou tincture. 



In addition to its ability to naturally cure HIV and herpes, this plant also offers the following additional medicinal benefits:
  • Long COVID cure
  • Relieves chronic constipation (root)
  • Potent anti-cancer effects (rind of the fruit) 
  • HIV cure / AIDs cure
  • Brings down fevers (leaves, stems, and root)
  • Antibacterial (fruit)
    • Echerichia coli, 
    • Pseudomonas spp.
    • Bacillus dysenteriae
    • Bacillus typhi
    • Bacillus paratyphi
    • Vibrio cholerae
    • Vibrio proteus
  • Lowers cholesterol (fruit)
  • Detoxifying (fruit)
  • Emollient (fruit)
  • Promotes sputum secretion to treat coughs and respiratory infections
  • Bronchial infection treatment (rind of the fruit)
  • Anti-cough and expectorant (seed)
  • Treats jaundice (rind of the fruit)
  • Uterine tonic (root)
  • Treats retained placenta (rind of the fruit)
  • Antibiotic (root)
  • Anti-inflammatory (root)
  • Abortifacient herb (fresh root)
  • Can help in the second stage or childbirth (fresh root)
  • Breast Cancer (root or seed can be powdered for this purpose)
  • Antiviral activity against herpes, hepatitis, and HIV 


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What You Should Know about Using Trichosanthes kirilowii to Cure HIV 

The protein trichosanthin is similar to, but just slightly different from ricin, an extremely toxic lectin found in the castor oil plant. The root extracts of Trichosanthes kirilowii are particularly toxic. Intravenous (IV) administration of the T. kirilowii root extract can cause fluid to build up around the brain or in the lungs, hemorrhaging of the brain, and heart damage. Parenteral administration (using injections or IVs) of the root extract can cause seizures and fever in HIV patients. Self-medicating with the root extract as an IV treatment to cure HIV is not advisable according to some experts for this reason. However, others note that the whole plant is regularly used in Chinese medicine as an orally administered medicine and while certain types of extracts may be toxic and the raw and unprocessed root of the T. kirilowii plant is toxic, to say that the root is always toxic in all situations is incorrect. Nonetheless, if you’re using Trichosanthes kirilowii as an herbal remedy for HIV, herpes simplex virus, or hepatitis B, it’s important to understand that this plant contains substances that could be toxic if not used in the right way.

If you are looking for a way to cure HIV, click here to learn more about Dr. Haresh, an M.D. that uses a special protocol to overcome HIV infection.

Studies have shown that trichosanthin works as an herbal remedy for HIV by inhibiting HIV1p24 antigen levels and increasing the CD4+ T cell counts in HIV-1 patients. Phase I/II clinical trials have been done to try to create a synthetic version of Trichosanthes kirilowii (by manipulating its molecular structure or make-up--in this case by coupling to PEG) that would work to treat HIV. The hope was, of course, that the T. kirilowii molecules could be changed ever-so-slightly so that they could be patented and sold at a (likely enormous) profit by big pharmaceutical companies. When this project failed, clinical trials were halted and the anti-HIV effects of the raw plant-based components in Trichosanthes kirilowii were covered up.

Click here to learn more about Chlorine Dioxide Solution as a cure for HIV. 

Click here to read more about Robert, a man who used Chlorine Dioxide Solution and other remedies to cure HIV at home.

Trichosanthes kirilowii Dose as an Herbal Cure for HIV

Trichosanthes kirilowii Dose for HIV

In clinical trials treating HIV patients, the substance trichosanthin (an isolated compound that exists naturally in the T. kirilowii plant), was administered via IV at 1.2 mg weekly and then later, monthly. Of course, as discussed above, IV therapy with T. kirilowii is not recommended. Alternatively though, you could eat T. kirilowii seeds. A different study used the seeds of the Trichosanthes kirilowii plant as a successful alternative treatment for HIV. In this study, 20 grams of the seed kernels were eaten daily for 28 days.

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Trichosanthes kirilowii: Herbal Cure for HSV, Long COVID, Cancer, and Hepatitis B 

Scientific studies have demonstrated that T. kirilowii has antiviral activity against the herpes simplex virus. It has been used to cure HSV.    It also inhibits the replication of hepatitis B virus. It can kill cancer cells. For breast tumors, T. kirilowii is an herb that prevents cancer metastasis by preventing the development of a blood supply to cancer cells. The lack of a blood supply ultimately leads to the death of cancer cells. Lung cancer and nasopharyngeal carcinomas have also been cured using T. kirilowii in studies with animals.

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Note also that paraneoplastic autoimmune diseases, especially those that involve a colonization of the hepatitis B virus or HSV would be particularly responsive to this knock-out herbal remedy for both cancer and autoimmune disease. 

Click here to read more about the various pathogens that have been scientifically studied in relation to specific autoimmune diseases.

 

Read more here about paraneoplastic autoimmune diseases that are directly linked to specific types of cancer.

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Trichosanthes kirilowii for Childbirth and Ectopic Pregnancy

Trichosanthes kirilowii can cause miscarriages and abortion, so it should NOT be used during pregnancy. However, it can be used during childbirth to promote labor and to expel the placenta after the baby has been born.

In ectopic pregnancy, trichosanthin was able to expel the embryo in 85% of 140 cases of miscarriage. According to the Trophoblast Model of Cancer proposed originally by John Beard, a British embryologist who noticed that there are important similarities between cancer cells and placental cells, because T. kirilowii has a negative impact on cancer cells, it would stand to reason that this plant (and trichosanthin in particular) would also have a negative impact on embryological development. As a general rule (though there are some exceptions), herbal remedies that cure cancer should not be used during pregnancy because of the similarities between the placenta and cancer cells.

Trichosanthes kirilowii can be used to promote labor during the second stage of childbirth and it can also be used to expel the placenta if parts of the placenta are retained after childbirth.

T. kirilowii: Herbal Remedy for Cancer

As noted above, T. kirilowii is a powerful herbal remedy for cancer. For cancer, the fruit is consumed rather than the seeds.

How Trichosanthes kirilowii Is Prepared as a Cure for Cancer

Fruits 

Young T. kirilowii fruits are typically pickled, but the pulp of the older fruits can be eaten raw. The fruit can also be prepared as a soup in the fall and winter to ward off flu and colds.

Click here to do our 1 hour QUICK START VIDEO COURSE TO CURING CANCER AT HOME.

Leaves and Shoots

The leaves and shoots can be cooked as vegetables. 

Root

The root must be harvested in the fall and cut into thick slices and then leeched. It is soaked for 5 days, changing the water each day until the root can be mashed into a find pulped. At this point, the substance can be steamed and make into cakes or dumplings. 

Seed

An edible oil can be made from the seeds of the Trichosanthes kirilowii plant.



Resources:


Ferrari, P., Trabaud, M. A., Rommain, M., Mandine, E., Zalisz, R., Desgranges, C., Smets, P. (1991). Toxicity and activity of purified trichosanthin. Retrieved October 21, 2020 from https://pubmed.ncbi.nlm.nih.gov/1892592/
Chen, G. F. et al. (2006). Protective effects of trichosanthin in Herpes simplex virus-1 encephalitis in mice. Retrieved October 24, 2024 from https://www.researchgate.net/publication/6995828_Protective_effects_of_trichosanthin_in_Herpes_simplex_virus-1_encephalitis_in_mice

Park. S. M., Jeon, S. K., Kim, O.H., Ahn, J. Y., Kim, C. H., Park, S. D., Lee, J. H. (2019). Anti-tumor effects of the ethanolic extract of Trichosanthes kirilowii seeds in colorectal cancer. Retrieved October 20, 2020 from https://cmjournal.biomedcentral.com/articles/10.1186/s13020-019-0263-8#:~:text=Since%20trichosanthis%20semen%2C%20the%20seeds,coughs%20%5B6%2C%207%5D

Plants for a Future (2020). Trichosanthes kirilowii - Maxim. Retrieved October 20, 2020 from https://pfaf.org/user/Plant.aspx?LatinName=Trichosanthes+kirilowii


Wong, K. L., Wong, R. N., Zhang, L. (2014). Bioactive proteins and peptides isolated from Chinese medicines with pharmaceutical potential. Retrieved October 21, 2020 from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110622/


He, D., Zheng, Y., Tam, S., (2012). The anti-herpetic activity of trichosanthin via the nuclear factor-KB and p53 pathways. Retrieved October 21, 2020 from https://pubmed.ncbi.nlm.nih.gov/22498878/


He, D. X., Yau, K. H., He, X. H., Shi, H. J., Zheng, Y. T., Tam, S. C. (2000-2008). Conversion of trichosanthin-induced CD95 (Fas) type I into type II apoptotic signaling during Herpes simplex virus infection. Retrieved October 21, 2020 from https://pubmed.ncbi.nlm.nih.gov/21723610/




Chen, G. F., Huang, W. G., Chen, F. Y., Shan, J. L. (2006). Protective effects of trichosanthin in Herpes simplex virus-1 encephalitis in mice. Retrieved October 20, 2020 from https://pubmed.ncbi.nlm.nih.gov/16787600/


Zhenga, Y. T., Chanb, W. L., Chanc, P., Huangb, H. Tamb, S. C: (2001). Enhancement of the anti-herpetic effect of trichosanthin by acyclovir and interferon. Retrieved October 21, 2020 from https://febs.onlinelibrary.wiley.com/doi/pdfdirect/10.1016/S0014-5793%2801%2902391-2

Lo, H. Y. et al. (2017). Hypoglycemic effects of Trichosanthes kirilowii and its protein constituent in diabetic mice: the involvement of insulin receptor pathway. Retrieved October 24, 2024 from https://pmc.ncbi.nlm.nih.gov/articles/PMC5242006/

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