Cardiovascular Effects / Antihypertensive / Blood Pressure Lowering Effects
If you’re new to the idea of healthcare propaganda, let me expand on this idea briefly. When there’s a plant or a natural substance that’s widely available to people that’s known to cure a major disease, Big Pharma is always there, trying to create a synthetic molecule that mimics its effects such that they can produce a patentable drug that makes a lot of money. This is tricky because Big Pharma also presents itself as an altruistic savior-like resource in terms of health and medicine. In order to research an herb or a natural substance intensively for the sake of copying its effects while simultaneously keeping the herb’s positive medicinal benefits hidden from the public, certain valuable medicinal actions that the herb has may need to be “managed” using so-called “scientific studies” that are actually just true stories about the herb that have been “spun” to achieve a very specific political goal. If you are not well-versed in medical terminology or science, these “studies” may be your stopping block.
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So now that we’ve addressed this issue, let’s talk a bit about the cardiovascular effects of kratom.The mitragynine in kratom has shown calcium channel blocking activity and the ability to modestly lower blood pressure in animal models of high blood pressure. When it is used properly, by itself, kratom is quite safe in terms of its cardiovascular effects. It does have cardiovascular effects, but these medicinal effects are not negative except in certain specific contexts. The thing is, one of the ways in which the valuable medicinal effects of kratom is obscured is by talking about “deaths associated with kratom”. These deaths, are noted in the scientific literature without highlighting and really emphasizing the fact that the kratom was being used with another substance.
Scientists who are studying kratom have noticed this trend and every now and then, in the literature, you’ll find a scientific review that pays special note to the fact that kratom is a valuable plant medicine and we shouldn’t ignore it just because there are deaths associated with drug-interactions. This scientific article makes special mention of the lack of scientific data saying that kratom is dangerous or deadly when it is used properly by itself. We might say that Big Pharma is “pharming” kratom by funding plenty of scientific articles, that are written by faithful underlings to ensure that this herb is regarded as “too dangerous”. Meanwhile, part of the “pharming” process involves intensive laboratory studies to find molecules that are similar to the natural substances found in the plant, but that fulfill very specific requirements:
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- These molecules cannot exist in nature. As long as they don’t exist in nature, the synthetic molecule that mimics the kratom-based molecule will be patentable and therefore potentially profitable.
- The molecules absolutely must NOT cure a disease. Curing disease is not profitable. Covering up symptoms is profitable. So, if the molecule accidentally cures a disease in the studies involved in gaining approval for its use, it will be “shelved” such that doctors are not allowed to prescribe it unless they administer every other potential drug that’s available first (patients are often too sick to recover after being given all of the non-healing drugs).
This is just one technique that’s used to keep cancer cures hidden.
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One narrative review of all scientific literature regarding kratom / Mitragyna speciosa and negative cardiovascular effects noted that mitragynine, the main alkaloid that’s found in kratom can cause prolonged QTc intervals and an increased risk of torsades de pointes when the mitragynine is administered by itself. As a whole plant though, Mitragyna speciosa / kratom does not seem to produce this type of cardiac risk wherein torsades de pointes could occur.This narrative review later said that there was one study that showed that kratom as a whole herb could increase QTc intervals in a dose-dependent manner.
But then, there are the case reports that show that kratom consumption is sometimes associated with ventricular arrhythmia and cardiopulmonary arrest. That sounds scary, right? But the author of the narrative review pointed out that these case studies involved kratom plus another drug. As such, it isn’t fair or even intelligent to say that kratom is responsible for causing cardiopulmonary arrest if another drug is involved. Drug interactions are always a problem that have to be managed and considered in medicine.
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The authors of the narrative review that looked closely at cardiovascular effects with kratom use were able to see that the use of other substances with kratom can be deadly or harmful and unresolved, underlying cardiovascular illness can also be a problem for those who are using kratom at high doses.In order to present a balanced perspective on this issue, sadly, we have to present an imbalanced perspective to counteract the propaganda out there about kratom. Big Pharma has an unfair advantage in presenting herbs in a manner that suits their profit-interests. But tes, it’s true that you have to exercise caution with kratom and pay attention to dosing, cycling through the vein colors, and how your body is responding to treatment with this herb. You have to use critical thinking to decide what’s best for your body. It’s unwise to combine kratom with other things without giving thought and attention to the problem of drug interactions.
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All medicine can be poison when given at the wrong dose. And all medicine can be inert if given at the wrong dose too. Dosing matters. All medicines have the potential to interact with other medicines that you’re taking and these interactions might be valuable and beneficial or they might be harmful, if not deadly.At the proper dose and with proper use, kratom is a blood-pressure-lowering herb. It can be used intentionally to lower blood pressure, but it would be unwise to combine it with other blood-pressure-lowering drugs.
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Resources:
• Bin Abdullah, M. F. I. L. et al. (2021). The Adverse Cardiovascular Effects and Cardiotoxicity of Kratom (Mitragyna speciosa Korth.): A Comprehensive Review. Retrieved June 4, 2026 from https://pmc.ncbi.nlm.nih.gov/articles/PMC8504575/
Swogger, M. T. et al. (2022). Understanding Kratom Use: A Guide for Healthcare Providers. Retrieved June 4, 2026 from https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.801855/full?mibextid=Zxz2cZ
Swogger, M. T. et al. (2022). Understanding Kratom Use: A Guide for Healthcare Providers. Retrieved June 4, 2026 from https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.801855/full?mibextid=Zxz2cZ
