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Quinine, Cinchona Bark, and Beyond: Herbal Cure for Toxoplasmosis Infection

Posted By Jennifer Shipp | Jul 17, 2022

DISCLAIMER: CONSULT WITH A DOCTOR BEFORE DECIDING ON A TREATMENT PLAN FOR ANY DISEASE.

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Many people who have never heard of Cinchona officinalis or even "quinine" have heard of heavily marketed pharmaceuticals like hydroxychloroquine or chloroquine as medicines that were both useful in treating COVID, though they were downplayed by Big Pharma agents that wanted people to buy more expensive medications whose patents were still intact. But patients would be better off using just quinine, the natural substance found in Cinchona officinalis bark or better yet, the whole plant material as an herbal treatment for Toxoplasmosis because scientists have shown that quinine and Cinchona bark work better than the pharmaceutical drugs that are based on them.

What herb kills Toxoplasma? Home Remedies for Toxoplasmosis

Quinine is a substance found in Cinchona bark. Quinine comes from the Cinchona officinalis tree. This world famous substance, quinine, was responsible for eradicating the malaria protozoa from Europe and it is also an important medicinal substance that plays a major role in the Cinchona officinalis herbal remedy for toxoplasmosis, another common protozoal infection.  Studies on quinine itself and on patentable pharmaceuticals derived from quinine have shown that quinine-compounds have a strong anti-Toxoplasma action. Quinine, as a natural medicine, works by preventing tachyzoite proliferation. Quinine and quinine compounds found in the whole plant (a tree, actually) known as Cinchona officinalis are able to disrupt Toxoplasma mitochondrial membrane potential as well as adenosine triphosphate production (ATP–the main energy source for cells). It also produces a high number of reactive oxygen species that are able to kill toxoplasmosis protozoa. So Cinchona officinalis is a valuable medicine that works through more than one mechanism of action against toxoplasmosis.  In order to get the most out of Cinchona officinalis protocol, you will need to start slowly with this medicine, increase the dose for 2-3 weeks and combine it with other medicinal agents, and then begin doing hot and cold therapy where the patient spends 10 to 30 minutes in an infrared sauna followed by a 10-12 minute cold bath (ideally while doing Wim Hof breathwork as an autonomic nervous system reset). Quinine is the pharmaceutical that was derived from Cinchona bark, but we recommend that people work with Cinchona officinalis as a whole plant medicine. In some cases, it might be valuable to add a small amount of extra quinine using a high-quality tonic water syrup, but the whole Cinchona officinalis plant contains several medicinal agents besides just quinine to help patients overcome toxoplasmosis. Research into dihydroquinine, also known as hydroquinone, a newly developed synthetic pharmaceutical that’s derived from quinine, can be prescribed by doctors, but quinine or even the whole plant bark of the Cinchona officinalis tree may actually be MORE effective than either dihydroquinine or hydroquinine. Quinine and Cinchona bark are definitely more affordable than medicines you might get from your doctor, but if you would feel more comfortable getting a prescription medicine, consider showing your doctor scientific articles about quinine for toxoplasmosis as proof that these substances are valid treatments for toxoplasmosis infection. Note, however, that after centuries of use as an antimalarial, Cinchona officinalis and also quinine are still effective as a treatment for toxoplasmosis and many other diseases. Cinchona officinalis contains a number of medicinal agents that work together to prevent any type of toxic reaction from quinine and that enhance digestive system health at the same time so that nutrient and quinine absorption can be maximized. While you might feel tempted to go to a doctor to get a prescription drug that was synthesized in a lab by a scientist who knew that quinine is an effective natural remedy for toxoplasmosis, consider this:  this scientist’s job was to create a different, but similar molecule to the natural quinine molecule so that that the new molecule could be patented and sold at a huge profit. That scientist is trying to find a molecule that will work “well enough” but that will specifically not cure the disease caused by Toxoplasma gondii. This is his job. But you can work directly with quinine yourself using Cinchona officinalis in an herbal decoction (which is basically just a tea that’s simmered for 15 to 20 minutes) and you can administer tonic water syrup which contains quinine. Combine Cinchona officinalis with Artemisia annua as a source of artemisinin for a few weeks (we’ll talk about that more below, and you have a powerful remedy for Toxoplasma gondii) to improve the overall effectiveness of your Cinchona protocol and then switch to Cinchona with methylene blue for a few days. After that, you might wish to switch to a detoxifying protocol using Cinchona bark and Hemidesmus indicus for a few days before returning again to the Cinchona with Artemisia protocol. It is also important to note here that if you are dealing with symptoms of psychosis (schizophrenia) as a part of your symptom picture with regard to toxoplasma gondii, quinine has been used for centuries to treat a wide variety of mental health issues. Indeed, thorazine / chlorpromazine, the very first anti-psychotic drug ever developed was derived directly from quinine. When thorazine was first developed nurses would often do cold therapy with psychotic clients to bring them back to reality. Indeed, low-level infection and low-grade fever is something that quinine is specifically known for as a treatment. So interestingly, thorazine was used to cool the body during surgery in its earliest days. Surgeons regarded thorazine treatment during surgery as a way to put the body into a state of “cooling hibernation”.  We recommend that you start by working with Cinchona officinalis and Artemisia annua using a recipe that we describe below along with several other medicinal agents that complement the effects of this treatment. Patients should be exposed to sunlight daily without sunscreen and with as much sun exposed as possible to the most out of this treatment.

Toxoplasmosis Treatment



Get an exact weight for yourself in kilograms (if you are treating yourself). Administer 25 mg / kg of body weight of Cinchona officinalis. Powder the Cinchona bark pieces in a coffee grinder if they don’t come in a powder. Use a gram scale to measure the proper dose for the patient. 

Place the measured dose in a small amount of water and bring it to a boil. Watch it carefully. As soon as it comes to a boil, lower the heat down to a simmer. Simmer for 20 minutes.

Remove from heat and allow to cool.

Strain out the bits of Cinchona and capture the liquid which is your daily dose of medicine. 

Don’t take it all at once. It is more effective if you take a little bit of this Cinchona liquid throughout the day. For this reason, we recommend that you get some bottled bubbly water and combine your dose of Cinchona with the bubbly water so that you can drink the mixture (known as “tonic water”) throughout the day. Aim to be drinking the tonic water mixture over the course of 6 to 8 hours of every day.

NOTE: In one  2012 animal study by Garavita, et al. on animals, titled The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine, scientists combined the use of quinine with an over-the-counter medication known as methylene blue. Methylene blue was given in a relatively high dose at 15 mg/ kg of body weight via IV. 

We don’t recommend that you administer 15 mg/kg of MB orally. In our experience a much lower dose produces a fairly noticeable effect when combined with Cinchona officinalis. Start with 1.5 mg / kg body weight of MB and increase the dose up to 3 mg / kg body weight if necessary for up to 4 days at a time. Then change to a different herbal Cinchona protocol for 1 month before working with MB again.

Within our family, we have used a modified version of this protocol for infections at 1/10th of this dose (between 1-2 mg/kg of body weight) with infrared sauna treatments at twice daily for 15 minutes given at 2 hours after methylene blue doses are given (when the methylene blue hits peak concentration). It is very difficult to give 15 mg/kg of methylene blue by mouth because it is bitter and nauseating. Some people have serious negative reactions to methylene blue, especially at higher doses. Also note that methylene blue should not be given to anyone who is taking an MAOI, SSRIs, or any drug that alters serotonin levels. 

That being said, the administration of methylene blue is given over the course of just 24 to 48 hours with sauna treatments and it is quite effective at getting rid of infections involving hemolytic pathogens. We have administered methylene blue with the Cinchona officinalis dose above to a child ages 2 and up with very good results. For kids, methylene blue should be given in a low dose that’s based on body weight (we recommend 1 mg / kg body weight for kids under age 5) and then the child needs to be observed for 24 hours before proceeding. Watch for signs of breathlessness or changes in body color (yellowing of the skin and eyes) or any signs of odd behavior or lethargy. If the child reacts to the methylene blue okay, proceed with dosing at 1 mg / kg.

This is a powerful treatment for toxoplasmosis infection. You can begin with the toxoplasmosis prevention protocol for a week to prevent a major detoxification reaction and then work with higher doses of Cinchona officinalis and Artemisia annua (make sure the Artemisia is prepared fresh daily) and sun exposure (without sunscreen to ensure that the hydrogen peroxide system of the body is activated). Then, after 7 to 10 days, proceed to working with Cinchona officinalis and methylene blue at the doses recommended here for only 2 to 4 days. Return to Cinchona officinalis with Artemisia annua after you complete your protocol with the methylene blue.

Toxoplasmosis Prevention



For infection prevention, administer Cinchona officinalis at a dose of 3000 mg per day for adults. Follow the instructions above for working with Cinchona as a dried herb.

Lugol’s Iodine 2% Dosage: 

Administer ​ 2% Lugol’s iodine at a dose of 1 drop to the wrist daily. Increase the dose by 1 drop per day. You can also put the drops in water and then drink the water. Read more about Lugol’s iodine here, to find out what to expect from this essential trace mineral that has the ability to get rid of Toxoplasma gondii and other serious diseases.  As an expectorant, potassium iodine is prescribed at a 300-600 mg dose taken 3-4 times daily in 8 ounces of water, juice, or milk. Potassium iodide can be used by itself, but we recommend working with Lugol’s iodine because Lugol’s has a broader spectrum of action in the body. Remember though, Lugol’s iodine contains potassium iodide at a lower dose. Taking 20 drops of Lugol’s iodine 2% may be enough to treat a disease like Toxoplasma gondii that doesn’t involve a respiratory component like tuberculosis. Increase the dose slowly as you begin to use the Lugol’s iodine.

Herbal Remedy for Toxoplasmosis #1: Quinine and Artemisinin

Quinine is a substance that’s found in Cinchona bark. Artemisinin is a substance that’s found in the plant known as Artemisia annua. Though most scientific studies have focused on artemisinin and quinine, using the whole plant material is a better choice for toxoplasmosis treatment. If you use the whole plant materials, Cinchona officinalis and Artemisia annua, rather than quinine and artemisinin you will be administering a powerful group of medicines that work together to heal toxoplasmosis holistically. Cinchona officinalis contains quinine. Artemisia annua contains artemisinin. Both of these plants also contain other medicinal agents that enhance the overall medicinal effect of quinine and artemisinin. Artemisia annua releases hydrogen peroxide, a reactive oxygen species medicine that’s particularly powerful when the body is exposed to sunlight or full-spectrum light within about an hour after you take this herb. So get some sunlight about an hour after you administer the first dose Artemisia annua Expect to do at least one of the protocols and treatments in this discussion for 2-3 months or longer depending on the patient’s needs. At first, progress will be noticeable, but slow and with cycles of improvement followed by cycles of what seem to be setbacks. Continue on religiously with this protocol. The patient should rest in bed as much as possible for the first 4-6 weeks of treatment to allow the blood supply to slowly rebuild as the Cinchona and Artemisia are kiling toxoplasmosis pathogens. We also recommend that patients combine the use of these herbal remedies (Cinchona officinalis and Artemisia annua or Cinchona officinalis and Smilax medica) for toxoplasmosis with the following:
  • Red wine (1 teaspoon) - administered up to 8 times per day, ideally with food. It’s important to note here that toxoplasmosis can cause iron-deficiency and a state of anemia. Sometimes this will show up in lab results. Sometimes it does not. Drinking small doses of red wine throughout the day can quickly improve iron levels. 
    • DO NOT GIVE IRON SUPPLEMENTS. Iron is easily recycled in the body so iron should only be given in the form of red meat and foods like blackstrap molasses that contain iron already. Iron supplements given to a patient with an infectious pathogen that consume heme in our blood cells to harvest iron can lead to a more serious infection. Rather, give copper supplements, ideally in food-form. Red wine is a good source of both iron and copper in a bioavailable form that’s easy to absorb because of the alcoholic content. Consume the red wine by itself and with the red meat (see below).
  • Red meat (1-3 servings per day)  - red meat and red wine are given to help the patient overcome anemia and iron deficiency that might not even show up on lab results
  • Melissa officinalis (4 grams per day) - This herb is given as a tea that can be drunk throughout the day or in one sitting. It is given to regulate insulin levels and to support the thyroid gland.
  • Green coffee - Green coffee is high in quinic acids that lower inflammation in the gut. Many patients with toxoplasmosis are not able to overcome the disease because their gastrointestinal system is inflamed and as a result, they aren’t absorbing the nutrients they need in order to overcome this infection.
Dosage and Administration Methods:

Dosing with Extracts: 

As extracts, you can administer Artemisia annua extract twice daily at a dose of 5 grams per day (administer it twice daily.  Also as an extract, you can put 10 mg / kg of the patient's body weight of the Cinchona officinalis Bark extract into a “master tonic” that contains 4 to 8 ounces of water. Administer this tonic at least 8 times daily in divided doses. In other words, make a tonic water using Cinchona officinalis and then administer this tonic water throughout the day.

Dosing with Dried Herbs:

If you have access to powdered Cinchona officinalis and Artemisia annua, administer at a dose of 25 mg / kg of powdered Cinchona bark (use a coffee grinder to powder it if it arrives in chunks) daily. Use a gram scale to measure the dose according to the patient’s body weight. Place the full dose of Cinchona officinalis in about ¼ to ½ cup of water. Bring it to a boil and then lower the heat immediately to a simmer for 15 to 20 minutes.  Remove the pot of water with Cinchona bark in it from the stovetop. Let it cool and strain it before you add it to a bottle of bubbly water. Add stevia to taste. If the patient responds well to this treatment for 7 days, consider adding 1 teaspoon of Top Hat tonic water to this tonic water mixture daily. In a separate pot, bring 500 mL of water to a boil. Remove the water from the heat immediately and combine it with 5 grams of Artemisia annua. Allow it to cool for 15 minutes before you strain it. Administer the Artemisia annua tea twice daily while the patient is sitting in the sunlight, if possible.



Click here to buy Hawaii Pharm's Artemisia annua Wormwood extract. 

DO NOT GIVE MAGNESIUM OR VITAMIN C TO THE PATIENT WITHIN 2 HOURS (BEFORE OR AFTER) ADMINISTERING THIS TREATMENT. Magnesium can interfere with the body’s use of quinine and vitamin C can destroy the medicinal reactive oxygen species that kill pathogens like Toxoplasma gondii. Scientists and doctors have successfully used QUININE against protozoan infections and there is quinine in Cinchona bark. The recommended dose of quinine (as an isolated medicinal substance) is 10 mg per day given in DIVIDED DOSES given every hour for 8 hours over the course of 7 days. So you’d make a 10 mg master solution of quinine at the beginning of the day and then you’d administer 1/8th of this master solution each hour for 8 hours of the day. Combine this treatment with two doses (morning and night) of 2500 mg of Artemisia annua (5 grams total per day). This treatment strategy of administering the quinine (or Cinchona bark) hourly is more effective than giving the quinine in bigger doses twice daily. Note that this consistent, hourly dosing is the same dosing strategy recommended for Chlorine Dioxide Solution / Miracle Mineral Supplement. It is more effective to administer hourly doses of 1/8th of the quinine master solution 8 times per day than to administer ½ of the quinine master solution in the morning and ½ at night. 

Note that both quinine / Cinchona Bark and artemisinin / Artemisia annua release reactive oxygen species as medicinal agents that have the ability to kill Toxoplasmsa gondii.





Click here to buy Hawaii Pharm's Cinchona Bark extract. 



If you have access to powdered Cinchona officinalis and Artemisia annua, administer 3000 mg of powdered Cinchona bark (use a coffee grinder to powder it if it arrives in chunks) daily. Use a gram scale to measure the dose. Place the full dose of Cinchona officinalis in about 1 liter of water. Bring it to a boil and then lower the heat to a simmer for 15 to 20 minutes.  Remove the pot of water with Cinchona bark in it from the stovetop. Add 5 grams of Artemisia annua to this mixture immediately as the water begins to cool. Administer this treatment 5 to 8 times throughout the day. DO NOT GIVE MAGNESIUM OR VITAMIN C TO THE PATIENT WITHIN 2 HOURS (BEFORE OR AFTER) ADMINISTERING THIS TREATMENT. Magnesium can interfere with the body’s use of quinine and vitamin C can destroy the medicinal reactive oxygen species that kill pathogens like Toxoplasma gondii. In this scientific research article, the author talks about the use of QUININE against protozoan infections. The recommended dose is 10 mg per day given in DIVIDED DOSES administered every hour for 8 hours over the course of 7 days. So you’d make a 10 mg master solution at the beginning of the day and then you’d administer 1/8th of this master solution each hour for 8 hours of the day. Combine this treatment with two doses (morning and night) of 2500 mg of Artemisia annua. This treatment strategy of administering the quinine hourly is more effective than giving the quinine in bigger doses twice daily. Note that this consistent, hourly dosing is the same dosing strategy recommended for Chlorine Dioxide Solution / Miracle Mineral Supplement. It is more effective to administer hourly doses of 1/8th of the quinine master solution 8 times per day than to administer ½ of the quinine master solution in the morning and ½ at night. So despite the fact that this dosing strategy is less convenient, consider doing it this way (multiple daily doses administered regularly) because it’s more effective. Note that both quinine / Cinchona Bark and artemisinin / Artemisia annua both release reactive oxygen species as medicinal agents that have the ability to kill Toxoplasmsa gondii.

Herbal Remedy for Toxoplasmosis #2: Cinchona Bark + Sarsaparilla + Potassium Iodide

  Sarsaparilla (also known as Smilax medica) and Cinchona bark are two herbs that work very well together. Sarsaparilla has a lot of medicinal functions that Cinchona officinalis has too, so you could say that these two herbs amplify each other’s effects. Sarsaparilla is able to kill pathogens like protozoa and amoeba infections. It has the ability to purify the blood. And sarsaparilla does an excellent job of regulating digestion and getting rid of fevers too.   Indeed, Cinchona officinalis is also known as the Fever Tree because it does such an amazing job of lowering certain types of fever.   But most importantly, sarsaparilla likes to work in partnership with other herbs like Cinchona bark to kill Toxoplasma gondii by increasing the strength of quinoline, quinine, and some of the other alkaloids that have a medicinal action against Toxoplasmosis   This article is about the use of Cinchona Bark / Quinine, sarsaparilla, and potassium iodide as a cure for tuberculosis but it is also relevant to the treatment of Toxoplasmosis infection. The Cinchona bark (which contains quinine)  is the primary anti-protozoa agent while Sarsaparilla enhances the strength and absorption of the medicinal agents in the Cinchona bark. Potassium Iodide, in contrast, improves lung function and expectoration (the removal of phlegm from the body) as well as general immune function. Lugol’s iodine Therapy is another recommended natural treatment for Toxoplasmosis. Read more here about how to use Lugol’s iodine and vitamin K2 to overcome diseases of toxicity that are resistant to treatment.   Note that Cinchona Bark CONTAINS quinine as well as other alkaloids like quinonline and quinic acids. Quinoline also has a broad spectrum of medicinal action. Quinic acids do too. Though you cannot currently buy quinoline with the same ease with which you can buy quinine, the whole plant material, Cinchona Bark contains both quinine and quinoline that work together with sarsaparilla and iodine to cure Toxoplasmosis. Note here that you can purchase quinine as “tonic syrup” in some countries.



Natural Treatments and Cures for Toxoplasma gondii Infection - BUY HERE!

  I recommend the whole herb material of Cinchona Bark to most people because it contains other medicinal substances other than just quinine that can all work together to cure Toxoplasmosis infection. Sarsaparilla contains saponins that enhance the effects of cinchona by helping quinine and other medicinal substances in Cinchona Bark (such a quinoline) gain admittance to sick cells, but sarsaparilla also has a medicinal action against protozoa infections like Toxoplasmosis. These two medicinal agents work well together to treat Toxoplasma gondii naturally.   Potassium Iodide is a component in Lugol’s iodine. Lugol’s contains molecular iodine and potassium iodide so it feeds both the thyroid gland and the reproductive organs. Lugol’s iodine was once the most widely prescribed medicine in the United States before the American Medical Association took over and began creating petroleum-based pharmaceuticals. The story of iodine and how it has been removed from the food supply in the United States to the detriment of the entire population’s health is important in understanding how Lugol’s iodine can be used to naturally treat Toxoplasmosis. Lugol’s iodine balances the immune system and also helps make the body resistant to all infectious diseases including Toxoplasmosis

 Click here to buy Lugol's Iodine 2%. 



Cinchona Bark and Sarsaparilla: 

Administer these extracts together simultaneously according to the dosing instructions on the bottles. 

Lugol’s Iodine 2% Dosage: 

Administer ​ 2% Lugol’s iodine at a dose of 1 drop to the wrist daily. Increase the dose by 1 drop per day. You can also put the drops in water and then drink the water. Read more about Lugol’s iodine here, to find out what to expect from this essential trace mineral that has the ability to get rid of Toxoplasma gondii and other serious diseases.  As an expectorant, potassium iodine is prescribed at a 300-600 mg dose taken 3-4 times daily in 8 ounces of water, juice, or milk. Potassium iodide can be used by itself, but we recommend working with Lugol’s iodine because Lugol’s has a broader spectrum of action in the body. Remember though, Lugol’s iodine contains potassium iodide at a lower dose. Taking 20 drops of Lugol’s iodine 2% may be enough to treat a disease like Toxoplasma gondii that doesn’t involve a respiratory component like tuberculosis. Increase the dose slowly as you begin to use the Lugol’s iodine.

Click here to buy The Iodine Bible.



As an expectorant, potassium iodine is prescribed at a 300-600 mg dose taken 3-4 times daily in 8 ounces of water, juice, or milk as a secondary option. Remember though, Lugol’s iodine already contains potassium iodide at a lower dose. Taking 20 drops of Lugol’s iodine 2% may be enough to treat a disease like Toxoplasma gondii that doesn’t involve a respiratory component like tuberculosis.

Click here to buy Hawaii Pharm's Sarsaparilla tincture here. 





Resources:


Achan, J. et al. (2011). Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria. Retrieved July 17, 2022 from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121651/


Fayer, R. et al. (1972). Quinine inhibition of host cell penetration by Toxoplasma gondii, Besnoitia jellisonia, and Sarcocystis sp. In vitro. Retrieved July 17, 2022 from https://pubmed.ncbi.nlm.nih.gov/4625324/


Huffman, A. M. et al. (2022). Inhibition of Toxoplasma gondii Growth by Dihydroquinine and Its Mechanisms of Action. Retrieved July 17, 2022 from https://pubmed.ncbi.nlm.nih.gov/35646733/


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