Eggs, free-range/grass-fed meats, and goat’s milk are all healthy sources of thiamine and riboflavin. Dark leafy green vegetables, nuts, and legumes are also good choices.

Vitamins B1 and B2, thiamine and riboflavin, both play important roles in the treatment of multiple sclerosis. Some people have in the past speculated that MS may be caused by an overgrowth of Candida in the gastrointestinal tract, which is in fact one of the risk factors for the development of a deficiency in these vitamins since Candida overgrowth can interfere with gastrointestinal absorption of nutrients. Thus, orthomolecular treatment of MS should ideally be administered in combination with an anti-candida, healing diet rich in fresh produce and other whole ingredients. If Candida overgrowth is a part of the problem and isn’t corrected, it’s likely that supplementation with vitamins won’t have as significant of an impact, and also that the results of the treatment won’t last. 


With that said, both vitamin B2 and vitamin B1 deficiencies play a role in the development of multiple sclerosis. 


High dose thiamine (vitamin B1) therapy has been shown to be particularly useful in relieving some MS symptoms, such as severe fatigue. One study showed that both oral and intravenous administration of vitamin B1 improved fatigue symptoms in a group of 15 MS patients. The same study noted that the patients had normal blood thiamine and thiamine pyrophosphate levels, though symptoms improved with thiamine therapy. This suggests that MS patients may have problems with intracellular transport of nutrients or with the enzymes required to use thiamine in the body. 


Vitamin B2 (riboflavin) also plays an important role in the development and treatment of multiple sclerosis. Since riboflavin is a vital nutrient necessary for myelin formation, it stands to reason that the demyelination present in multiple sclerosis could be at least partially due to a deficiency in this vitamin. Strong correlations have been noted between riboflavin deficiency and the development of MS. Treatment of MS using riboflavin supplementation has also (logically) been shown to have positive results. 

A deficiency in riboflavin has also been linked to protein and DNA damage, and may alter the expression of various genes. These genetic changes may play a part in autoimmune disorders like multiple sclerosis, as well as in other similar autoimmune diseases like transverse myelitis, encephalomyelitis, Guillain-Barre Syndrome, and others. Additionally, riboflavin deficiency can interfere with electron transport, eventually leading to early cell death since cells aren’t able to receive enough energy.


Supplementation with riboflavin (either orally or intravenously) in addition to a healthy, balanced diet can correct problems associated with riboflavin deficiency, like multiple sclerosis. Including other B vitamins, like thiamine, can help improve the overall results of this treatment. 


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[1] Mount Sinai (n.d). Vitamin B1 (Thiamine). Retrieved February 2, 2022 from: https://www.mountsinai.org/health-library/supplement/vitamin-b1-thiamine 


[2] Mount Sinai (n.d). Vitamin B2 (Riboflavin). Retrieved February 2, 2022 from: https://www.mountsinai.org/health-library/supplement/vitamin-b2-riboflavin 


[3] Constantini, Antonio, et. al. (2013). High dose thiamine improves fatigue in multiple sclerosis. Retrieved February 8, 2022 from: https://casereports.bmj.com/content/2013/bcr-2013-009144.short 


[4] Naghashpour, Mahshid, et. al. (2017). Update on riboflavin and multiple sclerosis: a systematic review. Retrieved February 8, 2022 from: ​​https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651462/