DISCLAIMER: CONSULT WITH A DOCTOR BEFORE DECIDING ON A TREATMENT PLAN FOR ANY DISEASE OR INJURY.
In one study on female rats with PCOS and induced hyperandrogegism, royal jelly was administered to the test group for 4 weeks during treatment. The royal jelly was administered at a dose of 200mg/kg each day during this time. The results of the study concluded that the rats who had been given royal jelly had improved reproductive hormone levels (including more normal, balanced levels of testosterone, estradiol, follicle-stimulating hormone, and luteinizing hormone. In addition, the rats taking royal jelly also had more regular estrus cycles and improved ovarian health.
Notably, royal jelly has been shown to improve estrus response and rates of pregnancy among ewes as well as rats. These effects are caused by royal jelly’s ability to improve ovarian follicle growth and development and increase the secretion of estradiol, a luteinizing hormone that encourages ovulation. It also has estrogenic activity in the body. Royal jelly may also mimic the action of gonadotropins, which are hormones secreted by the pituitary gland that work directly with gonads, or reproductive organs, in both men and women. This suggests that royal jelly may be able to function similarly to eCG (equine chorionic gonadotropin), a substance used to increase fertility in some animals prior to artificial insemination.
Other studies using royal jelly for the treatment of PCOS and/or infertility have included:
- Administration of 250mg/kg of royal jelly to female sheep over the course of 12 days of estrus synchronization. This study observed that the royal jelly behaved similar to gonadotropin hormones and that the female sheep were more likely to conceive with only one mating encounter.
- Intraperitoneal injection of 100mg/kg, 200mg/kg, and 400mg/kg of royal jelly in rats. Progesterone and estradiol production was stimulated and mature follicles and corpora lutea were increased. Uterine and ovarian weight was also higher. These results occurred regardless of the amount of royal jelly administered (both the lower and higher amounts were effective).
Based on these dosages, a human woman would have to take between 5,000mg to 30,000mg of royal jelly per day to obtain the same results (a woman weighing 110 pounds taking 100mg/kg would take 5000, whereas a woman weighing 165 pounds taking 400mg/kg would take 30,000; adjust the dosages according to your weight and how much royal jelly you’re planning to take daily).
 Ab Hamid, Norhamidar, et. al. (2020). Composition of Royal Jelly (RJ) and its Anti-Androgenic Effect on Reproductive Parameters in a Polycystic Ovarian Syndrome (PCOS) Animal Model. Retrieved December 31, 2021 from:
 Hashen, Nesrein M. et. al. (2021). Improving Reproductive Performance and Health of Mammals Using Honeybee Products. Retrieved December 31, 2021 from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996195/