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Medicinal Substances Found in Viburnum opulus / Guelder Rose

Posted By Jennifer Shipp | Oct 28, 2026

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Viburnum opulus: Medicinal Substances

Viburnum opulus is a very important herbal remedy for major childhood illnesses. We compare and contrast Viburnum opulus to Cinchona bark because these two herbal remedies share similar characteristics, yet with differing side effects. For children who will not be vaccinated for any reason and who are susceptible to major illnesses like measles, mumps, polio, etc. Viburnum opulus can be used as a part of a protocol to overcome these diseases naturally. Cinchona officinalis is also an appropriate choice for major childhood illnesses and in fact, this herb might be essential in overcoming certain diseases like HIV, tuberculosis, malaria, or a variety of other serious illnesses, but Viburnum is a bit gentler for kids. Here, we provide a non-exhaustive list of some of the major medicinal substances found in Viburnum opulus and what each substance does in the human body. 

Viburnum opulus contains the following medicinal substances: 



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  • Scopoletin 


Scopoletin is a coumarin that produces an antispasmodic action on smooth muscles. This medicinal substance, which is found in a number of different plants (e.g. Morinda citrifolia, Aegle marmelos, Erycibe obtusifolia, Lasianthus lucidus, Melia azedarach, Sinomonium acutum, Solanum lyratum, Convolvulus prostratus) has powerful medicinal effects:

  • Lowers blood pressure
  • Lowers fever
  • Calms the thyroid gland (antithyroid)
  • Shrinks cancerous tumors (antiproliferative)
  • Anti-inflammatory
  • Heals neurological issues
  • Mental health promoting effects (anti-dopaminergic) 
  • Antifungal
  • Antibacterial
  • Antiviral
  • Antiprotozoal
  • Natural treatment for tuberculosis (antitubercular)
  • Protects the liver
  • Antioxidant

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  • Chlorogenic Acid


Chlorogenic acid has an antimicrobial, anti-inflammatory, and antioxidant effect on the body. Chlorogenic acids can have a healing effect on the gastrointestinal system. They are derived from quinic acids.

  • Catechins and Epicatechin


These substances have astringent activity in the body.

  • Viopudial


This medicinal substance also has an antispasmodic action on smooth muscles.

  • Viburnin


Viburnin is a bitter medicinal compound that also has antispasmodic activity. 

  • Aesculetin


Aesculetin is a coumarin that acts as an antispasmodic.

  • Ursolic Acid


Ursolic acid is an anti-inflammatory via COX-2 inhibition and NF-kappaB modulation. 

  • Salicin


Salicin, a precursor to salicylic acid that has anti-inflammatory effects on the body, is found in the leaves and branches of Viburnum opulus. Other salicin-containing herbs like white willow are also powerful healers.

  • Quercetin
  • Kaempferol
  • Valerianic Acid


Valerianic acid has sedative and antispasmodic properties. It binds to GABA receptors and it has an activity similar to benzodiazepines. In high doses, valerianic acid is an anti-convulsive agent.

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Resources



Kundu, S. et al. (2024). Scopoletin alleviates high glucose-induced toxicity in human renal proximal tubular cells via inhibition of oxidative damage, epithelial-mesenchymal transition, and fibrogenesis. Retrieved April 25, 2026 from https://pubmed.ncbi.nlm.nih.gov/38709349/ 

Joshi, H. et al. (2021). Review on Scopoletin: A Phenolic Coumarin with Its Medicinal Properties. Retrieved April 25, 2026 from https://ijpsr.com/bft-article/review-on-scopoletin-a-phenolic-coumarin-with-its-medicinal-properties/#:~:text=Scopoletin%20has%20a%20number%20of%20pharmacological%20activities%2C,Antibacterial%20*%20Antifungal%20*%20Antitubercular%20*%20Antioxidant 

Al-Harbi, L. N. et al. (2022). Cinchona officinalis Phytochemicals-Loaded Iron Oxide Nanoparticles Induce Cytotoxicity and Stimulate Apoptosis in MCF-7 Human Breast Cancer Cells. Retrieved April 25, 2026 from https://pmc.ncbi.nlm.nih.gov/articles/PMC9565860/#:~:text=Plant%2Dbased%20nanoparticles%20have%20the,phytosterols%20have%20also%20been%20identified. 

Gbotolorun, S. C. et al. (2018). Quinine inhibits ovulation and produces oxidative stress in the ovary of cyclic Sprague-Dawley rats. Retrieved May 8, 2026 from https://pmc.ncbi.nlm.nih.gov/articles/PMC6306975/ 

Keri, R. S. and Patil, S. A.  (2014). Quinoline: A promising antitubercular target. Retrieved May 8, 2026 from https://www.sciencedirect.com/science/article/abs/pii/S075333221400136X 

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