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The sleep disorders associated with various types of dementia may respond well to treatment with melatonin. One study examined the value of melatonin supplements in Alzheimer’s patients who suffered from “sundowner’s syndrome” where the chronobiological rhythm of the sleep-wake cycle has been disturbed. Melatonin supplements offset these disturbances and other sleep-wake disorders in Alzheimer’s patients .
Researchers have noted that in Alzheimer’s disease, melatonin secretion diminishes which causes circadian rhythm disorganization, decreased sleep efficiency, and impaired cognitive dysfunction. Both animal and human studies have shown that low melatonin levels are correlated with delirium, dementia, mild cognitive impairment, and behavioral problems. Some scientists believe that melatonin replacement can slow the onset of dementia because of its neuro-protective mechanisms. Recently, clinical trials have shown that both melatonin and its analogs can have an important impact on the prevention, treatment, and management of delirium and dementia .
Dr. Boeve recommends graduating the dose of melatonin from 3 mg to 12 mg over time.
Other Important Links:
 Lewy Body Dementia Association (2018). Treatment. Retrieved January 7, 2019 from https://www.lbda.org/go/treatment-0
 Cardinali, D. P., Furio, A. M., Brusco, L. I. (2010). Clinical Aspects of Melatonin Intervention in Alzheimer’s Disease Progression. Retrieved January 9, 2019 from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001215/
 Alagiakrishnan, K. (2016). Melatonin Based Therapies for Delirium and Dementia. Retrieved January 9, 2019 from http://www.discoverymedicine.com/Kannayiram-Alagiakrishnan-2/2016/05/melatonin-based-therapies-for-delirium-and-dementia/
 McGrane, I. R., Leung, J. G., St. Louis, E. K., Boeve, B. F. (2015). Melatonin Therapy for REM Sleep Behavior Disorder: A Critical Review of the Evidence. Retrieved January 9, 2019 from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306603/