What is Toxoplasmosis gondii?
DISCLAIMER: CONSULT WITH A DOCTOR BEFORE DECIDING ON A TREATMENT PLAN FOR ANY DISEASE OR INJURY.
Toxoplasma gondii is a protozoan parasite that causes a disease known as toxoplasmosis. It is found throughout the world, but cats are a common host for the disease. Actually, though cats are a host for toxoplasmosis, many people catch the disease from food and water exposures.
In the scientific research, Toxoplasmosis protozoa have demonstrated the ability to manipulate the behavior of its hosts to create a more favorable situation for its own reproduction. The severity of the behavioral changes correspond to the number of Toxoplasmosis cysts. The number of Toxoplasma cysts indirectly indicate the level of brain inflammation in the host.
Scientists have speculated that Toxoplasmosis protozoa are able to manipulate host behavior by altering the immune system, but in animal studies, rats develop more exploratory behavior when they’re infected with Toxoplasmosis. Exploratory behavior is associated with dopamine levels in the brain, which are probably altered by the Toxoplasmosis protozoa as well. Nonetheless, scientists have shown that neurons can be remodeled by this parasite to cause hypomethylation of arginine vasopressin-related genes (arginine vasopressin is also known as Anti-Diuretic Hormone or Argipressin). Methylation issues can lead to various diseases including autism. Interestingly, organophosphate exposure and the resultant vitamin K2 deficiency can also cause methylation issues.
Arginine Vasopressin / Anti-Diuretic Hormone plays some important roles in the body. It increases how much water is reabsorbed back into the blood supply by the kidneys. And it also causes the arteries to constrict in order to increase peripheral vascular resistance, raising blood pressure levels. Vascular resistance can cause problems like high blood pressure, of course, but it also plays a role in diverting blood toward the digestive system to ensure that food is properly digested and absorbed. So the role of Arginine Vasopressin on vascular resistance is important in that this substance alters which organs are supplied with more or less blood. Studies have also shown that Arginine Vasopressin is released into the brain where it plays a role in social behavior, bonding in couples, sexual motivation / libido, as well as how mothers respond to stress. And finally, Arginine Vasopressin also induces differentiation of heart muscle cells to help promote a healthy heart.
In those with a Toxoplasmosis gondii infection, Arginine Vasopressin is altered in the brain, which means that people with this disease can develop changes in the following:
- Social behavior
- Relationship behavior
- Sexual motivation and libido
- Maternal stress responses and behaviors.
What Is Toxo Positive? Toxoplasmosis Exposure and Resistance
In humans, exposure to toxoplasmosis is frequent with exposure rates ranging between 30 to 35%. But while both exposure and infection to the disease is common, most of those who are actually infected with the disease don’t have symptoms because the immune system prevents the protozoa from actually causing illness.
This fact is vital to an understanding of how to cure this disease. One of the most important strategies that can help patients is to work hard to restore the immune system to health. Using Lugol’s iodine, vitamin B17, and enzyme therapies as supplements that can help the body’s immune system become strong again is a good place to start.
Those with a chronic infection that isn’t accompanied by symptoms are said to have latent Toxoplasmosis. Those who have recurrent symptoms of Toxoplasmosis are said to have chronic Toxoplasmosis. While the popular notion has been that Toxoplasmosis is rare in the United States and Europe, this conflicts with scientific research that says that Toxoplasmosis infection is a global threat that, according to some seroprevalence studies, affects up to 100% of the population of the world. Indeed, seroprevalence in the United States specifically has been shown to include at least 25% of individuals. In Europe, the rate of infection ranges between 10-60% and in some regions it may be as high as 90%.
Scientific studies indicate that eating habits and health practices impact whether or not Toxoplasmosis infection takes hold and actually causes disease in a given individual, but our view is that immune system function is really the major player here. If the immune system is suppressed or not functioning properly due to toxic exposure to things like bromide / bromine or organophosphates, which are nearly ubiquitous in the United States and certain other developed countries in the world, people become vulnerable to this disease.
Toxoplasmosis and Autoimmune Infection
Those with weakened immunity may experience the full-blown version of a Toxoplasmosis infection which can be fatal. So it’s important to work to raise and modulate immune system function in individuals who develop this disease. Co-infection with HIV / AIDs can lead to serious, life-threatening illness. Anyone with a weakened immune system and/or a Toxoplasmosis infection should read this article by Dr. Metharem Haresh about how he cures HIV / AIDs using a substance known as Tetrasilver Tetroxide.
Also worth noting is the fact that autoimmunity and cancer are, according to the latest scientific research, two sides of the same coin. Most autoimmune diseases involve a specific cancer corollary. And most cancers are also associated with autoimmune disease. This cancer-autoimmunity connection is described using the word “paraneoplastic” and we expand in depth on how and why Lugol’s iodine 2% can be used to treat both. Indeed, exposure to bromide-containing insecticides or organophosphates may be an important factor in determining who expresses symptoms of Toxoplasmosis and who does not. Read more here about paraneoplastic diseases and why Lugol’s iodine can be used to cure autoimmune diseases and cancer.
Toxoplasmosis and Mental Illness
The Toxoplasmosis protozoa contains two enzymes that directly affect the production of dopamine and serotonin in the brain, two neurotransmitters that can cause different types of mental illness if they become imbalanced. In the scientific literature, Toxoplasmosis has some interesting associations with the following mental illnesses:
- Bipolar Disorder
- Learning Disabilities
- Attention Deficit Hyperactivity Disorder (ADHD)
- Obsessive Compulsive Disorder (OCD)
- Anti-social Personality Disorder
- Panic Disorder
- Suicidal Behavior
The long list of psychiatric problems that are caused by a Toxoplasmosis infection brings to mind 3 things:
- Lithium Orotate –
Lithium Orotate is a natural salt that is non-toxic (as opposed to Lithium Carbonate, the toxic, synthetic pharmaceutical used to treat bipolar disorder). Lithium orotate is often found in the water supply and in areas of the world where it is naturally found at higher levels, people experience fewer psychological problems.
- Organophosphate Toxicity –
Organophosphate poisoning can cause problems like autism or ADHD via its effects on the shikimate pathway, vitamin K2 levels, and iodine levels in the body. Read more about how organophosphate insecticides cause psychiatric illness here.
- Bromism / Bromine Toxicity –
Bromism and bromine toxicity was once a well-known cause of up to 10% of all psychiatric hospital admissions. Bromism or bromine toxicity occurs when someone is exposed to bromine via the air, water, food, or pharmaceuticals that contain bromine. Though bromine has been outlawed in most countries, it has not been outlawed by the U.S. government and is, in fact, present in a variety of medications, foods, and in insecticides that are present in the air and in the water. Read more about the problem of bromine exposure here.
It’s common for patients who have immune system disorders to be more prone to experiencing mental illness or mood disorders due to the Toxoplasmosis parasite living in the brain. Patients with HIV / AIDs as well as patients with autoimmune disease are more likely to develop neurological issues related to Toxoplasmosis.
Given the facts regarding the prevalence of Toxoplasmosis infection, one might wonder whether the problem is truly a Toxoplasmosis infection or if the problem should be reframed into a problem of toxicity and/or low immunity due to toxins in the environment.
It’s significant to note that scientists have seen a number of instances where patients, for example, are diagnosed with a major mental disorder like schizophrenia or bipolar disorder when in fact, the patient has a treatable Toxoplamosis gondiii infection. So Toxoplasmosis and schizophrenia might, at least in some cases, be the same disease. The same is true for Toxoplamosis and bipolar disorder. And because lithium orotate can have such miraculous effects on most mental disorders, especially bipolar disorder, daily supplementation with lithium orotate is worth considering. As an alkalizing agent that can be used to do high pH therapy as a treatment for major diseases like cancer, lithium orotate may be able to reduce symptoms of Toxoplasmosis naturally while simultaneously giving the immune system a boost to cure Toxoplasma gondii. Read more about lithium orotate as a cure for neurological disease here.
We’ve also written about misdiagnosis of other types of parasite infection as they relate to ADHD as well as epilepsy. Specifically, children and adults with ADHD may have a pinworm infection, but studies have also shown that Toxoplasmsa infection can cause ADHD symptoms. Indeed, while doctors in Asian countries are mostly aware of the fact that epilepsy is misdiagnosed about 30% of the time and about ⅓ of patients who are diagnosed with epilepsy may spontaneously recover if the tapeworm cysts in the brain that are causing the disease suddenly die and leave the body, doctors in the U.S. still resist the idea that tapeworm cysts could cause a disease like epilepsy. New research, however, has shown that Toxoplasmosis is another common cause of seizures that can easily be misdiagnosed as epilepsy.
In terms of mental illness, patients who have received a grim diagnosis should consider the high rates of misdiagnosis when deciding on an action plan for treatment. Below are some of the cures for Toxoplasmosis that can be used by patients at home to see if they experience a lessening of mental health issues.
- Quinine / Cinchona officinalis Bark (herbal cure for Toxoplasmosis)
- Andrographis paniculata (herbal cure for Toxoplasmosis)
- Terminalia chebula (herbal cure for Toxoplasmosis)
- Chlorine Dioxide Solution / Miracle Mineral Supplement
Some experts believe that Toxoplasmosis infection can trigger the development of mental illness while other experts believe that Toxoplasmosis may be responsible for psychotic symptoms and other symptoms of mental illness. In other words, in some patients, symptoms of schizophrenia or other types of mental illness may be directly caused by a Toxoplasmosis infection. In other patients, Toxoplasmosis may trigger the development of mental illness even though it isn’t directly responsible for the symptoms. Again, it seems that Toxoplasmosis may be an infection that’s present in everyone’s body, but it may only affect those with weak immune systems or a high toxic load.
Toxoplasmosis is a common cause of uveitis and one of the most common causes of infectious posterior uveitis in people who are in normal, average health. The other common cause of uveitis in immunocompromised patients with HIV / AIDs is cytomegalovirus.
The symptoms associated with ocular toxoplasmosis vary depending on the patient’s age, their location in the world, and the size and severity of retinochoroiditis. Symptoms of ocular toxoplasmosis include:
- Blurry vision
- Decreased visual acuity (indicating macular involvement)
- Vitreous inflammation of the eye
- Retinal blood vessel inflammation
- Active lesions in the eye
- Retinochoroidal Necrosis
- Optic neuritis
As with neurological manifestations of Toxoplasmosis, recurrent retinochoroiditis adjacent to a scar can be confused or misdiagnosed as serpiginous choroiditis. Necrotizing retinitis due to any of the following can also be misdiagnosed as Toxoplasmic Necrotizing retinitis:
- White Dot Syndromes
- Herpes Zoster Virus
- Herpes Simplex Virus
- Septic Retinitis
- Fungal Retinitis (caused by Candida or blastomycosis)
- Ocular Toxocariasis
If you wish to cure ocular toxoplasmosis, look into Chlorine Dioxide Solution / Miracle Mineral Solution. To cure ocular toxoplasmosis, you’ll want to follow both a systemic protocol like Protocol 1000 as well as the Eye Protocol to cure the disease.
Other Important Links:
Flegr, J., Horacek, J. (2019). Negative Effects of Latent Toxoplasmosis on Mental Health. Retrieved July 18, 2022 from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040223/
Ngoungou, E. B. et al. (2015). Toxoplasmosis and epilepsy – systematic review and meta analysis. Retrieved July 18, 2022 from https://pubmed.ncbi.nlm.nih.gov/25695802/
Palmer, B. S. (2007). Meta-analysis of three case controlled studies and an ecological study into the link between cryptogenic epilepsy and chronic toxoplasmosis infection. Retrieved July 18, 2022 from https://pubmed.ncbi.nlm.nih.gov/17604653/
Galvan-Ramirez, M. L. et al. (2013). Seroepidemiology of Toxoplasma gondii infection in drivers involved in road traffic accidents in the metropolitan area of Guadalajara, Jalisco, Mexico. Retrieved July 18, 2022 from https://pubmed.ncbi.nlm.nih.gov/24499659/
Henriquez, S. A. et al. (2009). Neuropsychiatric disease and Toxoplasma gondii infection. Retrieved July 18, 2022 from https://pubmed.ncbi.nlm.nih.gov/19212132/
Oladapo, I. P. (2020). Toxoplasmosis: A Link To Mental Illness. Retrieved July 18, 2020 from file:///Users/jennifershipp/Downloads/Toxoplasmosis_A_Link_To_Mental_Illness.pdf
Soheilian, M. et al. (2011). How to Diagnose and Treat Ocular Toxoplasmosis. Retrieved July 18, 2022 from https://www.reviewofophthalmology.com/article/how-to-diagnose-treat-ocular-toxoplasmosis
Wikipedia (2022). Toxoplasmosis gondii. Retrieved July 15, 2022 from https://en.wikipedia.org/wiki/Toxoplasma_gondii
Dass, H., Vyas, A. (2014). Toxoplasma gondii infection reduces predator aversion in rats through epigenetic modulation in the host medial amygdala. Retrieved July 15, 2022 from https://pubmed.ncbi.nlm.nih.gov/25142402/
Flegr, J., Markos, A. (2014). Masterpiece of epigenetic engineering – how Toxoplasma gondii reprogrammes host brains to change fear to sexual attraction. Retrieved July 15, 2022 from https://pubmed.ncbi.nlm.nih.gov/25532868/
Flegr, J. et al. (2014). Toxoplasmosis – a global threat. Correlation of latent toxoplasmosis with specific disease burden in a set of 88 countries. Retrieved July 15, 2022 from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963851/
Jones, J. L. et al. (2001). Toxoplasma gondii infection in the United States: seroprevalence and risk factors. Retrieved July 15, 2022 from https://pubmed.ncbi.nlm.nih.gov/11495859/
Zohre, F. K. et al. (2019). Vitamin D Deficiency and Toxoplasma Infection. Retrieved July 15, 2022 from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635350/
Nolan, S. J. et al. (2018). Novel Approaches to Kill Toxoplasma gondii by Exploiting the Uncontrolled Uptake of Unsaturated Fatty Acids and Vulnerability to Lipid Storage Inhibition of the Parasite. Retrieved July 15, 2022 from https://pubmed.ncbi.nlm.nih.gov/30061287/
Pernas, L. et al. (2018). Mitochondria Restrict Growth of the Intracellular Parasite Toxoplasma gondii by Limiting Its Uptake of Fatty Acids. Retrieved July 15, 2022 from https://pubmed.ncbi.nlm.nih.gov/29617646/
Okhuarobo, A. et al. (2014). Harnessing the medicinal properties of Andrographis paniculata for diseases and beyond: a review of its phytochemistry and pharmacology. Retrieved July 15, 2022 from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032030/
Massimine, K. M. et al. (2005). Toxoplasma gondii is capable of exogenous folate transport. A likely expansion of the BT1 family of transmembrane proteins. Retrieved July 15, 2022 from https://pubmed.ncbi.nlm.nih.gov/16159678/
Knockel, J. et al. (2007). The apicomplexan parasite Toxoplasma gondii generates pyridoxal phosphate de novo. Retrieved July 15, 2022 from https://www.sciencedirect.com/science/article/pii/S0166685106003550?via%3Dihub
Zhang, Y. et al. (2020). Association between vitamin D deficiency and Toxoplasma gondii infection in women of childbearing age. Retrieved July 15, 2022 from https://pubmed.ncbi.nlm.nih.gov/32693884/
Zafar, R. et al. (2021). Toxoplasmosis in immunocompetent Saudi women: Correlation with vitamin D. Retrieved July 15, 2022 from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451252/
Fond, G. et al. (2013). Toxoplasma gondii: a potential role in the genesis of psychiatric disorders. Retrieved July 15, 2022 from https://pubmed.ncbi.nlm.nih.gov/23095600/
Learn, J. (2020). Lithium Treatments used for bipolar disorder shown to help fish fight parasite. Retrieved November 18, 2022 from https://abcnews.go.com/Technology/lithium-treatments-bipolar-disorder-shown-fish-fight-parasite/story?id=74197469
Wikipedia (2022). Bromism. Retrieved November 18, 2022 from https://en.wikipedia.org/wiki/Bromism