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Kratom as an Antioxidant Medicine

Posted By Jennifer Shipp | Jul 29, 2026

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Mitragyna speciosa: Antioxidant Effects

Kratom leaf extracts contain a number of different medicinal substances that have free radical-scavening abilities. Free radicals hasten aging and they can cause tissue damage that must be mitigated in order for the body to heal, so kratom can provide a service in regard to free radical damage. The bio-active alkaloids, mitragynine and 7-hydroxymitraginine are powerful antioxidants that have been scientifically studied in regard to their ability to reduce damage by free radicals.

Like vitamin C, kratom has the ability to reduce ferric iron (Fe3+) to ferrous iron (Fe2+) to make iron more bioavailable, enhancing its absorbability in the gut, its transport to the cells, and preventing anemia from developing. Without the conversion from ferric iron to ferrous iron, iron would be insoluble and biologically unavailable. This iron-converting ability of kratom makes it a good choice for those who have recently been ill with a major infection that disrupted iron availability in the body. Most infectious pathogens are pirating our iron and the body, as a result, generally sequesters iron during a major infection. Taking kratom can help treat the after-effects of an infection because it makes iron more bioavailable in the body.

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Kratom can protect the skin from damage by free radicals through its antioxidant capabilities, but the antioxidant power of this herb has also been used to suppress cancer cell proliferation. Kratom has been combined with chemotherapy in conventional medicine, particularly in HeLa cervical cancer to produce a “chemosensitizing” effect. In other words, kratom administered in combination with chemotherapy appears to make chemotherapy work better than when chemo is administered by itself. 

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Resources:


Kaewchompoo, S. et al. (2025). Cosmeceutical Potential of Mitragyna speciosa (Kratom): Anti-Adipogenic and Antioxidant Properties of Extracts and Mitragynine. Retrieved June 1, 2026 from https://pubmed.ncbi.nlm.nih.gov/41226215/ 

Kongsila, P. et al. (2026). Phytochemical profile and chemosensitizing anticancer activity of Mitragyna speciosa and mitragynine. Retrieved June 1, 2026 from https://www.nature.com/articles/s41598-026-43711-5 

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