N-Acetyl-Cysteine Use During Pregnancy
N-Acetyl-Cysteine, also known as NAC has been used in a number of contexts involving women’s health. This over-the-counter supplement has been used with great success to improve fertility in women who are having trouble becoming pregnant. It has also been used to naturally treat unexplained recurrent miscarriage in women who have trouble carrying their pregnancy beyond 20 weeks. NAC has been shown to protect babies from intra-amniotic infections and it has been used successfully as a treatment by women who are experiencing postpartum depression, NAC can significantly and naturally improve mood. If you’re pregnant, it pays to have NAC in your medicine cabinet, but this supplement can also be taken throughout pregnancy to prevent COVID or infection with a cold or the flu. It can be used as a natural home remedy for headaches during pregnancy as well. NAC has beneficial health effects for both mother and infant.
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Though NAC has been studied scientifically in great detail, L-Cysteine is an alternative to NAC that works just as well and that may even be more beneficial in terms of improving health during pregnancy. Both NAC and L-Cysteine provide a source of sulfur to the body and both also promote the production of glutathione, the body’s most important detoxifying substance. NAC is a bit more familiar to the general public, but technically NAC is synthetically derived from L-Cysteine. As such, L-Cysteine would be the preferred supplement to use during pregnancy unless you are the type of person who prefers to follow the scientific literature in a dogmatic way. NAC is something that was produced by Big Pharma, which is why it has been studied so extensively. L-Cysteine, the natural amino acid that our body uses to detoxify and fight infection, has not been scientifically funded for research to the same extent, though it likely functions even better than NAC in treating the various health issues that we talk about below.Nonetheless, it’s up to you to decide whether you prefer to use NAC or L-Cysteine during pregnancy. Both are safe and both produce valuable medicinal effects during pregnancy.
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NAC: Unexplained Recurrent Miscarriage Natural Treatment
Scientific studies have shown that N-acetyl-cysteine (NAC) can be used as a natural treatment for unexplained recurrent miscarriage. One study, which was performed at the Women’s Health Centre at Assiut University in Egypt involved one group of 80 women with a history of unexplained recurrent miscarriage who were given a combination of 600 mg of NAC plus 500 mcg of folic acid daily. These women were compared to a group of 86 women who were given just 500 mcg of folic acid daily without NAC. The NAC + folic acid group of women had a significantly increased success rate at carrying their pregnancies beyond 20 weeks. And the combination of NAC + folic acid in the group of 80 women also significantly increased the number of live births in comparison with the group of women who were given only folic acid.
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Infection or inflammation in the amniotic sac or fluids that surround a fetus can lead to preterm delivery with a higher than average risk of complications for the baby. Researchers at the University of Illinois and Yale have found that NAC can be used to cure intraamiotic infection as well as intraamniotic inflammation during pregnancy. This is a treatment that doctors may not think to use for prevention of intraamniotic infection or inflammation, but you can safely use it at home by taking 600 mg daily.In a study published by the American Journal of Obstetrics and Gynecology, 68 women were diagnosed with intraamniotic infection or intraamniotic inflammation. These women were separated randomly into two groups. One group received NAC for 10 weeks prior to preterm delivery. The other group received a placebo. The women who were given NAC had significantly fewer negative outcomes than women who did not receive the NAC. In total only 12% of women who were given NAC had negative outcomes as a result of the intraamniotic infection or inflammation in comparison with 32% of women who did not receive NAC treatments.
One of the benefits of NAC during pregnancy is the fact that it is a safe medicine that doesn’t increase the risk of sepsis or other health issues in infants.
NAC: COVID During Pregnancy Home Remedies
N-acetylcysteine or NAC has been used successfully as a safe treatment for COVID during pregnancy. NAC works as a treatment for COVID via its antioxidant, anti-inflammatory, and immunomodulating characteristics. It can be taken both to prevent COVID infection naturally during pregnancy as well as to treat COVID naturally during pregnancy.COVID infection often involves copious mucus secretion and the formation of a hyaline membrane that can cause acute respiratory distress syndrome. In pregnancy, acute respiratory distress syndrome and mucus secretion can be harder to treat and to prevent using conventional medicine because many COVID treatments are toxic to the fetus. But NAC is an exception. NAC is safe for both mother and infant and indeed, it can be taken throughout pregnancy to prevent COVID and other health problems.
NAC is an over-the-counter supplement that supplies the body with the precursor ingredients to produce glutathione, the body’s primary detoxifying agent. So this supplement helps to remove toxins that can buildup in the body to worsen COVID and other health issues that involve the detoxification process. The multi-organ injuries caused by COVID are associated with a cytokine storm that can be mitigated to some extent by NAC. NAC decreases TNF-α, IL-1β, IL-6, IL-8, IL-10, and IL-17 during a cytokine storm which might explain why this supplement is so useful as a home remedy for COVID during pregnancy. In addition to its ability to reduce the impact of a cytokine storm, NAC also improves the flow of mucus to relieve bronchitis and improve breathing during COVID. And finally, NAC has an antiviral effect that makes it ideal as a home remedy for COVID during pregnancy.
Note that if you are using Chlorine Dioxide Solution as a COVID cure during pregnancy, that NAC can cancel out the effects of Chlorine Dioxide Solution. However, anyone who is trying to treat COVID at home during pregnancy, should consider administering Chlorine Dioxide Solution during the daytime using the protocol at this link. At night, women can take up to 3 doses of NAC every 4 hours to improve respiration and detoxification during sleep. Try to separate the first dose of CDS from the last dose of NAC by at least 4 hours.
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NAC for Respiratory Infection During Pregnancy
If you catch a cold or the flu during pregnancy, NAC can be used not only to treat respiratory infection, but also makes it easier to breathe when the sinuses or bronchial tubes get blocked. NAC thins mucus which makes the mucus flow more easily out of infected sinuses. In a respiratory infection, thin, flowing mucus is a key to getting rid of infection. Mucus in the human body, after all, was designed to grab onto and carry infectious pathogens out of the body. When mucus clogs the sinuses and stops flowing, pathogens get trapped in the body. NAC keeps that mucus flowing smoothing, which means that it can naturally unblock sinuses and bronchial tubes during pregnancy without harming the growing fetus.As a natural treatment for respiratory infection during pregnancy, NAC is comparable to guaifenesin (an over-the-counter drug) in terms of its ability to unclog sinuses and get rid of chest congestion. But NAC isn’t toxic the way that guaifenesin is toxic to the body. Indeed, NAC is not only safe for use during pregnancy, it can actually protect the growing baby during pregnancy. The same thing cannot be said of guaifenesin.
Note that if you are using Chlorine Dioxide Solution as a treatment for respiratory infection during pregnancy, NAC can cancel out the effects of Chlorine Dioxide Solution. If you are trying to treat a respiratory infection at home during pregnancy, consider administering Chlorine Dioxide Solution during the daytime using the protocol at this link. At night, pregnant women can take up to 3 doses of NAC every 4 hours to improve respiration and detoxification during sleep. Aim to separate the final dose of NAC during the night from the first dose of CDS by at least 4 hours for best results.
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NAC: Natural Treatment for Sinus Infection During Pregnancy
NAC has the following relevant health effects on the body that can help you safely treat a sinus infection during pregnancy:- It is anti-inflammatory. NAC can reduce inflammation in the sinuses to make it easier for the immune system to naturally overcome a sinus infection during pregnancy.
- It is antiviral. NAC can kill pathogens living in the sinuses without harming the fetus or causing health issues in the mother.
- It is mucolytic. In other words, NAC thins mucus to allow the sinuses to clear naturally during pregnancy.
- It is detoxifying. NAC causes the body to produce glutathione, which is the primary substance used by the body to remove toxins. Sinus infection during pregnancy often involves a buildup of toxins in the sinuses that cause inflammation.
- NAC works like guaifenesin to clear the sinuses, but it does this work without harming the mother or the fetus.
Note that you can also use dimethylsulfoxide (DMSO) as a powerful home remedy for sinus infection during pregnancy AS LONG AS YOU ARE NOT TAKING ANY OTHER PRESCRIPTION OR OVER-THE-COUNTER MEDICATIONS. DMSO CAN STRENGTHEN THE EFFECTS OF PRESCRIPTION MEDICATIONS SO YOU SHOULD NEVER COMBINE THE USE OF DMSO WITH OTHER MEDICATIONS. You can combine the use of DMSO with NAC. Take NAC orally every 4 hours at 600 mg per dose (2400 mg total). DMSO, in contrast, can be applied externally, just inside the nostrils. Put 1 drop of 99.9% DMSO with 3 drops of filtered, clean water (for a 25% DMSO mix). Then, administer 1 drop of the 25% DMSO mixture just inside each nostril. Sniff the droplet up into the nose. It will sting a bit, particularly if you have an active infection. The sting will go away within about 30 seconds. Read more about DMSO here.
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NAC, vitamin E, and vitamin C: Headache Treatment During Pregnancy
Headaches during pregnancy are common and many women try to avoid taking drugs like ibuprofen, acetaminophen, and aspirin while gestating. One study showed that the combination of NAC, vitamin E, and vitamin C were able to reduce brain inflammation and oxidative stress to prevent migraine during pregnancy and also treat pregnancy headaches.Study participants included adults who experienced 2 to 8 migraines each month. Participants who received the NAC, vitamin E, and vitamin C treatment experienced, on average, 3 fewer migraine headaches per month as a result of treatment. The length of the migraine headaches was also reduced in those where given the NAC, vitamin E, and vitamin C treatments. If you suffer from migraines during pregnancy, home remedies like NAC can help you reduce the frequency, strength, and duration of the headaches.
NAC: Detoxification During Pregnancy
NAC is transformed into glutathione, the primary substance that our bodies use to remove toxins. Glutathione cannot be taken orally as a supplement because it breaks down too easily in the stomach before achieving the target tasks in the body. Though there are glutathione products on the market, there are a number of studies showing that these products aren’t able to achieve the same level of detoxification as NAC or L-Cysteine. And because NAC has been studied in terms of effectiveness at safely treating pregnancy-related health issues affecting both mother and infant, we also recommend the use of NAC for detoxification following exposure to pathogens, toxic mold, toxic chemicals, or toxic drugs.NAC, after all, has been used as an antidote against poisoning in emergency settings. It has particularly been used as an antidote against acetaminophen poisoning and amatoxin-containing mushroom poisoning.
NAC: Natural Depression Treatment During Pregnancy
As a detoxifying agent, NAC is able to reduce symptoms of depression safely during pregnancy. It works by removing ammonia-based toxins that irritate brain tissues. Through this mechanism of action, NAC is able to reduce the frequency and strength of toxic, nagging thoughts that can plague pregnant women with depression.NAC or L-Cysteine can be used as a natural home remedy for depression during pregnancy along with L-tyrosine and L-tryptophan, other amino acids that promote the production of dopamine and serotonin in the body. These amino acids are naturally present in foods like meats and milks, but some women need to supplement with L-tyrosine and L-tryptophan to ensure that they get enough of these aminos to build plenty of the necessary neurotransmitters that prevent depression. Taking L-tyrosine with L-tryptophan and a B-100 supplement (take 1 pill daily), magnesium glycinate (480-600 mg per day), zinc/copper (15 mg / 2 mg), vitamin D3/K2 (125 mcg / 90 mcg), and 50 mg of Lugol’s iodine 2% daily (20 drops on the skin or in drinking water) is recommended for best results. Additionally, Lithium Orotate is a natural salt that can safely be taken to treat depression naturally during pregnancy. Lithium Orotate is not the same as Lithium Chloride or Lithium Carbonate. While Lithium Chloride and Lithium Carbonate are unnatural, synthetic salts of lithium, Lithium Orotate is a natural lithium salt that’s present in many drinking water sources. Even tiny quantities of Lithium Orotate–microdoses–can prevent or cure depression during pregnancy. Start with 5 mg of Lithium Orotate twice daily in the morning and again in the evening.
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As a treatment for depression during pregnancy, start with a low dose of NAC at 600 mg up to twice daily (one in the morning and one in the evening) along with 1000-3000 mg of L-tyrosine in the morning and 1500 mg of L-tryptophan in the evening. Take 5 to 20 mg of Lithium Orotate twice daily (up to 40 mg) in divided doses along with the NAC, L-tyrosine, and L-tryptophan.
Note that it will take approximately 24 hours for you to notice the full effect of this natural depression treatment during pregnancy.
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NAC: Natural Anxiety Treatment During Pregnancy
Women who experience anxiety during pregnancy should consider taking NAC. NAC is a safe anxiety treatment during pregnancy that not only reduces the frequency and strength of anxiety-provoking thoughts, but it also reduces the likelihood that a woman will develop intraamniotic inflammation or infection during pregnancy.NAC can also be combined with L-tyrosine (1000-6000 mg per day), L-tryptophan (1500 mg evening dose), and Lithium Orotate (take 5-20 mg in the morning and again at night) for a stronger anti-anxiety treatment that’s safe during pregnancy. Note that this treatment takes about 24 hours to really take effect and most people need to take supportive nutrients to ensure that these nutrient substances work properly as a home remedy for anxiety. The supportive nutrients that you’ll need include:
- Vitamin B-100 Supplement - Take 1 pill daily
- Lugol’s iodine 2% - 50 mg or 20 drops per day in drinking water or applied to the skin
- Vitamin D3/K2 - 125 mcg / 90 mcg
- Zinc / Copper - 15 mg / 2 mg
- Magnesium Glycinate - 480-600 mg per day
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NAC: Natural Treatment for Postpartum Depression
Some of our clients with postpartum depression have had success combining NAC with an over-the-counter pharmaceutical known as “Methylene Blue”. Methylene Blue should not be taken during pregnancy and you should also avoid Methylene Blue if you’re trying to conceive. But, if you’ve recently given birth and you’re looking for a natural treatment for postpartum depression, consider combining NAC with Methylene Blue.Note that you should not take Methylene Blue if you are already taking a prescription anti-depressant medication. Wait for at least 2 weeks after taking the last dose of a prescription antidepressant before beginning to take Methylene Blue. Methylene Blue is a powerful MAOI that is available over-the-counter.
Note, however, that while Methylene Blue should be avoided during pregnancy and prior to conception, NAC improves fertility levels and it can be taken throughout pregnancy and during lactation. NAC promotes general detoxification of the body. In terms of mental health, NAC has been shown to reduce the frequency and strength of negative, nagging thoughts. It can be used to treat obsessive and compulsive behaviors, but it also helps reduce feelings of panic and anxiety. When used in combination with Methylene Blue, the effects of both NAC and Methylene Blue synergize.
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As an at-home treatment for postpartum depression, administer the correct Methylene Blue dose according to the patient’s body weight (see the link below) along with 4 daily doses of 600 mg of NAC every 3 to 4 hours of the day.
Read more about the dosing of Methylene Blue as a Natural Cure for Postpartum Depression here.
Consider combining NAC and Methylene Blue treatment with L-tyrosine (1000-6000 mg per day taken every 4 hours) and L-tryptophan (1500 mg evening dose) supplements as well as Lithium Orotate (start with 5 mg twice daily but take up to 50 mg twice daily or 100 mg total per day). The following supportive nutrients will help your body use the L-tyrosine and L-tryptophan efficiently. Indeed, many women who are seeking a natural home remedy for postpartum depression, are actually low on some of the supportive nutrients listed below, which is why their body is not properly processing the L-tyrosine and L-tryptophan present in the diet.
- Vitamin B-100 Supplement - Take 1 pill daily
- Lugol’s iodine 2% - 50 mg or 20 drops per day in drinking water or applied to the skin
- Vitamin D3/K2 - 125 mcg / 90 mcg
- Zinc / Copper - 15 mg / 2 mg
- Magnesium Glycinate - 480-600 mg per day
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Resources:
• Buhimschi, C. S. et al. (2019). Randomized controlled trial of n-acetylcysteine to prevent adverse neonatal outcome in pregnancies with intra-amniotic infection/inflammation. Retrieved March 3, 2022 from https://www.ajog.org/article/S0002-9378(18)31033-0/fulltext
• Amin, A. F. et al. (2008). N-acetyl cysteine for treatment of recurrent unexplained pregnancy loss. Retrieved February 2023 from https://pubmed.ncbi.nlm.nih.gov/18983759/
• Visser, E. J. et al. (2020). Reduction in Migraine and Headache Frequency and Intensity With Combined Antioxidant Prophylaxis (N-acetylcysteine, vitamin E, and vitamin C): A Randomized Sham-Controlled Pilot Study. Retrieved February 2023 from https://pubmed.ncbi.nlm.nih.gov/32306462/
• McNeil Consumer Healthcare Division (n.d.). Guidelines for the Management of Acetaminophen Overdose. Retrieved February 4, 2023 from https://www.tylenolprofessional.com/sites/tylenol_hcp_us/files/acetaminphen_overdose_treatment_info.pdf
• Shi, Z. et al. (2020). N-Acetylcysteine to Combat COVID-19: An Evidence Review. Retrieved February 4, 2023 from https://pubmed.ncbi.nlm.nih.gov/33177829/
• Zhou, N. et al. (2021). The Potential Mechanism of N-acetylcysteine in Treating COVID-19. Retrieved February 4, 2023 from https://pubmed.ncbi.nlm.nih.gov/33371832/
