Vitamin K2 with the Vitamin D: Two Vitamins That Work Together

Disclaimer: Consult with a doctor before deciding on a treatment plan for any disease.

Most people don’t realize it, but when taken by itself, vitamin D (which includes vitamin D3 or vitamin D2) can cause calcification of soft tissues throughout the body (such as calcium buildup in the arteries or calcium deposits in the kidneys or bladder). Vitamin D causes calcium to be absorbed but then, rather than depositing it in either the bones and teeth, vitamin D by itself puts calcium into the soft tissues. Without vitamin K2, vitamin D will direct the calcium into soft tissues. The vitamin K2 is necessary to ensure that calcium in the diet or supplements end up in the bones and teeth, and NOT in the soft tissues of the body. Magnesium is also important for these nutrients to all be able to work together and do their jobs correctly. 


Soft tissue calcification can lead to a wide variety of different health problems ranging from diabetes (which can be caused by pancreatic calcification) to atherosclerosis. Theoretically, just about any organ in the body can become partially or totally “calcified” as a result of supplementing with vitamin D without a balance of vitamin K2 administered in the proper proportion.

To avoid the problem of calcification, you should be taking 100mcg of vitamin K2 for every 125mcg/5000IU of vitamin D3 that you take. And, in fact, these two should ideally be taken in a supplement that combines the two together if possible. Choose a supplement that contains the MK-7 type of vitamin K2 (this is the most bioavailable kind), and whenever possible, eat grass-fed meats and other animal products since these contain vitamin K2 as well (non-grass-fed meats do NOT contain it, though). 


Examples of organs that can become calcified and the diseases/symptoms that might result include the following (this is NOT an exhaustive list):


  • Bladder calcification
  • Kidney calcification
    • Kidney disease
  • Liver calcification
  • Pancreatic calcification
    • Diabetes
    • Cancer
    • Persistent infection

Vitamin D Toxicity: When is it too much?

The main symptoms of vitamin D toxicity are: 

  • Calcium buildup in the blood vessels (hypercalcemia)
    • Nausea
    • Vomiting
    • Weakness
    • Frequent urination
  • Bone pain
  • Kidney problems
  • Calcium stone formation

Vitamin D toxicity can develop when a dose of 60,000IU or more of vitamin D is administered daily for a few months. The RDA is only 600IU of vitamin D per day. In reality, besides taking a K2+D3 supplement, there are only rare situations where a person would want to supplement with even more additional vitamin D. If you get enough sun and take a K2+D3 supplement, you’re likely to get all of the vitamin D that you need.


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Vitamin D3 and Vitamin K2 Deficiencies: Nutrition and Lupus

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Vitamin K2 and Vitamin D3 for Bone Remineralization and Cardiovascular Health: Cure Osteoporosis and Arteriosclerosis 

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