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What is Kambo?
Kambo is also known as “frog medicine” or sapo (Phyllomedusa bicolor). The medicine is the venomous secretion of the Giant Leaf Frog (also known as the Monkey Frog). This frog is found in the rainforest regions of Brazil, Peru, Columbia, Venezuela, the Guianas, and Bolivia. To obtain the venom from the toad, hunters locate the frog by following their distinctive song. When the find the giant monkey frogs, they kill them, but rather, they tie them up by the legs and the stress of this situation causes them to excrete the secretion. The venom is placed on small pieces of wood and stored for up to a year without losing potency.
Kambo is an “ordeal medicine” that causes powerful emetic or purgative effects, which can be unpleasant, but many people report that after the initial unpleasantness, their health is improved. It is known as the “vaccine of the forest” and it’s immune-boosting properties have been shown to be effective at treating diseases and disorders that are otherwise incurable.
Kambo is administered by mixing it with saliva or water and applying it directly to small burns made in the skin. It has a number of therapeutic applications including increased physical strength, heightened senses and alertness as well as elevated mood. People who take kambo often report a decrease in stress and better focus. The following diseases and disorders may respond to treatment with kambo:
- Alzheimer’s and Parkinson’s Disease
- Deep Detoxification
- Vascular insufficiency and blood circulation problems
- Candida (tryptophyllins, in particular have been shown to inhibit the growth of Candida albicans as well as Staphylococcus aureus and Escherichia coli.)
- Organ diseases
- Fertility issues
- Chronic pain
- Addiction to opiates or prescription painkillers.
- Lyme Disease
- Panema (negative energies).
Kambo Peptides and How They Impact Health
Tachykinnins: These neuropeptides modulate dopamine, serotonin, and other neurotransmitter levels. These are the neurotransmitters that have the biggest impact on many addictive behaviors.
Bradykinnins: The bradykinnins increase the blood-brain permeability.
Caeruleins: The caeruleins have an impact on the pituitary and adrenal glands and they also give the nervous system a chance to reboot.
Sauvagine: Sauvagines have opiate-like activity in the brain. They have pain-killing properties more potent than morphine or endogenous beta-endorphine. The effect of sauvagines on the pituitary-adrenal axis and the coricotropin-releasing receptors are vital in terms of impacting issues related to cortisol levels, stress, anxiety, depression, and addiction.
Deltorphin: These are some of the most powerful pain-killing chemicals currently known to man. Deltorphins bind to delta opioid receptors.
Dermaseptin: Dermaseptins have antimicrobial properties that work against bacteria, yeasts, fungi, and viruses (including HSV-1 and HIV-1).
Dermatoxins: Dermatoxins are antimicrobial like dermaseptins except that they are also bactericidal against mollicutes, Gram-positive eubacteria and to a lesser extent, Gram-negative eubacteria.
Tryptophyllin: These neuropeptides are particularly relevant to neurological health. They have antimicrobial properties.
Calcitonins: The calcitonins dilate the blood vessels to help prevent the development of high blood pressure and other cardiovascular pathologies that are caused by hypertension. Calcitonins also impact skin and joint health and have shown potential for use in treating diabetes and obesity.
Neuropeptide Y: Skin Peptide Tyrosine-Tyrosine (SPYY) is a peptide that can protect the body from bacteria, fungi, and protozoa. It may also have an impact on circadian rhythm, histamine release, autonomic and endocrine function, sympathetic vascular control, and food intake.
Kambo for Cancer
Kambo contains peptides that are able to cross the blood-brain barrier and it also has antibiotic properties that can boost the immune system while simultaneously killing pathogens. It is well-known as an anti-inflammatory. And Kambo is also famous for working on the spiritual level of disease, so it can have an impact on cancer at many levels. Though kambo treatment should be done as a stand-alone treatment and should not be mixed with other medicinals, cancer patients could benefit from adding other alternative therapies into their treatment protocol.
One study showed that tryptophyllins found in the Kambo venom had an anti-proliferative effect on human prostate cancer cells lines. And it was able to slow the growth of cancer cells without any undesirable side effects.
At the University of Paris and Queens University in Belfast, researchers found that dermaseptin peptides can kill certain types of cancer cells. Dermaseptin was able to inhibit the growth of tumors, kill cancer cells, but also not cause damage or toxicity to mammalian cells in the process.
Kambo for Infertility
As an alternative infertility treatment, Kambo reduces inflammation and strengthens the immune system. It also works on a psycho-spiritual level to detoxify both the mind and body which can be extremely beneficial for those who are struggling with fertility issues. Those who are struggling with fertility issues may also benefit from adding iodine therapy and amino acid therapies to their regime after their kambo ritual.
Kambo for Cataracts
Studies have shown that Kambo is able to improve eyesight perhaps due to its anti-inflammatory properties.
Kambo for Depression
Researchers have shown that depression and chronic inflammation are related issues. When a patient has chronic inflammation, he or she is much more likely to be depressed. And depressed patients often have chronic inflammation in the body. Kambo is an anti-inflammatory so it isn’t surprising that it could have an impact on depression. But beyond its anti-inflammatory properties, the Kambo venom is a cocktail of chemicals that Big Pharma has used to synthesize over 70 potentially powerful medicinal derivatives that are currently patented, primarily in the U.S. Dermaseptins, in particular, have been identified for their impact on depression via adrenoregulin receptors.
Read more below about the effects of kambo on the brain and neurological functioning to better understand how it can impact depression.
Kambo for Addictions
Research has shown that kambo is able to cross the blood-brain barrier to stimulate the endocrine glands of the brain and disrupt the addiction process. Since amino acid therapy is one of the least well-known addiction treatments, but also one that appears to have a strong impact on reducing withdrawal symptoms, it isn’t surprising that Kambo’s ability to disrupt the addictive process is attributed to its peptide content. Peptides, after all, are made up of amino acids. Having the proper amount and types of amino acids help addicts boost the production of the proper neurotransmitters after years of abusing drugs. Kambo can disrupt the addictive process while feeding the brain peptides like tachykinnins that increase dopamine (pleasure) and serotonin (happiness) levels. Sauvagines and deltorphins have opiate-like activity in the brain with pain-killing properties more potent than morphine, but less addictive when presented in the context of the kambo cocktail.
Kambo for Alzheimer’s or Parkinson’s Disease
The dermaseptin peptides in Kambo hold a lot of promise as a targeted treatment for Alzheimer’s and Parkinson’s Disease.
Kambo for Psoriasis
Though kambo has not been studied scientifically to determine its exact effects on psoriasis, some psoriasis sufferers have reported that the disease went into remission after they did a kambo ceremony. One of the reasons why kambo may be beneficial for psoriasis sufferers is because it is said to cleanse and detoxify the body. Indigenous tribes in the Amazon would use kambo when tribe members were unsuccessful at a hunt or to expel sickness from the body.
On the other hand, some kambo practitioners say that using kambo to treat psoriasis is contra-indicated. Indeed, these practitioners say that autoimmune disorders should not be treated using kambo so psoriasis sufferers may wish to do a spot test on the skin prior to having the kambo administered via a burn, or skip the treatment altogether. Again, some psoriasis sufferers have experienced remission from their disease, but because there is no scientific research on the effects of kambo on psoriasis, patients must decide for themselves if this treatment seems right to them.
What is the Kambo experience like?
Kambo produces immediate effects that usually last between 10 to 40 minutes. Effects include:
- Rise in temperature
- Rise in heart-rate
- Blood pressure changes (including an awareness of the veins and arteries)
- Tingling or burning sensation that spreads through the body
- Dissociative states
- Drunken high
- Nausea and vomiting
- Feeling of pressure in the head, neck, or torso
- Stomach pain
- Inflammation of the throat
- Blurry vision (or temporary blindness)
- Difficulty moving
- Numb or swollen lips and tongue
Most people fast for 8 to 10 hours prior to taking kambo. It is advisable to avoid salt as well as all solid foods for at least 8 to 10 hour prior to the ceremony. Alcohol should also be avoided for 24 to 48 hours prior to taking Kambo. It is best to find someone who is knowledgeable about administering kambo rather than trying to self-administer it. Self-administration can be dangerous and a sitter is always necessary.
Other Important Links:
 University of Healing (2016). Kambo to help with psoriasis. Retrieved March 24, 2020 from http://kambo.me/smf/index.php?topic=557.0
 Reddit (n.d.) Kambo or No Kambo on an Ayahuasca Journey? Retrieved March 25, 2020 from https://www.reddit.com/r/Kambo/comments/8b7398/kambo_or_no_kambo_on_an_ayahuasca_journey/
 The Third Wave (2019). The Ultimate Guide to Kambo. Retrieved March 25, 2020 from https://thethirdwave.co/psychedelics/kambo/
 MundoKambo (2019). Testimonio de Kambo psoriasis severa en Casa y Escuela Medicine Pahcalli Phatekatl. Retrieved March 25, 2020 from https://www.facebook.com/watch/?v=1310645362406782
 Keppel, J. M. (2018). Kambo and its Multitude of Biological Effects: Adverse Events or Pharmacological Effects? Retrieved March 25, 2020 from https://www.researchgate.net/publication/330624667_Kambo_and_its_Multitude_of_Biological_Effects_Adverse_Events_or_Pharmacological_Effects
 Psychedelic Times (n.d.). Kambo. Retrieved March 25, 2020 from https://psychedelictimes.com/kambo/
 KamboPath.Net (n.d.) What does science know about Kambo? Retrieved March 25, 2020 from https://www.kambopath.net/science
 Medicine Frog Kambo. (n.d.). Frequently Asked Questions. Retrieved March 25, 2020 from https://medicinefrogkambo.com/faq/