7,8-dihydroxyflavone is derived naturally from Tridax procumbens.Regrow Brain Cells Naturally Using 7,8-Dihydroxyflavone
7,8-dihydroxyflavone was originally developed by scientists who were looking for a cure for dementia, brain injury, and strokes. These scientists had noted the value of Brain Derived Neurotrophic Factor (BDNF) in regrowing brain cells in dementia patients, but natural BDNF has a very short half life and delivering BDNF as a natural substance to patients had disappointing results. The BNDF never really made it to the target areas of the brain. It was for this reason that scientists began investigating the development of a peptide that could mimic the effects of BDNF in the body to interact with the TrkB receptor (the main signaling receptor for BDNF) and promote the regrowth of brain cells.There were two lead compounds developed through this research into BDNF: 7,8-dihydroxyflavone and deoxygenunin. Both of these compounds bind to the TrkB receptor to activate downstream signaling cascades that cause new brain cells to grow. Of the two, 7,8-dihydroxyflavone has been studied the most extensively.
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7,8-dihydroxyflavone is also known as “tropoflavin”. It occurs naturally in the following plants:
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- Primula leaves
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- Tridax procumbens
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- Godmania aesculifolia
7,8-dihydroxyflavone can be taken orally and it is able to penetrate the blood-brain barrier. 7,8-dihydroxyflavone can be used to treat any of the following diseases and disorders by regrowing brain cells that have been damaged or that have become diseased:
- Central nervous system disorders
- Neurological disorders
- Depression
- Anxiety
- Post-Traumatic Stress Disorder (PTSD)
- Alzheimer’s Disease
- Amyotrophic Lateral Sclerosis (ALS)
- Schizophrenia (used to treat cognitive deficits that result from this disease, not the other symptoms)
- Parkinson’s Disease
- Lewy Body Dementia
- Traumatic Brain Injury
- Cerebral Ischemia / Stroke
- Fragile X Syndrome
- Autism
- Epilepsy
- Rett Syndrome
- Obesity
- Insulin Impairments
- Cognitive Impairments
- Memory Problems
- Emotional Problems
- Protects against glutamate-induced excitotoxicity
- Protects against 6-hydroxydopamine-induced dopaminergic neurotoxicity
- Protects against oxidative stress in the brain
- Blocks methamphetamine-induced dopaminergic neurotoxicity
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7,8 Dihydroxyflavone as a Natural Nootropic
7,8 dihydroxyflavone is a natural flavonoid that mimics the effects of Brain Derived Neurotrophic Factor (BDNF). 7,8 Dihydroxyflavone is able to to cross the blood-brain barrier.This peptide is neuroprotective and it has been studied a great deal in relation to memory and dementia-related mental health issues including Alzheimer’s, Parkinson’s disease, and Lewy Body Dementia. More recently, scientists have begun studying 7,8-dihydroxyflavone to determine whether its ability to rebuild brain tissues and promote plasticity might be useful in treating Post-Traumatic Stress Disorder (PTSD). It has been used to reduce the cognitive deficits associated with schizophrenia and it has also shown promise as a healing agent for autism and epilepsy.
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- Amygdala
- Hippocampus
- Prefrontal Cortex
Problems with BDNF/TrkB (tropomyosin receptor kinase B) signaling is correlated with several severe mental health problems including schizophrenia as well as PTSD. 7,8-dihydroxyflavone functions as a TrkB agonist after it crosses the blood-brain barrier. Essentially, it mimics the action of BDNF to promote the healthy growth of brain tissue.
7,8-Dihydroxyflavone as a Natural Treatment for Schizophrenia
This peptide promotes spatial working learning abilities. Studies have shown that activation of TrkB signaling reverses the cognitive deficits of schizophrenia. Scientists note that this peptide could be useful as a natural cure for schizophrenia and mental health issues that involve similar cognitive impairments as schizophrenia.
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How BDNF-TrkB Signaling Is Able to Reduce PTSD Symptoms Naturally: How to Get Over PTSD on Your Own
Tropomyosin Receptor Kinase B (TrkB) is the receptor for Brain Derived Neurotrophic Factor (BDNF). When BDNF interacts with a TrkB receptor, the brain becomes more “plastic”. It’s easier for people to change their minds and their thoughts when the BDNF-TrkB signaling pathway is healthy and working well. It’s a well-known fact that trauma can change the way that the BDNF-TrkB signaling pathway works which in turn leads to changes in the following brain structures:
- Amygdala
- Hippocampus
- Anterior Cingulate Cortex
- Ventromedial Prefrontal Cortex
- Nucleus accumbens
Changes to these brain structures in turn, cause many of the symptoms of PTSD including intrusive memories, hyperarousal, increased levels of fear, and emotional numbing. Studies have indicated that 7,8-dihydroxyflavone can speed up the process of fear extinction in those with PTSD by mimicking the effects of BDNF. As such, this is an important PTSD supplement that can improve and speed up results from other forms of therapy.
When used in combination with treatments such as neurofeedback therapy, online Eye Movement Desensitization and Reprocessing (EMDR), Wim Hof breathwork and cold therapy, and Internal Family Systems therapy, 7,8-dihydroxyflavone can help individuals treat PTSD naturally without drugs. 7,8-dihydroxyflavone works by providing PTSD patients with new synaptic connections that give them an escape route out of their normal fear response. When used in combination with any of the above treatments, 7,8-dihydroxyflavone improves results and speeds up the process of recovery.
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Prevent Epilepsy Naturally Using 7,8-Dihydroxyflavone
Temporal lobe epilepsy is a condition that often develops many months or years after an initial seizure, stroke, or brain injury. In conventional medicine, there is no way to prevent epilepsy after the first seizure occurs, but scientists have recently found that 7,8-dihydroxyflavone functions as a natural anti-epilepsy medicine.Scientists who have studied 7,8-dihydroxyflavone for its ability to prevent epilepsy naturally have noted that low doses (5 mg per kg of the patient’s body weight) of this substance act as an epilepsy preventative. In contrast, high dose 7,8-dihydroxyflavone (10 mg/kg) can act as a pro-epilepsy substance. Low dose 7,8-dihydroxyflavone (5 mg/kg) significantly reduces the frequency of spontaneous seizures and it significantly lengthens the period of time between when status epilepticus occurs and the first seizure afterward. Scientists have suggested that this natural substance be developed into a pharmaceutical medication, but in reality, as a naturally occurring substance, 7,8-dihydroxyflavone is safer in its natural form. Of course, if you are searching for a way to cure epilepsy, you should also read more about the herb Acorus calamus. This herb has a long history of use as a cure for epilepsy. Also make sure to read here about another known cause of seizures that can be treated or that can lead to a spontaneous epilepsy cure in up to 60% of patients who are diagnosed with epilepsy. Click here to read about how to use the herb Acorus calamus to treat epilepsy naturally.
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7,8-Dihydroxyflavone as a Natural Treatment for Osteoporosis
Osteoporosis is ultimately caused by vitamin K2 deficiency, but there are other health conditions that can lead to imbalances in bone formation and bone resorption that leads to weakened bone tissues. Indeed, Brain Derived Neurotrophic Factor (BDNF) plays a role in bone health. Scientists have been able to show that both natural BDNF and 7,8-dihydroxyflavone promote the growth and differentiation of bone cells and the remineralization of bone tissues.As an alternative to bisphosphonates, the toxic drugs that are most commonly prescribed to treat osteoporosis, the combination of vitamin K2 and 7,8-dihydroxyflavone can significantly improve mineralization of bone naturally within 6 weeks or less as well as improving the trabecular microarchitecture.
Click here to read about vitamin K2 as a cure for osteoporosis.
Click here to read more about bisphosphonate drugs that are used to treat osteoporosis.
7,8-Dihydroxyflavone as an at-Home Methamphetamine Addiction Treatment
7,8-dihydroxyflavone is a substance that blocks neurotoxicity caused by the use of meth. As such, this substance can be used with Mucuna pruriens and other anti-addiction herbs like Kudzu or 5-HTP to significantly reduce withdrawal symptoms from meth while rebuilding the brain and dopamine neurons at the same time.Click here to read more about how to overcome meth addiction at home.
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7,8-Dihydroxyflavone as a Natural Cure for Dementia
Alzheimer’s disease is an iconic form of dementia, but 7,8-dihydroxyflavone provides benefits for any kind of dementia that involves brain cell atrophy or amyloid development. If you or a loved one is diagnosed with dementia, it’s important to find good research and treatments that will work quickly to cure the disease.If you’ve just received the diagnosis, consider administering vitamin B12 to determine whether vitamin B12 deficiency is the root cause of the dementia. Note that often, lab reports are not correct in reporting on whether a patient actually has a vitamin B12 deficiency or not. We have worked with several patients who were told that their vitamin B12 lab results were okay through one lab and through a different lab, their vitamin B12 levels were low.
But if you’ve already had a vitamin B12 shot and dementia symptoms stayed the same, then it’s time to move on to other cures for dementia that will help your brain rebuild and become healthy again. 7,8-dihydroxyflavone is one of those substances that can help the brain regrow cells. Also note that vitamin K2 can help improve blood circulation to the brain which has been shown to generally improve all forms of dementia. Click here to read more about how vitamin K2 can improve dementia symptoms naturally.
Again, 7,8-dihydroxyflavone is a substance that simply helps the brain perform better by promoting healthy cell growth. As such, it is a good choice for all types of dementia.
Click here to read more about the link between dementia and osteoporosis.
Click here to read about the use of dimethylsulfoxide (DMSO) to cure Alzheimer’s disease naturally.
Click here to read about how to use chlorine dioxide solution and DMSO to cure dementia naturally.
Click here to read about how vitamin B12 deficiency can mimic the symptoms of dementia and how to use vitamin B12 as a natural cure for dementia.
7,8-Dihydroxyflavone Dosing:
7,8-dihydroxyflavone is able to cross the blood-brain barrier when it is administered either intraperitoneally or orally. Administer this peptide at 5 mg / kg of the patient’s body weight for 14-28 days.
Half-life of 4-8 hours in monkeys -- it is probably similar in humans.
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Resources:
• Yang, S. and Zhu, G. (2022). 7,8 Dihydroxyflavone and Neuropsychiatric Disorders: A Translational Perspective from the Mechanisms to Drug Development. Retrieved September 20, 2023 from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881092/#:~:text=Studies%20have%20shown%20that%207,PTSD%20%5B161%2D165%5D.
• Andero, R. et al. (2014). BDNF- TrkB receptor regulation of distributed adult neural plasticity, memory formation, and psychiatric disorders. Retrieved September 20, 2023 from https://pubmed.ncbi.nlm.nih.gov/24484701/
• Zeng, Y. et al. (2013). Activation of TrkB by 7,8-dihydroxyflavone prevents fear memory defects and facilitates amygdalar synaptic plasticity in aging. Retrieved September 20, 2023 from https://pubmed.ncbi.nlm.nih.gov/22710915/
• Yang, Y. J. et al. (2014). Small-molecule TrkB agonist 7,8-dihydroxyflavone reverses cognitive and synaptic plasticity deficits in a rat model of schizophrenia. Retrieved September 20, 2023 from https://pubmed.ncbi.nlm.nih.gov/24662915/
• Green, C. R. et al. (2014). The Role of BDNF-TrkB Signaling in the Pathogenesis of PTSD. Retrieved September 20, 2023 from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161201/
• Lavars, N. (2021). Mitochondria discovery reveals a plant extract that could combat obesity. Retrieved September 20, 2023 from https://newatlas.com/medical/plant-flavone-mitochondria-function-obese-mice/
• (2022). Low-dose 7-8-Dihydroxyflavone Administration After Status Epilepticus Prevents Epilepsy Development. Retrieved September 20, 2023 from https://link.springer.com/article/10.1007/s13311-022-01299-4
• Xue, F. et al. (2021). 7,8-dihydroxyflavone modulates bone formation and resorption and ameliorates ovariectomy-induced osteoporosis. Retrieved September 20, 2023 from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285109/
• Chen, C. et al. (2018). The prodrug of 7,8-dihydroxyflavone development and therapeutic efficacy for treating Alzheimer’s Disease. Retrieved September 20, 2023 from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777001/
