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What is a Healing Crisis? (aka Herxheimer Reaction, Detox Reaction, or Die-Off Reaction)

Posted By Jennifer Shipp | May 06, 2014

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A detox reaction can feel a lot like the flu. In fact, often people think that they've caught the flu, but actually, their body is just overwhelmed with toxicities that are being removed quickly. One of the most helpful tools to get through detox quickly is an enema, which keeps toxins moving out of the body to hasten your recovery.

What is a Detox Reaction (aka Die-Off Reaction)?

We’ve all been taught to believe that when our bodies feel good, we’re healthy and when our bodies feel bad, we’re sick. But this simply isn’t always the case.  A “healing crisis” (also known as a “detoxification reaction” or “Herxheimer reaction”) happens when the body begins the natural process of healing itself by removing toxins and pathogens. When toxins are released into the circulatory system by pathogens that are dying, rather than feeling better, a patient who is going through a healing crisis feels worse (at least at first). That’s because the kidneys, liver, skin, and digestive system can’t rid the body of the toxins fast enough, leaving them in circulation causing nausea, fatigue, headaches, fever, and general malaise.  Toxins that are released into circulation can come from a variety of different sources. A successful program designed to kill off invading pathogens in the body can lead to a Herxheimer Reaction when the pathogens die in vast numbers and release endotoxins into the body.  When the body isn’t used to ridding itself of these endotoxins in large quantities, discomfort results. As the body gets healthier and becomes more accustomed to undertaking this process of detoxification, the healing crisis becomes less pronounced. Detoxification reactions are not widely acknowledged in modern medicine though there are some diseases like Lyme disease, syphilis, or other spirochete diseases that involve a detox reaction as part of the healing process. In spirochete infections, the reaction is known as a Jarish-Herxheimer reaction. Nonetheless, healers outside of conventional medicine acknowledge that Herxheimer reactions can even occur in response to powerful hypnotherapy treatments like cellular release therapy, for example. In fact, detoxification (especially detoxification that is “blocked”) is the cause of many (but not all) symptoms of illness.

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Most Common Symptoms Associated with the Healing Crisis:



  • Crisis: 

    • Nausea and vomiting
    • Diarrhea
    • Increased Blood Pressure
    • Headaches
    • Fatigue
    • Night Sweats
    • Hot or Cold Flashes
    • Hyperventilation
    • Myalgia
    • Joint Pain
    • General feeling of malaise
    In other words, if you are trying to reduce your worm load, or if you are self-treating to get rid of another type of parasite infection at home, you may feel really awful because you are starting to get better. Detoxification reactions are one of the reasons why we recommend that patients with parasites always keep a journal of their daily symptoms. A strong detox reaction can cause a patient to feel as though they’re getting worse when, in fact, the patient is actually making progress and getting better Ideally, there will be someone in your life (an acupuncturist, a health coach, or a healing practitioner that you trust) who will be able to help you discern whether you are getting worse or getting better. By keeping a journal of your daily symptoms, you can have a very grounded conversation with a trusted person in your life who is not infected with parasites about what’s actually happening on the days when you feel like your symptoms are getting worse. 


Other Healing Crisis Causes:



A number of treatments can set off a healing crisis, from Kangen Water / Molecular Hydrogen to the use of MMS (Miracle Mineral Solution) / CDS (Chlorine Dioxide Solution). Even sunlight exposure can cause a detoxification reaction because of sunlight's healing effects on the liver. (Note that a detox reaction from sunlight exposure looks a lot like a sunburn; read more about the power of sunlight as a healing medicine here). Reiki and acupuncture can both elicit a detox reaction associated with healing. Homeopathy and the act of fasting or juicing can also bring on this kind of reaction. A Herxheimer reaction can take place in response to physical, emotional, or spiritual healing. Even certain hypnotherapy or psychotherapy treatment methods can cause a detoxification reaction brought on by profound emotional healing. A change to your diet that includes the addition of foods that contain probiotics or coconut, or recently added herbal or vitamin supplements to your daily regime can bring on a healing crisis as well. As an example of this, iodine deficiency, when corrected, often results in a bromine detox. When iodine isn't present in the body in high enough quantities, bromine / bromide from the environment is able to take over the iodine receptors and thus cause illness and disease. When a person supplements with sufficient amounts of iodine, the bromine / bromide has to leave the body as the iodine replaces it. On its way out, bromine / bromide often causes a detox reaction. You can read more about this particular process here If you find yourself in the throes of a major healing crisis, back off a little bit on the detoxification process. Drink plenty of water, do a coffee enema, and get plenty of rest to facilitate the healing process and move past the Herxheimer reaction to a healthier you. 

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What to Expect During a Detoxification Reaction:

The treatments we recommend to clients typically involve a “tear down” and then a “rebuild” process. In other words, you’ll feel worse before you feel better. Keeping a journal will help you see the pattern and notice how following a detox, you feel better than you did before the detox. Many people get confused when they go through a detoxification reaction and feel like they’re getting sicker without realizing that the process of purging (diarrhea, vomiting, increased urination, and even fevers and achiness) are all part of a process of throwing off toxins and getting rid of pathogens including parasites.   If your body has been debilitated by a lack of certain nutrients (vitamin B17, for example, or iodine and vitamin K2), your body will try to keep things running smoothly by substituting other nutrients. It’s a bit like trying to build a snow fence using toothpicks and dental floss during a blizzard. If the body doesn’t have the proper nutrients, it’s hard to properly protect the body from infection. It works with what it’s been given. The body uses what it has available at the time, but when the proper nutrients become available, tissues that are not “properly built” may be deconstructed and rebuilt. As the old, in appropriate materials are thrown off, patients may experience a detox reaction.  A NOTE ABOUT REVERSE CYCLING - Expect to go through a “tear down” and then “rebuild” process where you revisit disease states that you’ve experienced in the past including a worsening of your disease symptoms. If you  experience stronger symptoms or if you experience symptoms of past disease states, this is likely a form of “reverse cycling” that occurs as the body returns to a state of health.  An example of reverse cycling happens, for example, when a person has cancer and they take ESSIAC tea as a treatment. ESSIAC causes cancer cells that have metastasized to other areas of the body, to return to the original cancerous tumor. The original tumor gets bigger and bigger as the metastasis is reversed. This can be dangerous if the tumor is located in the brain or in an area of the body that can be blocked by an enlarged tumor. But, for example, if the original tumor is located in the breast or in some other area where enlargement is not an issue, the original tumor gets bigger right before it disintegrates completely. Nonetheless, enlargement of the original tumor is scary and many patients go to a doctor to find that their tumor is bigger as a result of taking ESSIAC and the patients then believe that they are getting worse. In reality, they are approaching a cure. 



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The Liver / Gallbladder / Pancreas: Enzyme Therapy and Detoxification

Though it may not seem like your liver/gallbladder is involved in your parasite infection, many pathogens retreat to the liver when people use prescription antibiotic / antiparasitic / antimicrobial therapies because the liver is somewhat immune to these substances by virtue of its detoxification function in the body. The liver is literally responsible for breaking down prescription antibiotics. The gallbladder is the liver’s sidekick and it stores bile from the liver so it is often involved in harboring pathogenic “refugees” too that have migrated from an original site of infection to the safe harbor of liver and gallbladder tissues.  The pancreas gets involved via the ductwork which connects the liver, gallbladder, and pancreas such that all of the enzymes from these organs dump through a single shared duct. A clog in the duct or pathogens in one organ can lead to problems in the other organs too via the ductwork.   In reality, you may or may not need enzyme therapy to overcome a parasite infection. However, enzymes are some of the most difficult substances that the body must produce to stay alive, so we often recommend the use of supplemental enzymes for the first few months of treatment to restore more balanced digestive system function. It takes a lot of energy to make enzymes and clients that eat a lot of meats or animal products use a lot of enzymes too which can be generally debilitating. People who eat a plant-based diet may suffer from enzyme deficiencies for other reasons. Taking enzymes helps people digest their food and absorb it better.  Be aware though, that enzymes work on more than just the digestive system. As an example, ox bile supplements can act as a cure for psoriasis. Using nothing but ox bile as a supplement, about 80% of people with psoriasis can be cured according to scientific studies. So ox bile supports the liver, but it works throughout the body to relieve psoriatic arthritis and skin eruptions as well as digestive upsets common in psoriasis patients. Pancreatic enzymes, in contrast, can be used to cure cystic fibrosis, a serious lung disease that involves fibrosis. Indeed, pancreatic enzymes and lung health are intimately connected, but pancreatic enzymes and fibrotic diseases that involve an overgrowth of tissue either malignant or benign are also related. In the early 1900’s (prior to the advent of the AMA) pancreatic enzymes were being used as a stand-alone cancer cure with a 13-65% cure rate that dwarfs the stand-alone “cure” rate for chemo (which is only 2-3%). Pancreatic enzymes dissolve fibrotic growths that can create pressure on neighboring organs.  Needless to say, enzyme therapies can help the body detox more efficiently but the enzymes also promote health through other mechanisms of action throughout the body.  Taking enzymes can absorb all of your vitamins and minerals. It’s important that the food that you eat digests properly and that you are able to absorb the nutrients to ensure that your body will rebuild. It may also help with digestive problems that you have by facilitating digestion in a general way. Enzymes can promote good digestion while they ease detoxification, promote tissue rebuilding, and also support liver, stomach, intestine, and pancreatic health.   Below are the enzymes that we recommend: 
  • Betaine / Pepsin - Take this before, during, or right after meals for feelings of “fullness” after eating or if you suffer from indigestion. It works on the first stage of digestion in the stomach.




Sometimes the liver/gallbladder puke out bits and pieces of a pathogen in the form of peptidoglycans that are EXTREMELY irritating to human tissues. In the intestines, bile works like a detergent to clean the gut and it also digests pathogenic material down to harmless bits and pieces that can be removed from the body. If you have too little bile, a variety of diseases develop due to a deficiency of fat soluble vitamins as well. Take 125 - 500 mg of ox bile with every meal.
  • Pancreatic Enzymes: When there’s an excess of pancreatic enzymes, they’re absorbed into the blood where they function as antimicrobials in our blood by dissolving the outer membrane of pathogens and cancer cells. Below are supplements we recommend to our clients to support the pancreas:


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How to Detoxify / Remove Pathogens and Gallstones from the Liver / Gallbladder

I If you do in fact, still have a pathogen of some kind living in your liver or gallbladder, detoxification of these organs is important. At first, gallstones that may be clogging the ducts need to be removed. This is relatively easy and painless using the Hulda Clark Gallbladder Cleanse and Coffee Enemas Dr. Hulda Clark was an important medical professional who acknowledged the ubiquitous nature of parasites in humans. She also acknowledged that parasites can cause a wide range of diseases and symptoms that conventional doctors often overlook or misunderstand. Dr. Clark’s gallbladder cleanse is an important treatment for anyone with a parasite infection as it can help remove bile sludge, gallstones, and parasites that might be clogging ducts. When enzymes are blocked by parasites in the ducts, this can lead to more serious symptoms of disease.  Coffee enemas were recommended by Dr. Gerson, a famous doctor who developed a special juice-fasting protocol with supplements to overcome cancer. Coffee enemas help the liver release bile sludge and toxins and they can also help the body remove biofilm more quickly.  Both coffee enemas and the Hulda Clark gallbladder cleanse are recommended for those who wish to spend less time languishing in states of detoxification that can be rather uncomfortable during the healing process. Do up to one Hulda Clark cleanse monthly and coffee enemas up to 3 times per day during the first 3 months of treatment for a major disease, including for parasite infections.

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Resources

Clark, H. (1994). The Cure for All Diseases: With Many Case Histories. New Century Press: Chula Vista, CA. Wood, J. M. and Sbar, E. (2025). Jarish-Herxheimer Reaction. Retrieved March 17, 2026 from https://www.ncbi.nlm.nih.gov/books/NBK557820/ 



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