Kratom: Anti-Obesity / Weight Loss Effects
Kratom / Mitragyna speciosa is a blood sugar regulator that can be used as a part of natural healing protocol for diabetes, so it stands to reason that this herb could also be beneficial in treating obesity and metabolic syndrome. We've watched this herb work for our clients and we've worked with kratom ourselves in a variety of health situations within our own family. Studies have shown that those who take kratom have a lower risk of developing a metabolic syndrome. Also, kratom use is associated with a smaller waist circumference, lower tri-glycerides, and higher levels of healthy cholesterol. And its safe for use in both children and adults. In Traditional Southeast Asian society, kratom has been used for centuries to treat fever, cough, and diarrhea in babies and young children.
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Kratom has an inhibiting effect on pancreatic digestive enzymes such as lipase and alpha-glucosidase. This herb contains quercetin a strong alpha-glucosidase inhibitor, but there seem to be other forces at work here too. Mitragynine is one of the more well-studied alkaloids found in kratom and this substance seems to work synergistically with quercetin to produce a stronger inhibitory effect against lipase and alpha-glucosidase. The end result is weight loss that occurs through a general balancing effect in regard to the body's relationship with blood sugars.Studies have shown that kratom extracts reduce fat accumulation. Scientists believe that quercetin plays a role by inhibiting Acetyl-CoA-carboxylase 1 (ACC1), a vital enzyme in the synthesis of fatty acids. Through this mechanism of action, kratom has an anti-obesity effect that essentially causes a reduction in fat accumulation in fat cells in the human body. So blood sugar is regulated, but lipids and fats in the body are also impacted by regular kratom administration.
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In addition to its anti-obesity effects, kratom also reduces inflammation in the body. Chronic inflammation can create the illusion of weight gain, in some instances, when, in fact, the additional pounds are there due to water weight around inflamed areas of the body. Regular kratom use may improve blood triglyceride levels and reduce Body Mass Index (BMI) while also killing pain and mastering inflammatory processes in the body.Kratom is an antidiabetic and an anticancer herb, but it is most famous, of course, for its ability to relieve pain naturally, get rid of depression, and reduce anxiety. Pain relief can also make it easier to exercise in order to lose weight, of course, but holistically, kratom is also known for its ability to treat digestive problems, particularly inflammatory conditions in the gut like Crohn's disease and ulcerative colitis. It is an antimicrobial herb with the ability to kill a broad range of different pathogens, including parasites, that might underlie a person’s weight gain.
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Resources:
• John’s Hopkin’s Medicine (2020). Natural Herb Kratom May Have Therapeutic Effects And Relatively Low Potential For Abuse Or Harm, According To A User Survey. Retrieved May 26, 2026 from https://www.hopkinsmedicine.org/news/newsroom/news-releases/2020/02/natural-herb-kratom-may-have-therapeutic-effects-and-relatively-low-potential-for-abuse-or-harm-according-to-a-user-survey
• La-up, A. et al. (2022). Association between kratom (Mitragyna speciosa) use and metabolic syndrome. Retrieved May 26, 2026 from https://pmc.ncbi.nlm.nih.gov/articles/PMC9124704/
• Janthongkaw, A. et al. (2023). Effect of Green and Red Thai Kratom (Mitragyna speciosa) on pancreatic digestive enzymes (alpha-glucosidase and lipase) and acetyl-carboxylase 1 activity: A possible therapeutic target for obesity prevention. Retrieved May 26, 2026 from https://pmc.ncbi.nlm.nih.gov/articles/PMC10513218/
