Though bisphosphonates are often prescribed to increase bone density, they don't reduce bone fractures and in fact, bisphosphonate exposure is associated with a certain type of bone fracture in the femur and the death of bone tissues in the jaw.Bisphosphonates: Negative Health Effects and Mechanisms of Action
Bisphosphonates are prescribed to treat the following diseases and disorders:- Osteoporosis
- Osteomalacia
- Osteosclerosis
- Complex Regional Pain Syndrome (CRPS)
- Paget disease
- Fibrous dysplasia
- Bone cancers
- Multiple myeloma
- Leukemia
All organophosphates contain both carbon and phosphorus which is why they are organic phosphates. The only healthy phosphates for human consumption are inorganic phosphates, however, that do not contain carbon.
Bisphosphonates are classified as pharmaceutical drugs but they are also technically organophosphates because they contain both carbon and phosphorus. According to the CDC, all organophosphates cause predictable health effects that are negative. Bisphosphonates, because they are “medicines”, are able to list these negative health effects as “side effects” or “adverse events” to confuse and mislead patients.
Bisphosphonate side effects include:
- Bone pain (due to the unhealthy effects of the bisphosphonates on bone remodeling)
- Joint pain / Arthritis
- Muscle pain
- Nausea
- Heartburn
- Difficulty swallowing
- Esophageal irritation
- Stomach ulcers
- Low calcium levels (which can cause low bone density)
- Flu-like symptoms
- Fever
- Headache
- Eye inflammation (uveitis)
- Kidney failure
- Kidney disease
- Osteonecrosis of the jaw / Death of jaw tissue (which is quite common, often deadly, and extremely painful)
- Frequent Bone fractures (the risk of “atypical femoral fracture” increase the longer patients take bisphosphonates)
- Heart problems
- Abnormal bone growth and sclerotic bands in the metaphyses in children taking bisphosphonates
- Hyperlipidemia
Bisphosphonates are pyrophosphate / diphosphate analogs. Pyrophosphate is the type of phosphate found naturally in ATP and in DNA. Bisphosphonates differ from pyrophosphate in that the phosphorus in bisphosphonate drugs is connected to a carbon “bridge” rather than to an oxygen “bridge” as in pyrophosphate. In other words, the natural, healthy form of pyrophosphate that our bodies need in order to produce normal DNA and cellular energy contains phosphorus and oxygen atoms, not carbon-containing atoms. Bisphosphonates contain phosphorus, oxygen, and carbon atoms. It is the presence of carbon with oxygen and phosphorus that leads to unnatural results, negative side effects, and adverse events due to bisphosphonate use.
Bisphosphonates are drugs that are typically prescribed for osteoporosis or other bone diseases or even bone and blood cancers like leukemia (meanwhile, however, these same drugs have actually been proven to be able to cause these diseases in the first place and aggravate them when they’re already present). Bisphosphonates like Zolendronate are also prescribed to treat Complex Regional Pain Syndrome (CRPS), a disorder of the nervous system though too.
Big Pharma spends billions and trillions of dollars to develop synthetic forms of natural nutrients like phosphorus / phosphate and other substances to produce drugs that meet the following requirements:
- The drugs must be patentable and thus profitable. You cannot patent a natural substance because natural substances are and should be available to everyone. Thus, you can’t get rich from selling natural substances. So Big Pharma must patent their drugs / treatments or else they won’t make enough money to sustain themselves.
- The drugs must not cure disease. Curing diseases means fewer patients and fewer profits, so the ideal drug / treatment is one that will ensure that patients become ever more dependent on the healthcare system. A cure for disease sets people free.
Organic phosphorus / phosphate (organophosphate) is most potent and most toxic if the body is deficient in vitamin K2 and iodine. We expand on this topic in detail here. Bisphosphonates are pyrophosphate analogs, which means that they mimic the action of natural, healthy pyrophosphate in the human body. Essentially, bisphosphonates trick the body into thinking that the phosphates they contain are the real thing. Bisphosphonates, as pyrophosphate analogs, and they have a diversity of different carbon side chains that allow these compounds to be reconfigured by Big Pharma to produce second, third, and fourth generation drugs. This ensures that doctors perpetually have bisphosphonate drugs to prescribe that are under patent law, maintaining the bloated profitability of these drugs, even as older-generation bisphosphonate drugs eventually outlive their patents. Contrary to popular belief, the youngest generation of a drug is often the most toxic, having undergone numerous changes that are all designed to keep it under patent law, not to make it better or healthier or more effective as a treatment for patients. Older generations of drugs tend to be more effective and less toxic. They are also cheaper, less prescribed by doctors, and less profitable to Big Pharma.
Bisphosphonates may be prescribed for bone diseases like osteoporosis, Paget’s disease, and bone cancers but the actual mechanism of action behind how these drugs work is said to be “not well understood” according to scientific literature. Or at any rate, funding is not available to demonstrate that toxic bisphosphonates pretend to be healthy, natural phosphate groups in bone tissues. Big Pharma has allocated funding to scientists wishing to prove that bisphosphonates inhibit bone destruction and resorption, however.
Scientists have also shown that the bisphosphonates bind to bone tissues, but there are many reports of unusual, low-impact bone fractures of the thigh in patients who are taking bisphosphonates such as alendronate / Fosamax for several years as a treatment for osteoporosis or for osteopenia. These unusual fractures often occur after the patient experiences pain in the affected thigh before the fracture occurs and despite having a normal appearance on x-ray, these patients often experience a significant delay in bone healing. So, while bisphosphonates may seem to increase bone density in patients, some scientists have speculated that oversuppression of bone tissue turnover actually causes the bones to become brittle and prone to fracture.
So while your doctor may recommend bisphosphonates to increase the density or strength of your bone tissues, the fact remains that bisphosphonates do not prevent the bones from breaking. In fact, bisphosphonates increase the likelihood of bone fractures and they increase the time it takes for bone fractures to heal. This makes sense because the presence of a carbon atom in these pyrophosphate analogs would disrupt the natural phosphate-calcium crystalline shape that is necessary for strong bones and teeth.
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Vitamin K2 as a Cure for Leukemia, Osteoporosis, and More: An Antidote to Organophosphate Exposure?
Sadly, vitamin K2 is a cure for osteoporosis as well as leukemia and the various other diseases for which bisphosphonates are often prescribed. While we haven’t yet found research documenting the possibility that vitamin K2 can prevent damage due to organophosphate exposure through its ability to strengthen and heal bone tissues, we have found scientific evidence that vitamin K2 prevents bone tissue degradation due to prescription steroid use. Read more about vitamin K2 as a cure for lymphoma, leukemia, and other blood and bone cancers here. Read more here. about the dangers of supplementing with vitamin D without also supplementing with vitamin K2 at the same time. Read more here about government-sponsored deficiencies like vitamin K2 that deliberately deprive populations of people from the nutrients that would need to prevent diseases like COVID or osteoporosis and making those people vulnerable to organophosphate exposure.
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Osteonecrosis of the Jaw: Bisphosphonates
Jaw bone death or osteonecrosis is a problem that doctors have identified as a side effect of taking bisphosphonates. Death of bone tissue in the jaw occurs as a result of a lack of blood supply to jaw bone tissues. Osteonecrosis of the jaw is defined as exposed bone in the maxillofacial region that does not heal within 8 weeks of being identified by a healthcare provider in a patient who has been on bisphosphonates and who does not have a history of radiation therapy in the facial region.Jaw bone death or osteonecrosis is a problem that doctors have identified as a side effect of taking bisphosphonates. Death of bone tissue in the jaw occurs as a result of a lack of blood supply. Osteonecrosis of the jaw is defined as exposed bone in the maxillofacial region that does not heal within 8 weeks of being identified by a healthcare provider in a patient who has been on bisphosphonates and who does not have a history of radiation therapy in the facial region.
Bisphosphonates impair bone resorption and the formation of new bone tissues. As a result, old bone cells survive an unnaturally long-lifespan well-beyond what’s normal, but the network of blood vessels feeding these bone tissues are not maintained which means that bone tissues are still alive, but they receive no oxygen, food, or waste removal services. In the jaw bone, not having blood vessels can lead to bone tissue death which can then be complicated by infection. Slow wound healing and an inability to close the skin tissues that lead into the mouth ultimately cause the bone tissues to become infected and die.
The jaw bones have a higher bone resorption and remodeling rate than other bones in the body which is likely why they are the most prone to dying as a result of bisphosphonate use.
Cholesterol Biosynthesis and Bisphosphonates
Enzymes in the cholesterol biosynthesis pathway are inhibited by bisphosphonates which leads to reproductive hormone imbalance.Tyrosine Phosphatases and Bisphosphonates
Tyrosine phosphatases are inhibited by bisphosphonates. Tyrosine phosphatases are a group of enzymes that remove phosphate molecules from phosphorylated tyrosine residues found on proteins. Maintaining balanced levels of protein tyrosine phosphorylation is important for a number of cell functions to occur. In other words, bisphosphonates inhibit certain cellular functions to the detriment of human health.Bisphosphonates and Depression Plus the Link between Osteoporosis and Dementia
A number of patients have reported depression while taking bisphosphonates. Bisphosphonates can cause hypocalcemia or low calcium levels. Other patients have noted the uncanny relationship between osteoporosis and dementia, but most of these patients never consider the possibility that the osteoporosis prescription drugs that patients take might cause dementia years after treatment ends. Read more about this relationship between osteoporosis and dementia here. Chronic, low levels of calcium caused by bisphosphonate exposure are associated with the following symptoms:- Depression
- Tingling sensation / numbness
- Breathlessness
- Heart palpitations
- Muscle spasms
- Fatigue
- Memory loss
- Dementia symptoms
- Confusion
- Irritability
- Delusions
- Hallucinations
- More...
Summary
Organophosphate exposure can occur in the environment, but patients are also exposed to these toxins through organophosphate drugs known as bisphosphonates. Bisphosphonates cause a number of adverse health effects. Of particular note is the fact that while bisphosphonates are often prescribed to increase bone density in osteoporosis sufferers, but bisphosphonates actually increase the incidence and likelihood that a patient will experience a bone fracture because of their toxic effects on human physiology. Essentially, bisphosphonates hijack the natural calcium-phosphorus relationship in the body. To learn more about how to naturally remineralize the bone tissues and teeth to cure osteoporosis using essential nutrients, click here.
Root Cause: Common Environmental Toxins and How to Protect Yourself From Them - BUY HERE!
Resources:
• Goyal, Rajeev and Jialal, Ishwarlal (2022). Hyperphosphatemia. Retrieved October 4, 2022 from: https://pubmed.ncbi.nlm.nih.gov/31869067/
• Higdon, Jane (2014). Phosphorus. Retrieved October 4, 2022 from: https://lpi.oregonstate.edu/mic/minerals/phosphorus
• Harvard T.H. Chan School of Public Health (2022). Phosphorus. Retrieved October 4, 2022 from: https://www.hsph.harvard.edu/nutritionsource/phosphorus/#:~:text=Phosphorus%20is%20a%20mineral%20that,pH%20within%20a%20normal%20range.
• Wikipedia (2022). Hyperphosphatemia. Retrieved October 4, 2022 from: https://en.wikipedia.org/wiki/Hyperphosphatemia#:~:text=Hyperphosphatemia%20is%20an%20electrolyte%20disorder,can%20result%20in%20muscle%20spasms.
• Shafi, Nadeem (2017). Disorders of Phosphorus: Hyperphosphatemia and Hypophosphatemia. Retrieved October 4, 2022 from: https://www.cancertherapyadvisor.com/home/decision-support-in-medicine/pediatrics/disorders-of-phosphorus-hyperphosphatemia-and-hypophosphatemia/
• Wikipedia (2022). Phosphorus. Retrieved October 4, 2022 from: https://en.wikipedia.org/wiki/Phosphorus#Biological_role
• Orenda Technologies (n.d). Different Types of Phosphates. Retrieved October 4, 2022 from: https://blog.orendatech.com/different-phosphates
• Ritz, Eberhard, et. al. (2012). Phosphate Additives in Food - a Health Risk. Retrieved October 4, 2022 from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278747/
• De Bellefonds, Colleen (2019). What to Know About Phosphates, the Food Additive That’s in (Almost) Everything You Eat. Retrieved October 8, 2022 from: https://www.wellandgood.com/what-are-phosphates-in-food/
• Brissette, Christy (2017). Why phosphate additives will be the next taboo ingredient. Retrieved October 8, 2022 from: https://www.washingtonpost.com/lifestyle/wellness/why-phosphate-additives-will-be-the-next-taboo-ingredient/2017/03/29/7dd3247a-02cf-11e7-b1e9-a05d3c21f7cf_story.html
