Bisphosphonates are osteoporosis medications that don't offer any benefits in terms of bone health, but they are heavily correlated with serious health risks including an increased risk of developing dementia.What You Need to Know about Organophosphate Exposure via Bisphosphonate Medications
UPDATE 2023: Recently, we uncovered some research showing that Pueraria lobata and Pueraria mirifica are two plant medicines that can be helpful in treating osteoporosis and dementia. This herb is also used as an adjunct therapy for diabetes and mood disorders and it functions through several mechanisms of action to treat osteoporosis and dementia at the same time. Please click here to read about plant medicines that are being studied for the treatment of dementia and osteoporosis. Pay special attention to Trifolium pratense / Red Clover and the Pueraria plants as these are also some of the most powerful anti-cancer herbs on the planet as well.2nd UPDATE 2023: Recently, we found that in the scientific literature, there is a link between dementia and osteoporosis via Brain Derived Neurotrophic Factor (BDNF). This link has been described in studies into a natural substance known as 7,8-dihydroxyflavone. This substance has been studied in depth for its ability to regrow brain cells in patients with dementia. 7,8-dihydroxyflavone essentially mimics the effects of BDNF. But scientists were surprised to find that 7,8-dihydroxyflavone was also able to improve bone health because BDNF plays a role in producing strong bones. 7,8-dihydroxyflavone is available as a supplement that you can purchase online, but click here to read more about the benefits and dosing for 7,8-dihydroxyflavone here.
Osteoporosis, particularly post-menopausal osteoporosis, is conventionally treated with bisphosphonates, which are organophosphates that have been renamed so as not to alert patients to their inherent toxicity. Organophosphates are well-known for their ability to cause dementia and memory loss as well as Parkinson’s Disease symptoms (muscle tremors), but they are less famous for causing Intermediate Syndrome, a condition that mimics Myasthenia Gravis. The word “bisphosphonate” was certainly created/named in order to obscure the relationship between organophosphate poisoning and Myasthenia Gravis in patients who don’t recognize their symptoms as such.
Organophosphates have a broad spectrum of action on the human body. They build up in the body over time, which is why Big Pharma decided to use them as drugs (bisphosphonates). Organophosphates, after all, are fairly well-known not just as insecticides, but also as nerve agents that can be deadly at high-doses via their impact on the nervous system. Indeed, their impact on the nervous system of insects is their claim to fame. The fact that they also happen to impact the human nervous system doesn’t really matter as long as these chemicals sell and make a lot of money for Big Ag (which is an off-shoot of Big Food and Big Pharma).
Organophosphates, which are referred to as “bisphosphonates”, are prescribed to patients with osteoporosis and other bone diseases because they contain phosphates, which are supposed to help increase bone density and strength. At least that’s the idea. That’s the propaganda that sells these drugs. But though lots of studies have been funded by Big Pharma to prove the “value” of these drugs, there is literally no scientific evidence showing that bisphosphonates prevent bone fractures in osteoporosis patients–or in anyone. There is, however, compelling evidence that exposure to bisphosphonates can lead to bone fractures of a particular type and a weakening of bone tissues as well as the death of bone tissue, particularly in the jaw as a result of the fact that the phosphates that are incorporated into bone tissues of bisphosphonate patients do not line up with calcium in the healthy, crystalline pattern that happens when people have healthy, balanced levels of phosphates and calcium in their diets and in the environment. That crystalline pattern that’s so crucial for strong bones and teeth is something that only happens when calcium ions and inorganic phosphates come into contact in the right context. Bisphosphonates, sadly, are organic phosphates. They contain chemical elements that should not be associated with phosphate ions anywhere in the bone tissues. And this crucial chemical difference is what makes bisphosphonates harmful to bone health and also a contributing factor in the development of dementia.
Bisphosphonates are excreted by the kidneys and like organophosphates, bisphosphonates damage the kidneys and cause chronic kidney disease or kidney failure. Chronic kidney disease is strongly correlated with a heightened risk of dementia which is not a coincidence. Damage to the kidneys by organophosphate exposure and bisphosphonates can stay at subclinical levels for many years before it becomes detectable as observable dementia symptoms.
Bisphosphonate exposure gives us a strong link between dementia and osteoporosis via the kidney damage that they cause, but it’s the fact that bisphosphonates belong in the category of “organophosphates” that really highlights the reason why dementia and osteoporosis are related when osteoporosis patients have received bisphosphonate treatments. Organophosphates (including not only organophosphate pesticides, but also bisphosphonates), by their very nature, were designed to interact with the nervous system, especially acetylcholine, which is one of the neurotransmitters that is most often implicated in Parkinson’s Disease, Alzheimer’s Disease, Vascular Dementia (via its effects on the blood supply to the brain through the phosphate-calcium imbalances caused by organophosphates that you can read more about here), Lewy Body Dementia, and more. Also note that key experts on dementia have asserted all dementia is a form of vascular dementia, meaning that the root cause of all dementia cases originates in the blood vessels.
If this is true about dementia, then the osteoporosis-atherosclerosis connection becomes even more important in solving the riddle of the dementia and osteoporosis connection. Atherosclerosis, a condition characterized by the presence of calcium deposits in the blood vessels that restrict blood flow to the brain, has been known to cause vascular dementia. And, atherosclerosis and osteoporosis are essentially caused by the same nutrient deficiency (vitamin K2) that is virtually unknown in the developed world. Supplementation with this nutrient can reverse or dramatically improve the symptoms of patients with either of these conditions (in which case, it stands to reason that dementia patients may also suffer from the same vitamin K2 deficiency, and would benefit from supplementation with this nutrient). Read more here about vitamin K2 as a cure for atherosclerosis-osteoporosis. For a more in-depth discussion of how vitamin K2 works and why organophosphates and phosphate food additives as well as bisphosphonate drugs can cause dementia through calcium-phosphate imbalances in the body click here.
Dementia after Osteoporosis: What’s the Connection?
A patient with osteoporosis has a 1.2 to 1.3 fold increased risk of developing dementia in both men and women according to the Journal of Alzheimer’s Disease. And studies have shown that people who have taken bisphosphonates over long periods of time (longer than one year) are at an increased risk of developing Alzheimer’s disease and other forms of dementia. So that’s pretty compelling since bisphosphonates are the gold-standard in terms of osteoporosis treatment in conventional medicine.Bisphosphonates / Medications That Contain Organophosphates
Rather than referring to organophosphate-containing medications as “organophosphates”, Big Pharma contrived a new word to hide the fact that these medicines are, at their core, organophosphates. The word that they chose to label organophosphate medications is “bisphosphonates”.Bisphosphonates are medications that contain organophosphates. If you or a loved one is taking a bisphosphonate medication, you should know that these drugs have a reputation for causing the jaw bone to die (osteonecrosis of the jaw) following a dental procedure though sometimes jaw bone necrosis happens spontaneously. Osteonecrosis of the jaw can easily result in death and let me tell you, it seriously impacts quality of life.
Nonetheless, bisphosphonates are the most regularly prescribed drug used to treat osteoporosis and other bone-related diseases by conventional medicine doctors. Indeed, bisphosphonates are the most highly recommended treatment for post-menopausal osteoporosis in women.
The Truth about Bone Remodeling and Remineralization
In normal, healthy people, bone tissues as well as teeth are constantly breaking down and then rebuilding themselves. This process of dynamic destruction and rebuilding is kept in balance by osteoblasts (which create bone) and osteoclasts (which destroy bone). The bisphosphonates inhibit bone remodeling by killing osteoclasts, thus slowing bone loss (or so the scientific studies say). Doctors tell their patients that this reduction in osteoclast-bone-cell-murderers will fix the problem of low bone density. Patients are never educated about vitamin K2 because doctors know nothing of nutrition, especially cutting edge discoveries like vitamin K2, the bone remineralizing vitamin–the vitamin that moves calcium out of arteries and blood vessels into the bones and teeth where it belongs. Read more about how to cure osteoporosis with vitamin K2.
Indeed, osteoclasts do not “murder” bone cells. Rather, they maintain an ecological-sort of balance in bones to make sure that bones exist as dynamic, every-changing structures that are flexible, but strong.
If we think of an airplane and how a structure like an airplane must be strong and relatively light-weight, yet flexible, this will give us a good model for bone tissues. Like the structure of airplane, our bones must be able to withstand quite a lot of turbulence. In order to that, they must be flexible structures, not rigid. Skyscrapers are another good example of how flexibility is a form of strength. At the top of a skyscraper you can feel the movement and the dynamic swaying that occurs to keep the skyscraper standing and intact. Our bones are designed to be strong and yet flexible as structures that are made of crystals containing calcium ions (positively charged) and phosphate ions (negatively charged). These ions link together similar to the way that the positive and negative poles of two magnets would be attracted to each other. In bones, calcium and phosphate ions are attracted to each other like magnets and they can release their grip on each other, as needed to “remodel” bone tissues that are experiencing new or different kinds of stressors. It’s an amazing process that shouldn’t be “fiddled with” by doctors using something as toxic as bisphosphonates.
Nonetheless, bisphosphonates are used most commonly in the treatment of the following diseases:
- Osteoporosis
- Osteitis Deformans / Paget’s Disease of the Bone
- Bone Cancer
- Multiple Myeloma
- Breast Cancer
- Prostate Cancer
- Other Types of Cancer
- Osteogenesis Imperfecta
- Primary Hyperparathyroidism
- Fibrous Dysplasia
- Other conditions involving fragile bones
- Complex Regional Pain Syndrome
Bisphosphonates are also used to diagnose certain bone diseases, which means that you can be exposed to organophosphates on a doctor visit to simply diagnose whether or not you have a bone disease. So make inquiries into the substances your doctor may be using to diagnose bone diseases too. Organophosphates lodge themselves in bone tissues and they build up in an unnatural way that makes bones unnaturally rigid instead of flexible (as they’re meant to be).
Bisphosphonates and Other Drugs That Contain Organophosphates
Below is a list of some of the organophosphate medications that can cause organophosphate poisoning:
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- Malathion - A parasympathomimetic that is used to treat head lice.
- Echothiophate - An acetylcholinesterase inhibitor that is used in eye medications to increase the drainage of intraocular fluid. It is most commonly used to treat glaucoma.
- Amifostine - Amifostine is use to protect kidney cells and renal toxicity during cancer radiation treatment. It is used to prevent patients from having an excessively dry mouth (xerostomia).
- Farnesyl thiopyrophosphate -
- Farnesyl diphosphate - Used in the treatment of osteoporosis.
- Geranylgeranyl diphosphate -
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- Coumaphos - Used to kill ticks, mites, flies, and fleas in farm animals.
- Dichlorvos - Dichlorvos is an organophosphate used indoors to control pests that might invade foods that are in storage.
- Famphur - Famphur is used to control grubs and lice in cattle and pigs.
- Fenthion - Fenthion is an organophosphate drug that is used to kill insects, birds, and mites. It is a cholinesterase inhibitor.
Bisphosphonate Adverse Effects and Side Effects
Bisphosphonate side effects and adverse effects can give us insight into how organophosphates in the environment affect humans. A number of musculoskeletal issues are associated with bisphosphonate administration. As such, one might presume that musculoskeletal issues are associated with organophosphate exposure too. Severe joint pain, bone pain, and muscle pain have all been correlated with bisphosphonate administration.Bisphosphonate exposure is also strongly correlated with an increased risk of developing atrial fibrillation particularly when bisphosphonates are administered intravenously, but again, one might also conclude that long-term, chronic exposure to organophosphates in the environment would also cause an increased risk of atrial fibrillation.
Women who take bisphosphonates to treat osteoporosis often experience unusual fractures known as “bisphosphonate fractures” of the thigh bone. Scientists and doctors who are aware of the toxic naturaeof taking bisphosphonates for osteoporosis say that bisphosphonate exposure leads to an over-suppression of bone tissue turnover by interfering with the natural dynamic of bone destruction and bone rebuilding. Micro-cracks in the bone tissue may not be able to heal properly or they may heal poorly as a result of bisphosphonate administration. The crystalline pattern of healthy bone tissues are disrupted by bisphosphonates and also organophosphates in the body.
If you have osteoporosis or heart disease or both, consider taking vitamin K2 with vitamin D as a bisphosphonate alternative and as a cure for osteoporosis as well as atherosclerosis.
Oral Bisphosphonates
Oral bisphosphonates cause stomach upset and inflammation. Some doctors believe that oral bisphosphonates significantly increase the risk of esophageal cancer as well. Big Pharma has worked hard to cover-up the studies demonstrating the increased risk of esophageal cancer, but patients who have taken bisphosphonate medication should download our four-volume Cancer Cure Catalog series (the first volume is free) to work with powerful, but natural cancer-prevention agents.
Intravenous Bisphosphonates
Intravenous bisphosphonates can cause flu-like symptoms with fever after the first infusion. Some experts believe this is due to T-cell activation. When administered for the treatment of cancer, bisphosphonates have been heavily associated with osteonecrosis of the jaw (including both the mandible (the lower jaw) and the maxilla (the upper jaw). Osteonecrosis of the jaw caused by bisphosphonates may occur spontaneously (40% of cases) or it may be spurred by a dental procedure (60% of cases).If you are suffering from cancer and you would like to learn more about alternative treatments for cancer using medications that won’t cause your jaw bone to die, download our four-volume Cancer Cure Catalog series (the first volume is free).
Bisphosphonates and Dementia
Organophosphates cause nervous system damage and bisphosphonates are organophosphates. Nervous system damage happens as a result of calcium imbalances that, in turn, are caused by a high phosphate load in the body. Phosphate levels are meant to be dynamic. Phosphate is an important ion in the body that’s supposed to come and go according to what our bodies need. Organophosphates build up in the body in an unnatural way though. And this has a negative effect on all organ systems, especially the nervous system, but also the bones, and the kidneys.When I worked in long-term care many years ago, patients would often develop dementia suddenly due to a kidney or bladder infection. So the relationship between kidney damage and dementia due to bisphosphonate exposure is important. But though kidney damage due to bisphosphonate exposure as a treatment for osteoporosis and dementia symptoms reflecting kidney problems is compelling and worth exploring in greater detail, the direct effect of organophosphates on the human nervous system is even more compelling in terms of the relationship between osteoporosis and dementia.
A number of people have anecdotally reported an observed relationship between the administration of Fosamax and dementia. Fosamax is a popular bisphosphonate drug that doctors have prescribed en masse to post-menopausal women.
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Antidotes to Organophosphate Poisoning / Bisphosphonate Poisoning
Though we’ve already uncovered some probiotics and herbal treatments for organophosphate poisoning (including bisphosphonate poisoning), this is an ongoing project and we have several leads that we’re still researching and developing. Vitamin K2 is an important nutrient antidote to organophosphate exposure, though we aren’t yet sure how it would function in regard to organophosphates in the body. This nutrient, though, is perhaps the most important nutrient that you can work with as a natural organophosphate poisoning treatment. Without vitamin K2 (which is not usually present in the diet of most people living in developing countries), you will have hard time restoring your health. But stay tuned to AlivenHealthy as we’ll be posting information about natural organophosphate poisoning treatments as we find them in the upcoming weeks and months.
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We've recently released the Living Database, the tool that Lydian and I use to store our data when we research cures for diseases. Sometimes we stumble across natural treatments cures for rare diseases in the scientific literature. If we do, we put in the Living Database. Sometimes we find links to surprising scientific data or even anecdotal reports of a cure for diseases that have been dubbed "incurable" or even, in some cases "untreatable" by doctors. And this tool, the AlivenHealthy Living Database allows us to store this information. Now, we've made the database live so our readers can use it to find cures for disease even if we haven't had a chance to write about it yet. The AlivenHealthy Living Database is an excellent tool for healers and body workers or even just for average people to use on family and friends. If you search for a disease or disorder that isn't in our database, this alerts Lydi and I to the fact that someone in the database user pool is looking for that particular disease. If our client load is low and we have time to do research into that disease, we can update the database immediately with information about diseases that interest Living Database users. Click here to learn more and download the Living Database now.Resources:
• Lyndon, E. J. (2018). Osteoporosis linked to higher risk for dementia. Retrieved October 2, 2022 from https://www.healio.com/news/rheumatology/20180906/osteoporosis-linked-to-higher-risk-for-dementia#:~:text=and%20December%202012.-,Osteoporosis%20is%20associated%20with%20a%201.3%2Dfold%20increase%20in%20the,among%20women%2C%20according%20to%20findings.&text=The%20study%20also%20included%2029%2C983,%2C%20comorbidities%20and%20co%2Dtherapies.
• Tiihonen, M. et al. (2016). Incidence and Duration of Cumulative Bisphosphonate Use among Community-Dwelling Persons with or without Alzheimer’s Disease. Retrieved October 2, 2022 from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927880/
• Black, D. M. et al. (2022). Bisphosphonates and the risk fo atypical femur fractures. Retrieved October 2, 2022 from https://pubmed.ncbi.nlm.nih.gov/34920168/
• Rroji, M. et al. (2022). Phosphate in the Context of Cognitive Impairment and Other Neurological Disorders Occurrence in Chronic Kidney Disease. Retrieved October 2, 2022 from https://pubmed.ncbi.nlm.nih.gov/35806367/
• Peacock, M. (2020). Phosphate Metabolism in Health and Disease. Retrieved October 2, 2022 from https://pubmed.ncbi.nlm.nih.gov/32266417/
• Miller, P. D. (2007). Is There a Role for Bisphosphonates in Chronic Kidney Disease? Retrieved October 2, 2022 from https://onlinelibrary.wiley.com/doi/10.1111/j.1525-139X.2007.00271.x
• Bone Health and Osteoporosis Foundation (n.d.). Side Effects of Bisphosphonates (Alendronate, Ibandronate, Risedronate, and Zoledronic Acid). Retrieved October 2, 2022 from https://www.bonehealthandosteoporosis.org/patients/treatment/medicationadherence/side-effects-of-bisphosphonates-alendronate-ibandronate-risedronate-and-zoledronic-acid/
