Kola Nut: Anti-Snake Venom Activity and Antidote to Chronic COVID Spike Protein Health Issues
Black cobras and krait snakes are both elapids with alpha-bungarotoxin that can block nicotinic receptors to cause issues that are similar to post-COVID vaccine injury and Long COVID.The COVID Spike Protein and Snake Venom
The COVID spike protein is nearly identical to substances found in krait snake venom and it warrants mention that Garcinia cola / bitter kola nuts can specifically protect human cells from the COVID spike protein, and that the kola nut is also used to neutralize snake venoms. There's a relationship between herbal antidotes for elapid snake venom (alpha-bungarotoxins specifically) and herbal remedies for COVID spike protein-related health issues. Krait snake venom contains neurotoxins that are similar to that of other elapid snakes such as sea snakes and cobras. Garcinia cola acts to neutralize black cobra venom, a venom with characteristics that are very similar to krait snake venom, the venom that is nearly identical chemically to the spike protein.
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While most people who live in developed countries are not in danger of being bitter by a black cobra (Naja nigricollis) or a krait snake, they are in danger of illness from COVID spike protein exposure.
Garcinia kola specifically acts to inhibit hydrolytic enzymes of the Naja nigicollis snake. Kola nut neutralizes the following negative effects of a Naja nigricollis snake bite:
- Myotoxic / toxic effects against muscle tissues
- Edemic / fluid inflammation of the tissues
- Abnormal or pathological blood clotting effects
It stands to reason that Garcinia kola / Cola acuminata would also inhibit these same effects due to the COVID spike protein in those who have suffered COVID vaccine injury or long COVID. In certain areas of Africa, Garcinia cola is an essential herbal remedy for snake bites, but in the western world, this herb can presumably help diminish the effects of post-COVID vaccine syndrome and long COVID by neutralizing spike protein effects and interactions with the nicotinic receptors in the body.
Click here to read more about nicotine and muscarine for Long COVID and post-COVID vaccine injury.
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Garcinia kola: Herbal Remedy for COVID Vaccine Injury, Long COVID, Mental Illness, and Dementia
Snake venoms often have an impact on the nervous system. Elapid snakes (cobras, sea snakes, and the infamous krait snake) release a venom that impacts nicotinic receptors of the cholinergic nervous system. Alpha-bugarotoxin is the substance that specifically binds to the nicotinic receptors, blocking nerve transmission in the cholinergic nervous system (the part of the nervous system that responds the neurotransmitter acetylcholine) to cause the symptoms of “Totally Locked In Syndrome”. Totally Locked In Syndrome happens when the nicotinic receptors are overwhelmed by a substance that lodges itself in them and blocks the acetylcholine neurotransmitter from transmitting nerve impulses. This syndrome involves the paralysis of all of the muscles of the body, including the diaphragm which can lead to respiratory failure. A person who is bitten by the snake can still feel pain and they are still fully conscious, but unable to move the body, including the respiratory muscles that make it possible to breathe. At some point, even eye movements become paralyzed.Garcinia kola is an herb that has an important impact on the cholinergic nervous system. As we discussed above, the kola nut is used as an antidote to snake venom and it may also be beneficial in overcoming issues related to the COVID spike protein. Specifically, kolaviron, a substance in the bitter kola nut that has been studied extensively, acts as an acetylcholinesterase inhibitor.
Acetylcholinesterase is the enzyme that cleaves acetylcholine to release it from receptors and recycle its parts. This enzyme is important in making sure that cholinergic receptors are not overstimulated by too much acetylcholine interaction and also that they are not understimulated due to a lack of recycled acetylcholine. The cholinergic nervous system consists of two types of receptors: 1) the nicotinic receptors that are responsive acetylcholine and also nicotine along with other substances or toxins that resemble nicotine chemically and 2) the muscarinic receptors that are responsive to acetylcholine and also muscarine as well as other substances or toxins that resemble muscarine chemically. Nicotinic receptors, when overstimulated by a nicotinic toxin (such as krait snake venom) can “lock the consciousness into the body” such that a person’s consciousness can’t interact with the outside world. In contrast, muscarinic receptors, when overwhelmed by a muscarinic toxin, can “lock the consciousness out of the body” such that every fluid producing tissue “flows” with mucus and fluids. Muscarinic toxins like organophosphates cause diarrhea, urination, extreme salivation, skin redness, prolific eye watering and runny nose, and vomiting.
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Acetylcholinesterase is essential in normal nervous system transmission and general health, but this enzyme also exists in snake venom, for example. It acts to break down natural acetylcholine that might try to dock into the nicotinic receptors to help a person who’s been bitten by a snake continue to breathe. The neurotransmitter acetylcholine that causes a balanced nervous system response as we go about our daily lives. The combination of a nicotinic toxin like alpha-bungarotoxin and acetylcholinesterase in snake venom can be lethal as it paralyzes the body.
Long COVID victims and people who have suffered COVID vaccine injury often find that low-dose nicotine (from a third-step 7 mg nicotine patch) helps to reduce symptoms caused by COVID spike proteins lodging themselves in nicotinic receptors. But Garcinia kola also seems to assist with balancing the cholinergic nervous system as an herb that contains an acetylcholinesterase inhibitor. By inhibiting the enzyme that breaks down acetylcholine, Garcinia kola is able to facilitate a longer docking of the acetylcholine neurotransmitter in the the nicotinic and muscarinic receptors.
A number of neurodegenerative diseases like dementia, Parkinson’s disease, and Alzheimer’s disease involve issues with acetylcholinesterase levels that are too high.Kolaviron is also an anti-amyloid herb that has the ability to deconstruct assembled Aβ particles. As such, kola nut is a viable herbal remedy for dementia.
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The kola nut has also been used to protect the body, brain, and nervous system, from certain neurotoxins including herbicides and insecticides. For example, kola nut can be used to protect the nervous system from the negative effects of atrazine exposure. Scientists believe that it works by acting as a powerful antioxidant, anti-inflammatory, and anti-apoptotic agent that prevents nerve cell death, protects the myelin sheath around nerves, and inhibits inflammation.
Kolaviron, a biflavonoid substance found in kola nut, is believed to be the acetylcholinesterase inhibitor in bitter kola nut. Acetylcholinesterase normally reduces the amount of time that acetylcholine can spend interacting with cholinergic receptors in the nervous system, but kolaviron has the ability to inhibit this enzyme and thus increase acetylcholine transmission in the body.
Garcinia kola tends to positively impact the hippocampus and the cerebellum as a part of its medicinal effects. The hippocampus is a part of the limbic system that plays a role in spatial navigation, emotional processing, and memory formation. The hippocampus and cerebellum play a vital role in mental health. These are parts of the brain that play a big role in stress and trauma (or our ability to overcome and deal effectively with stress and trauma). Studies have shown that at a dose of 200 mg/kg body weight, Garcinia kola can mitigate the toxic effects of certain substances on the hippocampus and cerebellum.
Using Garcinia kola to Avoid COVID Complications / Pre-Treatment with Garcinia kola
Studies have shown that complications of severe COVID infections like acute respiratory distress syndrome (ARDS) and organ damage is due to spike-protein S1-induced production of increased levels of pro-inflammatory cytokines. Garcinia kola and a substance found in the bitter kola nut known as garcinoic acid can significantly reduce the expression of pro-inflammatory cytokines. Also, pre-treatment with Garcinia kola prior to infection with COVID led to reduced damage to lung epithelial cells during infection.
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Resources:
• Leitzke, M. et al. (2025). Long COVID– a critical disruption of cholinergic neurotransmission? Retrieved March 10, 2025 from https://link.springer.com/epdf/10.1186/s42234-025-00167-8?sharing_token=TSZyCVMBnNQ3QU66bTbch2_BpE1tBhCbnbw3BuzI2RODgDvexwIfZcmAmE9qMYfMU9pdczT02PpW41BXXvHcouP-ACB_4it1jhMLTjDnNAwPoQMKWRkkJTOewKQz5cpt4JPAghC2lN4ibwP1ZCrjuvi5dv9UFw85Uy3f3vwo7yM%3D
