Cryptolepis sanguinolenta is an important herbal cure for Lyme disease.

Scientifically Proven Lyme Disease Treatments

DISCLAIMER: Always consult a doctor before undergoing treatment of any kind. 

Below are some of the most powerful herbal remedies that can be used to treat Lyme disease. Some of these herbs are combined into one treatment in the following product, but in some cases, patients may have better success using the herbal Lyme disease cures listed below as separate treatments.

1. Cryptolepis sanguinolenta as an Herbal Cure for Lyme Disease

Cryptolepsis sanguinolenta has strong activity against Borrelia burgdorferi including non-growing, stationary phase B. burgdorferi. It has also been used as an herbal remedy for Babesia, a co-infection that commonly occurs with Lyme disease. Babesia is also often a co-infecting agent in malaria infection.


Cryptolepsis sanguinolenta is a better alternative treatment for Lyme disease than Andrographis paniculata. Some studies have shown that Cryptolepsis sanguinolenta was significantly more effective against the Lyme disease bacteria Borrelia burgdorferi than Andrographis paniculata despite earlier studies indicating that Andrographis paniculata would work as an herbal treatment for Lyme disease. It is possible that Andrographis paniculata would work in certain patients while Cryptolepsis sanguinolenta would work better in others. The difference between how these two plants affect Lyme disease patients may pertain to whether or not the herb is able to simultaneously treat Lyme co-infections. At any rate, Lyme disease patients who are not successful with Andrographis paniculata should consider the use of Cryptolepis sanguinolenta as yet another alternative. 


Cryptolepsis sanguinolenta is an African plant that has been used to treat the following diseases as well as Lyme disease:


  • Malaria
  • Tuberculosis
  • Hepatitis
  • Septicemia


It has the following medicinal effects on the body:


  • Anti-inflammatory
  • Anti-bacterial
  • Anti-fungal
  • Anti-amoebic
  • Anti-malarial


Cryptolepsis sanguinolenta is well-tolerated and generally does not produce side effects. It has been in use for hundreds of years in both India and China. Extract doses of 500 mg per kg of body weight are considered generally safe. 

2. Juglans nigra / Black walnut Herbal Remedy for Lyme

Juglans nigra, also known as Black Walnut, is second on this list of herbal remedies for Lyme disease. This herb has the following medicinal effects on the body:


  • Antibacterial
  • Anti-tumor
  • Chemoprotective
  • Antioxidant


Julgans nigra has scientifically documented activity against log phase spirochetes of Borrelia burgdorferi as well as Borrelia garinii round bodies as well as against biofilm formation.  


Juglans nigra generally produces few side effects. It is well-tolerated though some individuals experience gastrointestinal issues though it can cause skin pigmentation changes. Individuals who are allergic to walnuts and tree nuts may experience allergy against Juglans nigra. Cases of allergic dermatitis have also been reported.

Buy Juglans nigra here. 

3. Artemisia annua / Sweet wormwood

Artemisia annua is an herbal cure for Lyme disease as well as schistosomiasis and even cancer. It works by releasing Reactive Oxygen Species. It is most powerful when the body is exposed to sunlight after taking it. 


Artemisia annua is also known as Sweet Wormwood, Chinese Wormwood, or Qing Hao. It has been in use medicinally for over 2,000 years. One of the active ingredients in Artemisia annua, Artemisinin was recognized in 2015 as an important substance in the treatment of malaria, but it also has scientifically documented activity against stationary phase Borrelia burgdorferi.  


Studies have shown that artemisinin, a medicinal substance in Artemisia annua can reduce short-term memory impairment due to Lyme disease. The Reactive Oxygen Species released by Artemisia annua are able to damage proteins in the Borrelia burgdorferi bacteria. In scientific studies, both 60% and 90% alcohol extracts of Artemisia annua worked better as a treatment for Lyme disease than either cefuroxime or doxycycline.


In humans, Artemisia annua has been administered in doses up to 2,250 mg per day for up to 10 weeks. Up to 1800 mg per day can be administered safely for up to 6 months. 


At higher doses, digestive upsets can occur with nausea, vomiting, and abdominal pain.

Buy Artemisia annua here.

4. Hu Zhang / Polygonum cuspidatum as an Herbal Treatment for Lyme Disease

Polygonum cuspidatum has the following medicinal effects on the body:


  • Anti-inflammatory
  • Anti-microbial
  • Neuroprotective
  • Cardioprotective


Resveratrol is an important medicinal substance in Polygonum cuspidatum. Resveratrol has documented effects against log phase Borrelia burgdorferi and Borrelia garinii spirochetes, but it doesn’t display medicinal activity against Borrelia round bodies or biofilms. 


Emodin is another medicinal substance in Polygonum cuspidatum. Emodin has scientifically documented medicinal action against stationary phase Borrelia burgdorferi bacteria as well as anti-biofilm effects. 


Some people who take Polygonum cuspidatum experience gastrointestinal upsets with diarrhea that goes away if the dose is decreased or when treatment with this herb is discontinued.

Buy Polygonum cuspidatum here. 

5. Cistus incanus / Cistus creticus



Cistus incanus and Cistus creticus may actually be the same herb. Cistus incanus has been successfully used to treat inflammation and upper respiratory infection. And a volatile oil extract of Cistus creticus has been scientifically shown to be able to kill Borrelia burgdorferi bacteria. Additionally Cistus creticus has also shown anti-biofilm activity against Streptococcus mutans, as well as a reduced bacterial adherence to tooth enamel. 


Cistus creticus contains carvacrol, a substance that has significant activity against both log and stationary phase Borrelia burgdorferi.  


Cistus creticus and Cistus incanus plant extracts produce no side effects or allergic reactions. The dosage is 220 mg per day. 


6. Huang Qin / Scutellaria baicalensis / Chinese skullcap


Scutellaria baicalensis has the following medicinal effects on the body:


  • Neuroprotective
  • Anti-apoptotic
  • Antioxidant
  • Anti-inflammatory
  • Anti-excitatory
  • Sedative


The medicinally active constituent known as baicalein has activity against log phase spirochetes, latent round bodies, and biofilm of Borrelia burgdorferi and Borrelia garinii


Scutellaria baicalensis has sedative effects through its interaction with GABA receptors. 


This herbal remedy for Lyme disease can be toxic to the liver at the wrong dose. Scientists have identified a dose of 1335 mg daily as a safe dose that could be taken for up to 444 days with no adverse effects. 

Buy Scutellaria baicalensis here. 

7. Uncaria tomentosa / Cat’s claw Herbal Remedy for Lyme Disease

Uncaria tomentosa comes highly recommended as an herbal treatment for Lyme disease. The inner bark of the Cat’s Claw herb has been scientifically proven as an immunomodulator or an herb that has the ability to balance the effects of the immune system. It is a bitter herb that helps promote digestion. 


Take Cat’s Claw / Uncaria tomentosa with food. In order for it to work properly, you need stomach acid to activate it. 


Cat’s Claw is not recommended for pregnant or nursing women with Lyme disease.


Uncaria tomentosa has minimal side effects and a good safety profile though some patients reported nausea, diarrhea, anemia, and abdominal pain while taking this herb. The median dose is 16 mg per kilogram of body weight.  

Buy Uncaria tomentosa here.

8. Althea officinalis / Marshmallow Root as an Herbal Treatment for Lyme Disease

Marshmallow Root is an herb that works primarily with the respiratory system, digestive system, skin, and heart. It heals the inner lining of intestinal tissues to get rid of leaky gut syndrome. In those with Lyme disease, it also reduces inflammation and pain. 

9. Achillea millefolium / Yarrow as an Herbal Cure for Lyme Disease

Yarrow is an herb that purifies the blood, boosts immunity, lowers inflammation, and increases blood circulation. It has antimicrobial action in the body so it can help kill the Borrelia burgdorferi pathogen. This herb also balances reproductive system function, but it shouldn’t be used by women who are pregnant. 

Buy Achillea millefolium here.


Cure Lyme Disease: Scientifically Proven Treatments for Lyme Disease & Co-Infections – BUY NOW!


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Resources: (2020). Seven herbal medicines can kill Lyme disease bacteria in test tube. Retrieved July 19, 2022 from 


Hopeful Holistic (n.d.) 10 Extraordinary Herbs for Lyme Disease. Retrieved July 19, 2022 from 


Feng, J. et al. (2020). Evaluation of Natural and Botanical Medicines for Activity Against Growing and Non-growing Forms of B. burgdorferi. Retrieved July 19, 2022 from 


Feng, J. et al. (2020). Evaluation of Natural and Botanical Medicines for Activity Against Growing and Non-Growing Forms of B. burgdorferi. Retrieved July 19, 2022 from


Aspire (2022). Lyme Disease and Herbal Treatments – Dr. Wells. Herbal Treatments for Lyme Disease and Tick-Borne Infections. Retrieved July 19, 2022 from