Transverse Myelitis, Acute Disseminated Encephalomyelitis, and Other Post-Vaccine Demyelination Diseases

Transverse myelitis is a disorder that occurs when both sides of an area of the spinal cord become inflamed. The inflammation in transverse myelitis often leads to destruction of the myelin sheaths on the nerve cell, or even nerve cell death. This can cause symptoms such as chronic pain, muscle weakness, sensory problems, urinary retention or incontinence, bowel dysfunction, or even paralysis. Infection or other concurrent immune system disorders are generally considered to be the primary causes of transverse myelitis (COVID-19 is among the viral and bacterial diseases that can cause the onset of transverse myelitis, so it can be reasoned that the COVID-19 vaccine or vaccines for other causal diseases may also play a role in this disease’s development in some cases).


Vitamin B12 deficiency has been strongly connected to neuropathy and myelopathy, with some cases of transverse myelitis being correlated with an accompanying deficiency in this vitamin. One case study observed a man with vitamin B12 deficiency and secondary transverse myelitis (meaning that the transverse myelitis developed after and as a result of the nutritional deficiency). This man had been experiencing symptoms for over a year at the time that he received treatment, so researchers speculate that he would have recovered more fully and more quickly had he started vitamin B12 therapy sooner. Even still, the researchers noted that for people with secondary transverse myelitis, intravenous/injection-based vitamin B12 therapy can help begin to treat the disease within 3-6 months (full recovery may take longer than this, but changes become evident within this time). 


Notably, one study observed that one woman who developed acute transverse myelitis following vaccination with the Moderna COVID-19 vaccine also had a comorbidity of vitamin B12 deficiency. Though this particular study stated that the exact connection between the vaccine and the deficiency is uncertain, this is still notable and worth consideration for people who develop transverse myelitis following vaccination. A different study also notes that deficiencies in vitamin B12, vitamin D, vitamin E, and copper may play a role in the development of acute transverse myelitis in children. 


Acute disseminated encephalomyelitis (ADEM) generally develops within 7-21 days after a vaccination. The initial symptoms may include headache, vomiting, fever, and drowsiness, which usually progress to include confusion and disorientation, stupor, paralysis, incontinence or urinary retention, coma, and seizures. In some particularly severe cases, ADEM can result in death. Encephalomyelitis occurs primarily in the brain, but due to its similarity with transverse myelitis, the orthomolecular treatment for ADEM may be similar.


Other demyelination disorders or health problems resulting from demyelination that may benefit from a similar orthomolecular treatment as described above include: 


  • Neuromyelitis optica (Devic’s disease)
  • Chronic inflammatory demyelinating neuropathy
  • Impaired muscular coordination
  • Loss of sensation (sight, touch, smell, etc.)
  • Paresthesia
  • Ataxia (loss of voluntary movement)
  • Clumsiness
  • Speech and hearing problems
  • Progressive inflammatory neuropathy
  • Charcot-Marie-Tooth disease
  • Myelopathies
  • And more…


COVID-19 and Respiratory Infection Self treatment and Prevention BUNDLE – Volumes 1, 2, and 3

The Post-COVID Vaccine Recovery Book and Autoimmunity Reference Guide


Related Posts:

Vitamin B Deficiency Treatment: How to Dose B-Complex Vitamins for Healing

Multiple Sclerosis and Vitamin B Deficiency: The Connection Between Nutrition and MS

Post HPV Vaccine Syndrome, Autism, and Post COVID Vaccine Syndrome: Cures Derived from Similarities and Differences

Vitamin B1 Deficiency Symptoms: The Connection Between Dry Beriberi and Guillain-Barré Syndrome

Vitamin B Deficiency: Health Problems, Disorders, and Syndromes Caused by Vitamin B Deficiency

Autism and Vitamin B Deficiency: Orthomolecular Therapy for Autism Spectrum Disorders

The Role of Vitamins and Minerals in the Treatment of COVID and Long-Haul COVID



[1] Lanska, Douglas J. (2018). Neurologic complications of vaccination. Retrieved February 2, 2022 from:  https://www.medlink.com/articles/neurologic-complications-of-vaccination 

[2] Mayo Clinic (2022). Transverse myelitis. Retrieved February 2, 2022 from: https://www.mayoclinic.org/diseases-conditions/transverse-myelitis/symptoms-causes/syc-20354726


[3] Rocha Vasconcellos, Luiz Felipe, et. al. (2002). Mielopatía por deficiencia de vitamina B12 apresentando-se como mielite transversa. Retrieved February 2, 2022 from: https://www.hsph.harvard.edu/nutritionsource/vitamin-b12/  


[4] Gao, Jhih-Jian, et. al. (2021). Acute Transverse Myelitis Following COVID-19 Vaccination. Retrieved February 2, 2022 from: https://www.mdpi.com/2076-393X/9/9/1008/htm