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Vitamins B1 and B2, thiamine and riboflavin, both play important roles in the treatment of multiple sclerosis. Some people have in the past speculated that MS may be caused by an overgrowth of Candida in the gastrointestinal tract, which is in fact one of the risk factors for the development of a deficiency in these vitamins since Candida overgrowth can interfere with gastrointestinal absorption of nutrients. Thus, orthomolecular treatment of MS should ideally be administered in combination with an anti-candida, healing diet rich in fresh produce and other whole ingredients. If Candida overgrowth is a part of the problem and isn’t corrected, it’s likely that supplementation with vitamins won’t have as significant of an impact, and also that the results of the treatment won’t last.
With that said, both vitamin B2 and vitamin B1 deficiencies play a role in the development of multiple sclerosis.
High dose thiamine (vitamin B1) therapy has been shown to be particularly useful in relieving some MS symptoms, such as severe fatigue. One study showed that both oral and intravenous administration of vitamin B1 improved fatigue symptoms in a group of 15 MS patients. The same study noted that the patients had normal blood thiamine and thiamine pyrophosphate levels, though symptoms improved with thiamine therapy. This suggests that MS patients may have problems with intracellular transport of nutrients or with the enzymes required to use thiamine in the body.
Vitamin B1 should be administered at a dose of 1000-2000mg per day for the treatment of multiple sclerosis. Fred R. Klenner, MD used this dose successfully to improve the symptoms of his MS patients.
Vitamin B2 (riboflavin) also plays an important role in the development and treatment of multiple sclerosis. Since riboflavin is a vital nutrient necessary for myelin formation, it stands to reason that the demyelination present in multiple sclerosis could be at least partially due to a deficiency in this vitamin. Strong correlations have been noted between riboflavin deficiency and the development of MS. Treatment of MS using riboflavin supplementation has also (logically) been shown to have positive results.
A deficiency in riboflavin has also been linked to protein and DNA damage, and may alter the expression of various genes. These genetic changes may play a part in autoimmune disorders like multiple sclerosis, as well as in other similar autoimmune diseases like transverse myelitis, encephalomyelitis, Guillain-Barre Syndrome, and others. Additionally, riboflavin deficiency can interfere with electron transport, eventually leading to early cell death since cells aren’t able to receive enough energy.
Vitamin B2 should be administered at a dose of 10mg/kg of body weight per day. Therefore, if a person weighs 70kg (about 155 pounds), they should be taking 700mg of vitamin B2/riboflavin per day. People who weight less will take less, and people who weigh more will take more.
Supplementation with riboflavin (either orally or intravenously) in addition to a healthy, balanced diet can correct problems associated with riboflavin deficiency, like multiple sclerosis. Including other B vitamins, like thiamine, can help improve the overall results of this treatment. Include a B-100 supplement along with high dose riboflavin and thiamine treatment to ensure that your body is getting adequate levels of all of the B-complex vitamins. The B-complex vitamins are (in most cases) dependent on each other to function properly, so it’s important to make sure that you’re also getting sufficient amounts of the other B vitamins, too, to increase the chances of success with this multiple sclerosis treatment.
Vitamin B12 is another B vitamin often implicated in the development or worsening of multiple sclerosis and other similar symptoms. People who are vegan or strict vegetarians, as well as some people on certain medications, are significantly more likely to develop a deficiency in this vitamin. Read more about vitamin B12 deficiency at this link. People who are unable to obtain intramuscular injections of vitamin B12 or IV treatment with this vitamin should consider combining it with DMSO to enhance its absorption. For the treatment of multiple sclerosis, maximum absorption of these nutrients is key, and since vitamin B12 isn’t particularly well absorbed when taken orally, combining with DMSO as described in this article is a good option if you’re unable to get injections or IV therapy.
Finally, vitamin B3, otherwise known as niacin, is a must-take supplement for multiple sclerosis patients. Dr. Abram Hoffer has successfully used niacin on over 60 MS patients to reduce symptoms significantly. When the treatment was begun early in the disease progression, the results tended to be more profound. Dr. Hoffer administered his MS patients an oral dose of 3000-6000mg of vitamin B3 per day in divided doses. The same doctor has had success using niacin (especially in combination with other vitamin and mineral supplements) to treat not only multiple sclerosis, but also other serious illnesses such as schizophrenia, Alzheimer’s, migraines, Parkinson’s disease, and more. The book Niacin: The Real Story offers a more detailed look at how niacin can be used to treat different illnesses like these.
 Mount Sinai (n.d). Vitamin B1 (Thiamine). Retrieved February 2, 2022 from: https://www.mountsinai.org/health-library/supplement/vitamin-b1-thiamine
 Mount Sinai (n.d). Vitamin B2 (Riboflavin). Retrieved February 2, 2022 from: https://www.mountsinai.org/health-library/supplement/vitamin-b2-riboflavin
 Constantini, Antonio, et. al. (2013). High dose thiamine improves fatigue in multiple sclerosis. Retrieved February 8, 2022 from: https://casereports.bmj.com/content/2013/bcr-2013-009144.short
 Naghashpour, Mahshid, et. al. (2017). Update on riboflavin and multiple sclerosis: a systematic review. Retrieved February 8, 2022 from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651462/
 Kmiec, Mitchelle (n.d.) Thiamine: An Important Vitamin for Multiple Sclerosis. Retrieved May 27, 2022 from: https://www.onlineholistichealth.com/multiple-sclerosis-and-thiamine/