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Selank and Semax to Treat Addiction at Home

Posted By Jennifer Shipp | Jun 25, 2021

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Nootropic Medications for Addiction Treatment

What is Semax?

Semax is a drug that is used most commonly in Russia and the Ukraine though it is available in other countries over-the-counter in some situations. It is a nootropic that has neuroprotective properties. Semax is a synthetic peptide that is based on a fragment of Adrenocoroticotropic Hormone (ACTH). 

In Russia, Semax is on the List of Vital and Essential Drugs that are approved by the Russian government. It is used for the treatment of the following:





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  • Addiction
  • Memory and cognitive disorders
  • Peptic ulcers
  • Gastric protection
  • Optic nerve disease
  • Immune System enhancement
  • Stroke (it works by affecting the expression of genes that impact the immune system and vascular system after a stroke). 
  • Transient Ischemic Attack
  • Depression
  • Anxiety
  • ADHD
  • ADD
  • Antioxidant


Semax increases the level and the expression of Brain Derived Neurotrophic Factor (BDNF) while activating the serotonergic and dopaminergic brain systems. As such, it acts like an antidepressant as well as sometimes an anti-anxiety medication. However, depending on the dose, Semax can actually cause anxiety. Semax helps rebuild the brain after a stroke and it can also help to reduce some of the undesirable effects of dealing with chronic stress. Semax and a related synthetic peptide, Selank can have a positive effect on the perception of pain. 

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How to Use Semax for Addiction

Semax has poor bioavailability when taken by mouth, so it is generally administered as an intranasal spray or as a subcutaneous injection.

It’s important to get the dosing right for Semax if you’re using it to treat addiction. It has been studied most extensively as a cure for opiate addiction and in fact, it may make withdrawal symptoms worse in stimulant addiction. Small doses of Semax are best as a treatment for opioid addiction. Ad ose of 0.05 mg/kg reduces morphine withdrawal symptoms in rats by 36.4%. Higher doses of Semax are not effective at reducing withdrawal symptoms from morphine or other opiates. 

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Semax for Alcohol Addiction

Semax is a peptide that’s been used in Russia in clinical practice for human alcohol dependency. It is administered at a dose of 50 micrograms per kilogram body weight of the patient daily for 10 days. 

In animal studies, Semax showed an increase in body movement and exploratory behavior and a decrease in depression. However, Semax in animal studies has also been shown to increase anxiety at higher doses. In fact, at a dose of 200 micrograms per kilogram body weight, animal subjects sought out more alcohol. At the lower dose of 50 micrograms, there was no pro-alcohol effect.

There are no side effects associated with Semax at 50 micrograms daily. Tolerance for the medicine is very good and this peptide alleviates acute withdrawal symptoms with an efficacy similar to that of Piracetam. To be clear though, Semax does not get rid of alcohol cravings and at higher doses may have even made alcohol cravings worse. However, Semax has been used therapeutically in patients who have poor blood circulation to the brain. It improves learning and enhances exploration and curiosity while reducing physical pain and inflammation in the body. 

Semax is often used to enhance nerve regeneration following traumatic brain injury or stroke. It is also used in alcohol addiction to treat neural damage that has occurred as a result of chronic exposure to alcohol

Anecdotal reports by those in alcohol recovery who used Semax indicate that this nootropic increases a person’s tolerance to alcohol by perhaps inhibiting the GABA receptors. As such, Semax by itself is not usually recommended. Rather, it is always used in combination with another peptide known as Selank.

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Semax and Selank for Alcohol Addiction

Semax and Selank are typically used together for alcohol dependency. Both Selank and Semax are melanocortin peptides that are pleiotropic. Pleiotropism means that they can change shape in the body depending on what the body needs.

While Semax can increase energy levels and anxiety, Selank is usually prescribed to reduce anxiety as well as depression. Selank has a pronounced anti-anxiety effect in the body and it acts as a stable anti-stress medicine and antidepressant.

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Selank and Semax act as Melanocortin Stimulating Hormone-like peptides in the brain to produce a wide range of different effects pertaining to brain health and fitness. While Semax has a healing effect on the brain and nervous system, it produces high-energy states. In contrast, Selank is prescribed for its ability to reduce anxiety, improve immune system function, protect the digestive system and to treat opioid and alcohol withdrawal and dependence. Semax is particularly useful in the treatment of ADHD, ALS, Parkinson’s disease, and Alzheimer’s. It has been used as an alternative to Adderall.

The combination of Semax and Selank is particularly beneficial for patients with alcohol addiction who wish to improve their mental clarity, memory, focus and also reduce anxiety and depression. The medicines can be helpful in overcoming Post-Traumatic Stress Disorder (PTSD).

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Semax and Selank Dosing

Note that nootropics and peptides like Semax and Selank have been studied for their ability to help alcoholics overcome addiction naturally too. Both are administered either as subcutaneous injections or as nasal spray.

  • Semax: Take 50 micrograms per day for 10 days. 

  • Selank: Take 0.3 mg/kg of body weight. Selank reduces anxiety and other unpleasant symptoms during withdrawals.


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Resources:


Lovat, M. et al. (2008). The influence of Semax nootropic agent on the behavioral signs of the withdrawal syndrome and on the craving for alcohol in white rats and the determination of its clinical efficacy and safety in patients with alcohol dependene. Retrieved June 23, 2021 from https://www.researchgate.net/publication/226337169_The_influence_of_the_Semax_nootropic_agent_on_the_behavioral_signs_of_the_withdrawal_syndrome_and_on_the_craving_for_alcohol_in_white_rats_and_the_determination_of_its_clinical_efficacy_and_safety_in_


Wikipedia (2021). Semax. Retrieved June 22, 2021 from https://en.wikipedia.org/wiki/Semax


Andreevaa, L. A. et al. (2009). Antiviral Properties of Structural Fragments of the Peptide Selank. Retrieved June 23, 2021 from https://lindgren.health/images/downloads/Copy_of_Antiviral_properties_of_structural_fragments_of_the_peptide_Selank.pdf


Hoffman, B. (2020). The Amazing Benefits of Peptides. Retrieved June 23, 2021 from https://chiropractorsouthelgin.net/the-amazing-benefits-of-peptides/

Konstantinopolsky, M.A. & Kolik, L.G. (n.d.). P.6.c.014. ACTH4-10 analogue Semax and Adamantane derivative Hemantane produce significant reduction of withdrawal signs in morphine-dependent rats. Retrieved June 23, 2021 from https://www.ecnp.eu/presentationpdfs/71/P.6.c.014.pdf


Wikipedia (2021). Selank. Retrieved June 23, 2021 from https://en.wikipedia.org/wiki/Selank

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