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The Antioxidant Protocol for Long COVID Treatment at Home

Posted By Jennifer Shipp | Oct 27, 2021

DISCLAIMER: CONSULT WITH A DOCTOR BEFORE DECIDING ON A TREATMENT PLAN FOR ANY DISEASE.

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The Antioxidant Cure for COVID

Below is a mitochondria enhancing protocol for Long COVID sufferers. These antioxidant medicines work together to promote mitochondrial health and increased energy production in cells to alleviate the following symptoms of Long Haul COVID / Long COVID:

  • Fatigue / Lethargy
  • Shortness of breath
  • Pounding heartbeat
  • Chronic cough
  • Chest pain
  • Joint pain
  • Memory problems
  • Insomnia
  • Muscle pain
  • Headache
  • Depression 
  • Anxiety
  • Dizziness upon standing
  • Symptoms that get worse after physical or mental exertion


PQQ, Coenzyme Q10 (ubiquinone or ubiquinol), and L-Carnitine work closely together to improve mitochondrial health and thus improve the overall energy production of cells, but D-Ribose is central to the curing Long COVID symptoms using this protocol. Additionally, we talk about magnesium and vitamin B complex, nutrients that are absolutely essential for recovery from Long COVID using this protocol.

This protocol may need to be “pulsed” or alternated with 3 to 7 days (or even on and off every 10 days depending on your symptoms) of oxidant therapies using chlorine dioxide to fully regain one’s health when mitochondrial levels are very low. 

Methoxatin / PQQ Effects on Mitochondria

Pyrroquinoline quinone (PQQ), is also known as Methoxatin. PQQ is a quinone disodium salt. It is famous as an anti-aging, longevity vitamin. PQQ supplements are manufactured by bacteria and it is found naturally in a wide variety of fruits and vegetables. 
PQQ Extra Strength 40mg 50 Vegetarian Capsules Yeast Free by Now Foods NOW Foods PQQ 40mg Strength
PQQ was recently identified in human breast milk which sparked interest in how it functions in the body and what it can do for human health. Scientists who research PQQ have speculated that PQQ is actually a vitamin and an essential nutrient that acts as a “redox modulator”. In other words, it appears to have the ability to modulate or balance how many oxidants and antioxidants are circulating in the body. 

Mitochondria are vulnerable to oxidative damage, but PQQ has the ability to protect mitochondria against damaging oxidative processes such as, stress-induced lipid peroxidation, protein carbonyl protein formation, and the inactivation of the mitochondrial respiratory chain. 

But while PQQ can work against oxidants, it also appears to promote the activity of oxidants in certain biological environments. 

PQQ is often used by healthy people to increase energy and enhance memory.PQQ is regarded as a “mitochondrial generator” that performs the following functions in the body:

  • Protects the nerves 
  • Protects the mitochondria
  • Promotes nerve growth and brain functioning as well as overall brain health
  • Improves blood flow to the cerebral cortex
  • Boosts energy
  • Improves memory
  • Enhances focus
  • Anti-diabetic
  • Anti-inflammatory (PQQ works by lowering interleukin-6 and C-reactive protein levels)


PQQ DOSE: Take 20 mg per day with or without food.

Coenzyme Q10 / Ubiquinone or Ubiquinol

Coenzyme Q10 is an antioxidant. It can be taken in the form of either ubiquinone or ubiquinol. Both are bioavailable and they both offer important health benefits for people with an active COVID-19 infection as well as for COVID long haulers. 

CoQ-10 120 mg 60 VCapsules Yeast Free by Solgar CoQ10 120mg by Solgar
COVID-19 is characterized by a dysregulation of the immune system that features T-cell exhaustion and high levels of pro-inflammatory cytokines (“cytokine storm”). Scientists have demonstrated that mitochondrial dysfunction plays a role in the development of COVID-19 and as such, mitochondria may also be responsible for the abnormal immune response that’s been observed in complicated COVID cases.  Coenzyme Q10 (in the form of either ubiqinone or ubiquinol) is arguably the most important of the mitochondrial enhancers. It has the ability to carry electrons from one area of the electron transport chain to another along the mitochondrial membranes. It reduces oxidative stress and it has been used successfully to reduce the symptoms of a number of diseases.

Ubiquinone and ubiquinone are bioavailable forms of Coenzyme Q10 that have been used to boost the health of mitochondria in cells. These supplements can be used to treat a number of different diseases and may play an important role in reducing cytokine storms. Ubiquinol is generally recommended for older patients. Scientists have noted that Ubiquinone is able to restore the functioning of T cells that are exhausted in COVID patients. It works by alleviating mitochondrial dysfunction.

The best coenzyme Q10 product should contain either ubiquinone or ubiquinol in soft-gel capsules. Experts suggest that coenzyme Q10 should be used as part of a healing protocol as an adjunct therapy. It may take up to a month for your coenzyme levels to plateau and normalize if you take 200-300 mg per day.

Ubiquinone / Ubiquinol DOSE: Take 200-300 mg per day in the morning.

L-Carnitine and Acetyl L-carnitine



L-Carnitine 1000 mg - 100 Tablets Yeast Free by Now Foods NOW L-Carnitine 1000mg
L-Carnitine and Acetyl L-carnitine are antioxidants. Though both L-Carnitine and Acetylcarnitine have the ability to improve energy levels in the body, L-Carnitine is superior to acetylcarnitine in terms of fatty acid metabolism. L-Carnitine helps the body use fat as energy by transporting fatty acids to mitochondria. If you’re deficient in L-Carnitine, your body will not be able to efficiently metabolize fats. 
Acetyl L-Carnitine 120 Capsules Yeast Free by Doctor's Best Acetyl L-Carnitine 1000mg
Mitochondria love fats so L-Carnitine’s ability to transport fats to the mitochondria can improve energy levels after COVID-19. About 60 to 70% of mitochondrial energy comes from fat metabolism. But that’s not all! In addition to its ability to transport fats to the mitochondria to be used as an energy source, L-Carnitine is also able to soak up lactate and reduce ammonia production after exercise. These byproducts of anaerobic metabolism can cause aches and pains in the body that can be alleviated by L-Carnitine. Research has shown that L-Carnitine may improve oxygen levels in the muscles too. 

The effects of L-Carnitine begin just 1-2 hours after ingesting it. 

L-Carnitine DOSE: Take 1000-1200 mg per day at the same time as Ubiquinone/Ubiquinol. 

D-Ribose: How to Increase Energy Levels after COVID



D-Ribose 8.8 oz Powder Yeast Free by Doctor's Best Supplemental D-Ribose Powder
D-Ribose is a sugar and it is very sweet, but it won’t affect insulin or glucose levels. This supplement can be used as pure D-Ribose or as D-Ribose combined with malic acid/magnesium. Though D-Ribose does not affect insulin and glucose levels, it may still cause digestive upsets in some individuals because it is a sugar. If this happens to you, dissolve it in your mouth before swallowing it and reduce the daily dose to 5 grams per day.  D-Ribose plays an important role in the metabolic pathways that generate NADPH, ribose-5-phosphate, and 5-carbon sugars. Taking D-Ribose promotes the production of NADPH and ATP. Without adequate levels of D-Ribose, mitochondria will not be able to function properly. It binds with purines/pyrimidines to create a structure for these substances that can be used to build vital final products like DNA, RNA, or ATP. 

A number of studies have shown that D-Ribose can be beneficial to people with chronic fatigue and there’s reason to believe that this substance, in conjunction with the other antioxidants in this protocol is able to reduce muscle soreness, improve muscle recovery and energy levels, promote mental clarity, diminish the intensity of pain, and inhibit free radical production. Chronic fatigue patients who used D-Ribose have reported about a 30% improvement in their symptoms using D-Ribose.

Most D-Ribose products are produced from corn, but people who are sensitive to corn should seek out a corn-free D-Ribose product. 

D-Ribose DOSE: Take 15 grams of D-Ribose daily for two weeks and then 10 grams per day thereafter.

Alpha Lipoic Acid for COVID

Alpha Lipoic Acid 600 mg - 50 Tablets Yeast Free by Solgar Alpha Lipoic Acid 600mg by Solgar
Alpha Lipoic Acid is another antioxidant with potent anti-inflammatory effects as well as immune-modulating effects that have been studied by researchers trying to find ways to calm a cytokine storm. It is made naturally in the body and it is also found in certain foods.  Alpha Lipoic Acid has the ability to reduce a cytokine storm by regulating T cell activation. And it has also been used with L-Carnitine and Coenzyme Q10 (ubiquinone or ubiquinol) to cure Long COVID. L-Carnitine, Coenzyme Q10, N-Acetylcysteine (NAC), and Alpha Lipoic Acid have synergistic effects that work very well together.

We discuss NAC as a cure for COVID in greater depth in this article.

Note that Alpha Lipoic Acid has been used to restore sense of smell following COVID-19 infection.

Alpha Lipoic Acid DOSE: Take 600 mg per day at the same time as L-Carnitine and Coenzyme Q10 for best results.

Magnesium Chloride to Improve Mitochondrial Function During Long COVID: Antiviral Properties and More

Magnesium Chloride can be used not only as an important nutrient in the biochemical reactions that are necessary for the above antioxidants to work together properly, but it can also be used as an anti-viral. Magnesium chloride has impressive antiviral capabilities and it is absorbed relatively well by the body. 

Magnesium DOSE: Start at 75 mg per day and build up to 600 mg per day over the course of 1-3 months. 



Vitamin B Complex for Long COVID

Vitamin B-100 Sustained Release 100 Tablets Yeast Free by Now Foods NOW Vitamin B-100 Complex
As with magnesium, you need to make sure that you’re taking a good vitamin B complex supplement in order for the antioxidants listed above to work properly in the body. 

Omega 3’s and the Budwig Diet for COVID-19

Cod Liver Oil 8.4 fl oz (250 ml) Yeast Free by Carlson Labs Carlson Cod Liver Oil, Lemon Flavor
Taking a high-quality Omega fatty acid supplement will supercharge this antioxidant protocol. Take a daily dose of Cod Liver Oil and consider doing the Budwig Diet if you have Long Haul COVID. The Budwig Diet is a special smoothie recipe of flaxseed oil and coconut milk plus fruit (usually consumed while sitting in the sunlight). Don’t underestimate this special concoction of fats and proteins that was developed by one of the worlds most knowledgeable experts on fats in the human body. Dr. Budwig cured many different types of disease using nothing but the Budwig Protocol. The mechanism of action behind the Budwig Diet is roughly comparable to how Methylene Blue works in the body. When the Budwig Smoothie is consumed in the sunlight, it allows the body to absorb photons of energy from the sun. Methylene Blue can be used in similar manner with Red Light Therapy and though these two forms of therapy are very different biochemically, they both help human cells raise their energy levels. Drinking several Budwig smoothies daily while dosing oneself with sunlight for 15-30 minutes each day can significantly improve energy levels and general health over time. 

How to make the Budwig Smoothie:

1 Serving -  In a blender on high speed, mix 1 Tablespoon of cold-pressed flaxseed oil with 2 Tablespoons of Coconut, Soy, or Almond Milk. After the milk is completely mixed with the oils, add fruit. DO NOT ADD THE FRUIT BEFORE MIXING THE MILK and OILS OR THIS RECIPE WILL NOT HAVE THE SAME HEALTH EFFECTS.  

Drink this smoothie up to 3 times per day while sitting in the sun. 



COVID-19 and Respiratory Infection Self treatment and Prevention BUNDLE - Volumes 1, 2, and 3









Resources:


He, K. et al. (2003). Antioxidant and pro-oxidant properties of pyrroloquinoline quinone (PQQ): implications for its function in biological systems. Retrieved October 26, 2021 from https://pubmed.ncbi.nlm.nih.gov/12473380/


Bishop, A., Gallop, P. M., Karnovsky, M. L.  (1998). Pyrroloquinoline quinone: a novel vitamin? Retrieved October 26, 2021 from  https://pubmed.ncbi.nlm.nih.gov/9810806/


Johnson, C. (2020). Mitochondrial Enhancers for Chronic Fatigue Syndrome (ME/CFS) and Fibromyalgia Pt. I: D-Ribose, CoQ10, and PQQ.Retrieved October 26, 2021 from https://www.healthrising.org/blog/2020/12/18/5mitochondria-coq10-d-ribose-fibromyalgia-chronic-fatigue-syndrome/


Ouyanga, L., Gong, J. (2020). Mitochondrial-targeted ubiquinone: A potential treatment for COVID-19.  Retrieved October 26, 2021 from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403158/  

Mayo Clinic (2021). COVID-19 Long Term Effects. Retrieved October 26, 2021 from https://www.mayoclinic.org/diseases-conditions/coronavirus/in-depth/coronavirus-long-term-effects/art-20490351


Goodman, J. (2018). Cognitive Supplement Spotlight, Vol. 4: PQQ. Retrieved October 26, 2021 from https://drgoodmannd.com/2018/07/cognitive-supplement-spotlight-vol-4-pqq/


Sayiner, S., Sehirli, A. O., Serakinci, N. (2021). Alpha lipoic acid as a potential treatment for COVID-19 - a hypothesis. Retrieved October 26, 2021 from https://pesquisa.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-1050862


Johnson, C. (2021). Mitochondrial Enhancers for ME/CFS and Fibromyalgia Part III: Magnesium. Retrieved October 26, 2021 from https://www.healthrising.org/blog/2021/08/06/mitochondria-chronic-fatigue-syndrome-fibromyalgia-magnesium/


Harris, C. B. et al. (2013). Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects. Retrieved October 26, 2021 from https://pubmed.ncbi.nlm.nih.gov/24231099/

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