How Lithium Orotate Can Cure Nervous System Autoimmunity


Studies have shown that in areas of the world where there is a slightly higher amount of natural lithium salts in the water supply, there are lower levels of suicide, homocide, violence, depression, and mental health issues in general. Low levels of lithium are found in seawater supplements as well as in Himalayan sea salt and shilajit, but some individuals with mood disorders might choose to take a microdose of Lithium orotate at 5 mg to ensure that they get the proper amount each day. Lithium orotate may be increased safely to a dose of 20mg per day in most people, or even to a dose of up to 80-100mg under supervision. Lithium, like cesium therapy, is alkalizing, so higher doses should ideally be monitored by a professional. Autoimmune disease can be an emotional journey, and many patients suffer from mental health problems as a result of the stress that their disease puts on them. Lithium orotate can help balance these emotional issues in autoimmune patients. 


Besides being an important mood regulating nootropic medicine, lithium orotate can also be used to protect and heal damage done to the central nervous system. Autoimmune diseases like the following have been shown to benefit from lithium orotate supplementation: 

In the treatment of irritable bowel syndrome (which is an umbrella term that also encompasses ulcerative colitis and Crohn’s disease), lithium orotate has been shown to be able to inhibit the GSK3𝛃 enzyme. This enzyme is the primary one responsible for gastrointestinal inflammation in disorders like IBD, so lithium’s ability to inhibit GSK3𝛃 can help prevent inflammatory damage to the gastrointestinal tract in individuals with autoimmune gastrointestinal disorders

Patients with Hashimoto’s thyroiditis should be aware that studies are contradictory as to whether or not nutritional lithium like lithium orotate will help or harm the thyroid. Pharmaceutical lithium carbonate tends to have a negative effect on thyroid health, especially in patients with Hashimoto’s, but lithium present in the drinking water and/or lithium orotate administered at a dose between 5-20mg per day doesn’t appear to cause thyroid health problems. Nevertheless, some doctors recommend that Hashimoto’s patients who supplement with lithium orotate also take a zinc+copper supplement at a dose of 30-60mg of zinc to 2mg of copper per day. Zinc is especially important for the production of thyroid releasing hormone (TRH), and has been noted as being a particularly valuable supplement for Hashimoto’s patients. The copper helps ensure that long-term zinc supplementation doesn’t deplete copper levels. 



Lithium orotate may be especially beneficial for patients with autoimmune diseases that directly affect the nervous system, as well as for preventing inflammation caused by autoimmune reactions. Lithium can simultaneously help increase anti-inflammatory proteins in the body while also suppressing cytokine production and arachidonic acid, both of which are pro-inflammatory and can cause a specific kind of inflammation that can be damaging to organs and tissues. In autoimmune patients, both arachidonic acid and cytokines are implicated in many autoimmune inflammatory responses. 

Some studies have demonstrated that lithium orotate may have a role in reducing nervous system autoimmunity, and that it may be valuable in preventing neuroinflammation in particular. In the brain, lithium orotate increases levels of serotonin, dopamine, and glutamine, as well as encouraging neuronal growth and survival. It also has special neuroprotective effects and has been shown to inhibit the growth of plaques and tangles in dementia and Alzheimer’s patients.

In one animal study, lithium was found to reduce the symptoms of autoimmune encephalomyelitis. Specifically, demyelination, microglia activation, and leukocyte infiltration of the spinal cord were reduced. The researchers noted that lithium administration was able to reduce the overall severity of the disease, as well as even cause a partial recovery in the animals. These same principles seen in this study may apply to autoimmune encephalomyelitis and multiple sclerosis in humans. 


Lithium orotate supplementation may also benefit patients with systemic lupus erythematosus (SLE). One in vitro study demonstrated that decreased levels of interleukin-2 were correlated with more severe manifestations of SLE. However, administration of lithium was able to increase interleukin-2 production, which may indicate that lithium supplementation can reduce the severity of SLE in some cases. 

Patients with Felty’s Syndrome, a condition that can affect individuals with rheumatoid arthritis, benefit from lithium supplementation as well. Administration of lithium can enhance peripheral blood neutrophil levels in individuals with Felty’s Syndrome, and can reverse some symptoms of this condition, even sometimes to the point of complete reversal. 

Autoimmune patients who choose to take supplemental lithium should also consider incorporating zinc (with copper), vitamin E, and omega-3s and omega-6s into their supplementation protocol to see maximum benefits. Below are some other tell-tale signs of lithium deficiency that can help you determine if lithium orotate might be right for you: 

  • Anger/rage
  • Irritability
  • Depression/anxiety
  • Addiction
  • Eating disorders
  • Bipolar disorder
  • Cognitive decline
  • Alzheimer’s disease and/or dementia
  • Trouble concentrating
  • Memory loss


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Lithium Orotate: Not Just an Alternative Treatment for Depression, Bipolar, and Anxiety

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